969 research outputs found
On the non-abelian Brumer-Stark conjecture and the equivariant Iwasawa main conjecture
We show that for an odd prime p, the p-primary parts of refinements of the
(imprimitive) non-abelian Brumer and Brumer-Stark conjectures are implied by
the equivariant Iwasawa main conjecture (EIMC) for totally real fields.
Crucially, this result does not depend on the vanishing of the relevant Iwasawa
mu-invariant. In combination with the authors' previous work on the EIMC, this
leads to unconditional proofs of the non-abelian Brumer and Brumer-Stark
conjectures in many new cases.Comment: 33 pages; to appear in Mathematische Zeitschrift; v3 many minor
updates including new title; v2 some cohomological arguments simplified; v1
is a revised version of the second half of arXiv:1408.4934v
An opinion paper: emphasis on white muscle development and growth to improve farmed fish flesh quality
Due to rapid depletion of wild stocks, the necessity to cultivate fish is eminent. Current fish farming practices seek to improve flesh quality. The notion that white muscles are the main target of the fishing industry is emphasized. A novel approach is suggested based on the development of white muscles in wild fish from eggs to adults. A compilation of facts about white muscle structure, function and ontogeny is followed by an account of the changes in swimming behaviour and performance related to the use of white muscle during growth from larva to adult. Ecological data narrate early swimming performance with white muscle development and growth, unveiling some of the important natural selection factors eliminating weak swimmers and poor growers from the breeding stock. A comparison between fish culture practise and natural conditions reveals fundamental differences. New approaches following wild breeding processes promise several important advantages regarding the quality of white muscle
Early Clinical and Subclinical Visual Evoked Potential and Humphrey's Visual Field Defects in Cryptococcal Meningitis.
Cryptococcal induced visual loss is a devastating complication in survivors of cryptococcal meningitis (CM). Early detection is paramount in prevention and treatment. Subclinical optic nerve dysfunction in CM has not hitherto been investigated by electrophysiological means. We undertook a prospective study on 90 HIV sero-positive patients with culture confirmed CM. Seventy-four patients underwent visual evoked potential (VEP) testing and 47 patients underwent Humphrey's visual field (HVF) testing. Decreased best corrected visual acuity (BCVA) was detected in 46.5% of patients. VEP was abnormal in 51/74 (68.9%) right eyes and 50/74 (67.6%) left eyes. VEP P100 latency was the main abnormality with mean latency values of 118.9 (±16.5) ms and 119.8 (±15.7) ms for the right and left eyes respectively, mildly prolonged when compared to our laboratory references of 104 (±10) ms (p<0.001). Subclinical VEP abnormality was detected in 56.5% of normal eyes and constituted mostly latency abnormality. VEP amplitude was also significantly reduced in this cohort but minimally so in the visually unimpaired. HVF was abnormal in 36/47 (76.6%) right eyes and 32/45 (71.1%) left eyes. The predominant field defect was peripheral constriction with an enlarged blind spot suggesting the greater impact by raised intracranial pressure over that of optic neuritis. Whether this was due to papilloedema or a compartment syndrome is open to further investigation. Subclinical HVF abnormalities were minimal and therefore a poor screening test for early optic nerve dysfunction. However, early optic nerve dysfunction can be detected by testing of VEP P100 latency, which may precede the onset of visual loss in CM
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Shading Beats Binocular Disparity in Depth from Luminance Gradients: Evidence against a Maximum Likelihood Principle for Cue Combination
Perceived depth is conveyed by multiple cues, including binocular disparity and luminance shading. Depth perception from luminance shading information depends on the perceptual assumption for the incident light, which has been shown to default to a diffuse illumination assumption. We focus on the case of sinusoidally corrugated surfaces to ask how shading and disparity cues combine defined by the joint luminance gradients and intrinsic disparity modulation that would occur in viewing the physical corrugation of a uniform surface under diffuse illumination. Such surfaces were simulated with a sinusoidal luminance modulation (0.26 or 1.8 cy/deg, contrast 20%-80%) modulated either in-phase or in opposite phase with a sinusoidal disparity of the same corrugation frequency, with disparity amplitudes ranging from 0’-20’. The observers’ task was to adjust the binocular disparity of a comparison random-dot stereogram surface to match the perceived depth of the joint luminance/disparitymodulated corrugation target. Regardless of target spatial frequency, the perceived target depth increased with the luminance contrast and depended on luminance phase but was largely unaffected by the luminance disparity modulation. These results validate the idea that human observers can use the diffuse illumination assumption to perceive depth from luminance gradients alone without making an assumption of light direction. For depth judgments with combined cues, the observers gave much greater weighting to the luminance shading than to the disparity modulation of the targets. The results were not well-fit by a Bayesian cue-combination model weighted in proportion to the variance of the measurements for each cue in isolation. Instead, they suggest that the visual system uses disjunctive mechanisms to process these two types of information rather than combining them according to their likelihood ratios
Two chemically similar stellar overdensities on opposite sides of the plane of the Galaxy
Our Galaxy is thought to have undergone an active evolutionary history
dominated by star formation, the accretion of cold gas, and, in particular,
mergers up to 10 gigayear ago. The stellar halo reveals rich fossil evidence of
these interactions in the form of stellar streams, substructures, and
chemically distinct stellar components. The impact of dwarf galaxy mergers on
the content and morphology of the Galactic disk is still being explored. Recent
studies have identified kinematically distinct stellar substructures and moving
groups, which may have extragalactic origin. However, there is mounting
evidence that stellar overdensities at the outer disk/halo interface could have
been caused by the interaction of a dwarf galaxy with the disk. Here we report
detailed spectroscopic analysis of 14 stars drawn from two stellar
overdensities, each lying about 5 kiloparsecs above and below the Galactic
plane - locations suggestive of association with the stellar halo. However, we
find that the chemical compositions of these stars are almost identical, both
within and between these groups, and closely match the abundance patterns of
the Milky Way disk stars. This study hence provides compelling evidence that
these stars originate from the disk and the overdensities they are part of were
created by tidal interactions of the disk with passing or merging dwarf
galaxies.Comment: accepted for publication in Natur
Thermodynamic curvature and black holes
I give a relatively broad survey of thermodynamic curvature , one spanning
results in fluids and solids, spin systems, and black hole thermodynamics.
