A Framework for Assessing the Rationality of Judgments in Carcinogenicity Hazard Identification

Arguing that guidelines for identifying carcinogens now lack a philosophically rigorous framework, the authors present an alternative that draws clear attention to the process of reasoning towards judgments of carcinogenicity

The lone parent pilots after 12 to 24 months: an impact assessment of in-work credit, work search premium, extended schools childcare, quarterly work focused interviews and new deal plus for lone parents

From April 2004, a set of Government policies designed to help lone parents into work have been piloted in various combinations in a number of Jobcentre Plus districts in Great Britain. The five policies are: In Work Credit (IWC), Work Search Premium (WSP), Extended Schools Childcare (ESC) and Childcare Tasters, Quarterly Work Focused Interviews (QWFIs) for lone parents whose youngest child is aged 12 or over in Local Education Authorities (LEAs) in which an ESC pilot is operating (ESQWFI), and New Deal Plus for Lone Parents (ND+fLP), hereafter collectively referred to as 'the lone parent pilots' (LPPs or 'the pilots'). The pilots were rolled out in four Phases, the first three of which are analysed in this report. This report estimates the impact of the LPPs on lone parents who have received Income Support (IS) or Jobseeker's Allowance (JSA) for at least 12 months. It uses a difference-in-differences (DiD) estimator, and makes use of lone parents in districts not operating a pilot as a comparison group. The data covers the first 12 months (Phase 3 districts) to the first 24 months (Phase 1 districts) of the pilots' operation, and so should be seen as giving the early impacts. Impacts were estimated separately for the stock of lone parents who had been on benefit for at least 12 months when the pilots began, and the flow sample of lone parents whose claim of IS/JSA reached 12 months after the pilots began

Climate Change: Some Scientific and Political Realities

Atmospheric scientists tell us that mankind is changing the climate, and is setting in motion forces that can make essentially irreversible changes in the climate of the future. Naysayers dispute whether mankind is even capable of changing the climate. Today we are hearing more from the scientists and less from the naysayers. This presentation will review highlights of the science and the political response to the scientific facts, at both the national and international levels. Domestically, the next chapter will be written by the incoming administration

Climate Change Awareness Time Line: How Did We Get to Today?

The climate change issue has really entered the awareness of the general public within the last two years or so. During that time, references in the media have progressed from the back page of the newspapers to front page news. Other than in the minds of atmospheric scientists, environmentalists, and policy makers, climate change had seemed to be a distant threat that could be dealt with at a later time, if needed. Within the last two years, the public awareness of the issue has become almost universal, penetrating the fiber of almost all mass communications media, from the comic strips to national TV programming

Crossover from weak localization to weak antilocalization in a disordered microbridge

We calculate the weak localization correction in the double crossover to broken time-reversal and spin-rotational symmetry for a disordered microbridge or a short disordered wire using a scattering-matrix approach. Whereas the correction has universal limiting values in the three basic symmetry classes, the functional form of the magnetoconductance is affected by eventual non-homogeneities in the microbridge.Comment: 5 pages, RevTeX; 2 figure

Ionized polycyclic aromatic hydrocarbons in space

The mid-infrared spectrum of a continuously increasing number of stellar objects, planetary and reflection nebulae, H-II regions and extragalactic sources show a distinctive set of broad emission features at 3.3, 3.4, 6.2, 7.7, 8.6, and 11.3 micron known collectively as the unidentified infrared emission bands. A model is summarized in which the bands arise from positively charged polycyclic hydrocarbons (PAH's) on the basis of their low ionization potential and the excellent agreement between the emission bands and laboratory spectra of auto exhaust which contains these types of molecules. The proposed presence of PAHs in such a variety of objects points to their presence in the interstellar medium. Out of a previously published collection of solid state PAH radical cation spectra five were selected on the basis of the unique thermodynamic stability of their carrier and compared directly to the wavelengths of the DIB's. Although the match seems quite favorable, strongly suggesting that PAH radicals are the long sought after carrier of the diffuse interstellar absorption bands, much laboratory work must be done to test this hypothesis

Sexual negotiation in the AIDS era: negotiated safety revisited

Objective: To test the safety of the 'negotiated safety' strategy - the strategy of dispensing with condoms within HIV-seronegative concordant regular sexual relationships under certain conditions. Method: Data from a recently recruited cohort of homosexually active men (Sydney Men and Sexual Health cohort, n = 1037) are used to revisit negotiated safety. The men were surveyed using a structured questionnaire and questions addressing their sexual relationships and practice, their own and their regular partner's serostatus, agreements entered into by the men concerning sexual practice within and outside their regular relationship, and contextual and demographic variables. Results: The findings indicate that a significant number of men used negotiated safety as an HIV prevention strategy. In the 6 months prior to interview, of the 181 men in seroconcordant HIV-negative regular relationships, 62% had engaged in unprotected anal intercourse within their relationship, and 91% (165 men) had not engaged in unprotected anal intercourse outside their relationship. Of these 165 men, 82% had negotiated agreements about sex outside their relationship. The safety of negotiation was dependent not only on seroconcordance but also on the presence of an agreement; 82% of the men who had not engaged in unprotected anal intercourse outside their regular relationship had entered into an agreement with their partner, whereas only 56% of those who had engaged in unprotected anal intercourse had an agreement. The safety of negotiation was also related to the nature of the safety agreement reached between the men and on the acceptability of condoms. Agreements between HIV-negative seroconcordant regular partners prohibiting anal intercourse with casual partners or any form of sex with a casual partner were typically complied with, and men who had such negotiated agreements were at low risk of HIV infection. Conclusions: The adoption of the strategy of negotiated safety among men in HIV-seronegative regular relationships may help such men sustain the safety of their sexual practice

