378 research outputs found
Supersymmetric Extension of GCA in 2d
We derive the infinite dimensional Supersymmetric Galilean Conformal Algebra
(SGCA) in the case of two spacetime dimensions by performing group contraction
on 2d superconformal algebra. We also obtain the representations of the
generators in terms of superspace coordinates. Here we find realisations of the
SGCA by considering scaling limits of certain 2d SCFTs which are non-unitary
and have their left and right central charges become large in magnitude and
opposite in sign. We focus on the Neveu-Schwarz sector of the parent SCFTs and
develop, in parallel to the GCA studies recently in (arXiv:0912.1090), the
representation theory based on SGCA primaries, Ward identities for their
correlation functions and their descendants which are null states.Comment: La TeX file, 32 pages; v2: typos corrected, journal versio
GCA in 2d
We make a detailed study of the infinite dimensional Galilean Conformal
Algebra (GCA) in the case of two spacetime dimensions. Classically, this
algebra is precisely obtained from a contraction of the generators of the
relativistic conformal symmetry in 2d. Here we find quantum mechanical
realisations of the (centrally extended) GCA by considering scaling limits of
certain 2d CFTs. These parent CFTs are non-unitary and have their left and
right central charges become large in magnitude and opposite in sign. We
therefore develop, in parallel to the usual machinery for 2d CFT, many of the
tools for the analysis of the quantum mechanical GCA. These include the
representation theory based on GCA primaries, Ward identities for their
correlation functions and a nonrelativistic Kac table. In particular, the null
vectors of the GCA lead to differential equations for the four point function.
The solution to these equations in the simplest case is explicitly obtained and
checked to be consistent with various requirements.Comment: 45 pages; v2: 47 pages. Restructured introduction, minor corrections,
added references. Journal versio
Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats
textabstractHere we show that Doxil® has minimal antitumour activity in the isolated limb perfusion (ILP) setting and its activity was not enhanced by the addition of tumour necrosis factor (TNF). Doxil® accumulation in tumour tissue was low and also not augmented by TNF. In contrast, activity of free conventional doxorubicin was enhanced by TNF. We conclude that application of Doxil® in a TNF-based ILP is not a useful alternative to free conventional doxorubicin or melphalan
Universal time-dependent deformations of Schrodinger geometry
We investigate universal time-dependent exact deformations of Schrodinger
geometry. We present 1) scale invariant but non-conformal deformation, 2)
non-conformal but scale invariant deformation, and 3) both scale and conformal
invariant deformation. All these solutions are universal in the sense that we
could embed them in any supergravity constructions of the Schrodinger invariant
geometry. We give a field theory interpretation of our time-dependent
solutions. In particular, we argue that any time-dependent chemical potential
can be treated exactly in our gravity dual approach.Comment: 24 pages, v2: references adde
Enhanced Supersymmetry of Nonrelativistic ABJM Theory
We study the supersymmetry enhancement of nonrelativistic limits of the ABJM
theory for Chern-Simons level . The special attention is paid to the
nonrelativistic limit (known as `PAAP' case) containing both particles and
antiparticles. Using supersymmetry transformations generated by the monopole
operators, we find additional 2 kinematical, 2 dynamical, and 2 conformal
supercharges for this case. Combining with the original 8 kinematical
supercharges, the total number of supercharges becomes maximal: 14
supercharges, like in the well-known PPPP limit. We obtain the corresponding
super Schr\"odinger algebra which appears to be isomorphic to the one of the
PPPP case. We also discuss the role of monopole operators in supersymmetry
enhancement and partial breaking of supersymmetry in nonrelativistic limit of
the ABJM theory.Comment: 22 pages, references added, version to appear in JHE
Charged, conformal non-relativistic hydrodynamics
We embed a holographic model of an U(1) charged fluid with Galilean
invariance in string theory and calculate its specific heat capacity and
Prandtl number. Such theories are generated by a R-symmetry twist along a null