results from the thermodynamic information metric giving thermodynamic
fluctuations. has a unique status in thermodynamics as being a geometric
invariant, the same for any given thermodynamic state. In fluid and solid
systems, the sign of indicates the character of microscopic interactions,
repulsive or attractive. gives the average size of organized mesoscopic
fluctuating structures. The broad generality of thermodynamic principles might
lead one to believe the same for black hole thermodynamics. This paper explores
this issue with a systematic tabulation of results in a number of cases.Comment: 27 pages, 10 figures, 7 tables, 78 references. Talk presented at the
conference Breaking of Supersymmetry and Ultraviolet Divergences in extended
Supergravity, in Frascati, Italy, March 27, 2013. v2 corrects some small
problem
3-D Ultrastructure of O. tauri: Electron Cryotomography of an Entire Eukaryotic Cell
The hallmark of eukaryotic cells is their segregation of key biological functions into discrete, membrane-bound organelles. Creating accurate models of their ultrastructural complexity has been difficult in part because of the limited resolution of light microscopy and the artifact-prone nature of conventional electron microscopy. Here we explored the potential of the emerging technology electron cryotomography to produce three-dimensional images of an entire eukaryotic cell in a near-native state. Ostreococcus tauri was chosen as the specimen because as a unicellular picoplankton with just one copy of each organelle, it is the smallest known eukaryote and was therefore likely to yield the highest resolution images. Whole cells were imaged at various stages of the cell cycle, yielding 3-D reconstructions of complete chloroplasts, mitochondria, endoplasmic reticula, Golgi bodies, peroxisomes, microtubules, and putative ribosome distributions in-situ. Surprisingly, the nucleus was seen to open long before mitosis, and while one microtubule (or two in some predivisional cells) was consistently present, no mitotic spindle was ever observed, prompting speculation that a single microtubule might be sufficient to segregate multiple chromosomes
The what and where of adding channel noise to the Hodgkin-Huxley equations
One of the most celebrated successes in computational biology is the
Hodgkin-Huxley framework for modeling electrically active cells. This
framework, expressed through a set of differential equations, synthesizes the
impact of ionic currents on a cell's voltage -- and the highly nonlinear impact
of that voltage back on the currents themselves -- into the rapid push and pull
of the action potential. Latter studies confirmed that these cellular dynamics
are orchestrated by individual ion channels, whose conformational changes
regulate the conductance of each ionic current. Thus, kinetic equations
familiar from physical chemistry are the natural setting for describing
conductances; for small-to-moderate numbers of channels, these will predict
fluctuations in conductances and stochasticity in the resulting action
potentials. At first glance, the kinetic equations provide a far more complex
(and higher-dimensional) description than the original Hodgkin-Huxley
equations. This has prompted more than a decade of efforts to capture channel
fluctuations with noise terms added to the Hodgkin-Huxley equations. Many of
these approaches, while intuitively appealing, produce quantitative errors when
compared to kinetic equations; others, as only very recently demonstrated, are
both accurate and relatively simple. We review what works, what doesn't, and
why, seeking to build a bridge to well-established results for the
deterministic Hodgkin-Huxley equations. As such, we hope that this review will
speed emerging studies of how channel noise modulates electrophysiological
dynamics and function. We supply user-friendly Matlab simulation code of these
stochastic versions of the Hodgkin-Huxley equations on the ModelDB website
(accession number 138950) and
http://www.amath.washington.edu/~etsb/tutorials.html.Comment: 14 pages, 3 figures, review articl
Empirical analysis shows reduced cost data collection may be an efficient method in economic clinical trials
Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
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