Net energy analysis of solar and conventional domestic hot water systems in Melbourne, Australia

It is commonly assumed that solar hot water systems save energy and reduce greenhouse gas emissions. Very rarely has the life-cycle energy requirements of solar hot water systems been analysed, including their embodied energy. The extent to which solar hot water systems save energy compared to conventional systems in Melbourne, Australia, is shown through a comparative net energy analysis. The solar systems provided a net energy saving compared to the conventional systems after 0.5 to 2 years, for electricity and gas systems respectively.<br /

Assessment of upper tropospheric HOx sources over the tropical Pacific based on NASA GTE/PEM data: Net effect on HOx and other photochemical parameters

Data for the tropical upper troposphere (8-12 km, 20° N-20° S) collected during NASA's Pacific Exploratory Missions have been used to carry out a detailed examination of the photochemical processes controlling HOx (OH+HO2). Of particular significance is the availability of measurements of nonmethane hydrocarbons, oxygenated hydrocarbons (i.e., acetone, methanol, and ethanol) and peroxides (i.e., H2O2 and CH3OOH). These observations have provided constraints on model calculations permitting an assessment of the potential impact of these species on the levels of HOx, CH3O2, CH2O, as well as ozone budget parameters. Sensitivity calculations using a time-dependent photochemical box model show that when constrained by measured values of the above oxygenated species, model estimated HOx levels are elevated relative to unconstrained calculations. The impact of constraining these species was found to increase with altitude, reflecting the systematic roll-off in water vapor mixing ratios with altitude. At 11-12 km, overall increases in HOx approached a factor of 2 with somewhat larger increases being found for gross and net photochemical production of ozone. While significant, the impact on HOx due to peroxides appears to be less than previously estimated. In particular, observations of elevated H2O2 levels may be more influenced by local photochemistry than by convective transport. Issues related to the uncertainty in high-altitude water vapor levels and the possibility of other contributing sources of HOx are discussed. Finally, it is noted that the uncertainties in gas kinetic rate coefficients at the low temperatures of the upper troposphere and as well as OH sensor calibrations should be areas of continued investigation. Copyright 1999 by the American Geophysical Union

Formaldehyde over the central Pacific during PEM-Tropics B

Formaldehyde, CH2O, mixing ratios are reported for the central Pacific troposphere from a series of 41 flights, which took place in March-April 1999 as part of the NASA Pacific Exploratory Mission (PEM) -Tropics B mission. Ambient CH2O was collected in aqueous media and quantified using an enzyme-derivatization fluorescence technique. Primary calibration was performed using aqueous standards and known flow rates. Occasionally, CH2O gas standard additions to ambient air were performed as a secondary calibration. Analytical blanks were determined by replacing ambient air with pure air. The estimated precision was ±30 pptv and the estimated accuracy was the sum of ±30 parts per trillion by volume (pptv) ±15% of the measured value. Approximately 25% of the observations were less than the instrumental detection limit of 50 pptv, and 85% of these occurred above 6 km. CH2O mixing ratios decreased with altitude; for example, near the equator the median value in the lowest 2 km was 275 pptv, decreased to 150 pptv by 6 km and was below 100 pptv above 8 km. Between 130 and 170 W and below 1km, a small variation of CH2O mixing ratio with latitude was noted as near-surface median mixing ratios decreased near the equator (275 pptv) and were greater on either side (375 pptv). A marked decrease in near-surface CH2O (200 pptv) was noted south of 23° S on two flights. Between 3° and 23° S, median CH2O mixing ratios were lower in the eastern tropical Pacific than in the western or central Pacific; nominal differences were &gt;100 pptv near the surface to ∼100 pptv at midaltitude to ∼50 pptv at high altitude. Off the coast of Central America and Mexico, mixing ratios as high as 1200 pptv were observed in plumes that originated to the east over land. CH2O observations were consistently higher than the results from a point model constrained by other photochemical species and meteorological parameters. Regardless of latitude or longitude, agreement was best at altitudes above 4 km where the difference between measured and modeled CH2O medians was less than 50 pptv. Below 2 km the model median was approximately 150 pptv less than the measured median. Copyright 2001 by the American Geophysical Union