direction of a N=1 superconformal theory. We study the hydrodynamic properties
of such systems employing ideas from the fluid-gravity correspondence.Comment: 31 pages, 1 figure, JHEP3 style, refs added, typos corrected, missing
terms in spatial charge current and field corrections added, to be published
in JHE
Conformal Quivers and Melting Molecules
Quiver quantum mechanics describes the low energy dynamics of a system of
wrapped D-branes. It captures several aspects of single and multicentered BPS
black hole geometries in four-dimensional supergravity such
as the presence of bound states and an exponential growth of microstates. The
Coulomb branch of an Abelian three node quiver is obtained by integrating out
the massive strings connecting the D-particles. It allows for a scaling regime
corresponding to a deep AdS throat on the gravity side. In this scaling
regime, the Coulomb branch is shown to be an invariant
multi-particle superconformal quantum mechanics. Finally, we integrate out the
strings at finite temperature---rather than in their ground state---and show
how the Coulomb branch `melts' into the Higgs branch at high enough
temperatures. For scaling solutions the melting occurs for arbitrarily small
temperatures, whereas bound states can be metastable and thus long lived.
Throughout the paper, we discuss how far the analogy between the quiver model
and the gravity picture, particularly within the AdS throat, can be taken.Comment: 49 pages, 16 figure
Fermions and the Sch/nrCFT Correspondence
We consider the problem of Dirac fermions propagating on a spacetime of
Schr\"odinger isometry and the associated boundary Euclidean two-point function
of fermionic scaling operators of the holographic dual non-relativistic
conformal theory. Paying careful attention to the representations of the
Schr\"odinger algebra that appear in this problem, we show carefully how the
on-shell action is constructed and how the boundary theory may be renormalized
consistently by the inclusion of appropriate Galilean invariant boundary
counterterms.Comment: 18 page
Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery
Tumour necrosis factor (TNF)-based isolated limb perfusion (ILP) is an approved and registered treatment for sarcomas confined to the limbs in Europe since 1998, with limb salvage indexes of 76%. TNF improves drug distribution in solid tumours and secondarily destroys the tumour-associated vasculature (TAV). Here we explore the synergistic antitumour effect of another vasoactive agent, histamine (Hi), in doxorubicin (DXR)-based ILP and evaluate its antivascular effects on TAV. We used our well-established rat ILP model for in vivo studies looking at tumour response, drug distribution and effects on tumour vessels. In vitro studies explored drug interactions at cellular level on tumour cells (BN-175) and Human umbilical vein endothelial cells (HUVEC). There was a 17% partial response and a 50% arrest in tumour growth when Hi was combined to DXR, without important side effects, against 100% progressive disease with DXR alone and 29% arrest in tumour growth for Hi alone. Histology documented an increased DXR leakage in tumour tissue combined to a destruction of the TAV, when Hi was added to the ILP. In vitro no synergy between the drugs was observed. In conclusion, Hi is a vasoactive drug, targeting primarily the TAV and synergises with different chemotherapeutic agents
Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT)
<p>Abstract</p> <p>Background</p> <p>The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS) in the general adult population.</p> <p>Methods</p> <p>In the Nord-Trøndelag Health Study (HUNT) the association between the Val158Met polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals. Two different cut off scores (≥ 8 and ≥ 11) were used to identify cases with anxiety (HADS-A) and depression (HADS-D), whereas controls had HADS-A <8 and HADS-D <8.</p> <p>Results</p> <p>The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of ≥ 8. When utilizing the alternative cut-off score HADS-D ≥ 11, Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: p = 0.017, allele: p = 0.006). In the multivariate analysis, adjusting for age and heart disease, depression (HADS-D ≥ 11) was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18–0.76).</p> <p>Conclusion</p> <p>In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely among men with depression defined as HADS-D ≥ 11, but this may be an incidental finding.</p
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