Acurácia no diagnóstico da alça anterior do nervo mentual através de radiografias panorâmicas digitais e tomografia computadorizada de feixe cônico

Orientador: José Ricardo de Albergaria BarbosaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de PiracicabaResumo: A reabilitação bucal com implantes dentários revolucionou a odontologia. No entanto, conhecimentos anatômicos como também técnicos são essenciais para a realização de um adequado tratamento. Desta forma, a reabilitação através da instalação de implantes dentários na região interforaminal (forames mentuais) tornou-se comum em reabilitações totais mandibulares. Em consequência disto, um grande número de transtornos sensoriais tem sido descritos e relacionados a alças anteriores do nervo mentual. A divisão do canal mandibular em nervo mentual, responsável pela inervação de tecidos moles (mucosa vestibular, fundo de sulco vestibular, mucosa labial do lábio inferior, pele do mento e lábio inferior), e feixe incisivo, que pode localizar-se no canal incisivo e é responsável pela inervação da região ântero-inferior (dentes e tecidos periodontais) deve ser considerada no planejamento de intervenções nesta região. A injúria a alça do nervo mentual do canal mandibular e ao feixe incisivo poderá trazer transtornos como perda de sensibilidade, edema, hematoma e falha na osseointegração. Apesar de ser considerada uma área segura para cirurgias ela é muito negligenciada no planejamento de tais procedimentos. A associação do conhecimento anatômico, tanto clínico quanto de imagens, torna o procedimento mais previsível devido às variações anatômicas, fazendo-se necessários exames de imagens, essenciais no controle de acidentes relacionados aos procedimentos de implantes intraforaminais. Como um dos exames de imagem mais utilizado em implantes dentais, a radiografia panorâmica apresenta precisão diagnóstica questionável. Portanto, verificamos a precisão da radiografia panorâmica quando comparada com a tomografia computadorizada cone-beam no diagnóstico da alça anterior do nervo mentual. Palavras chave: radiografia.panorâmica, tomografia computadorizada de feixe cônico, alça anterior do nervo mentual.Abstract: Oral rehabilitation with dental implants has revolutionized dentistry. However, both anatomical and technical knowledge are essential to provide an appropriate treatment. Thus, the rehabilitation by installing dental implants at interforaminal region (mental foramina) has become common in total mandibular rehabilitation. Consequently, a large number of sensory disorders has been described and related to the anterior loop of mental nerve. The division of the mandibular canal into mental nerve, responsible for innervation of soft tissues (buccal mucosa, bottom of buccal sulcus, labial mucosa of the lower lip, skin of the chin and lower lip), and incisive branch, which may be located in the incisive canal and is responsible for the innervation of the lower anterior region (teeth and periodontal tissues) should be considered during the planning of interventions in this region. Injury to the loop of the mental nerve of the mandibular canal and to the incisive branch will likely bring disorders such as loss of sensitivity, swelling, hematoma and failure of osseointegration. Although considered a safe area for surgery, it is very neglected in the planning of such procedures. The association of anatomical knowledge, both clinical and of images, makes the procedure more predictable due to anatomical variations, making the imaging examinations necessary, which are essential in the control of accidents related to intraforaminal implant procedures. As one of the most widely used imaging examinations in dental implants, panoramic radiograph presents questionable diagnostic accuracy. Therefore, we verified the accuracy of panoramic radiograph in comparison with cone-beam computed tomography in the diagnosis of the anterior loop of the mental nerve. Keywords: panoramic radiography, cone-beam computed tomography, anterior loop length, mental nerve.DoutoradoCirurgia e Traumatologia Buco-Maxilo-FaciaisDoutor em Clínica Odontológic

Efeito de brocas para implantes sobre o tecido osseo : estudo histologico em cães

Orientador: Luis Augusto PasseriDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de PiracicabaResumo: o sucesso do tratamento, através da colocação de implantes, exige leitos receptores adequados, para que ocorra uma osseointegração ideal. O equipamento utilizado para a confecção destas cavidades deve ser o mais preciso possível, devendo promover cortes com paredes bastante regulares e sem áreas de necrose. Com o objetivo de avaliar histologicamente, o efeito das brocas para implantes sobre o tecido ósseo utilizou-se sete cães, confeccionando-se, na mandibula de cada um deles, orifícios para colocação de implantes, seguindo a seqüência de brocas sugerida pelos fabricantes dos sistemas Nobel Biocare, ImpJamed e 3i. Após a confecção das cavidades, removeu-se o fragmento ósseo, e executou-se cortes semi-seriados de 6 f.lIll, no sentido don longo eixo dos cortes, e coloração com hematoxilina e eosina. A avaliação microscópica mostrou cortes regulares com poucas áreas de necrose e esquírolas ósseas, evidenciando que a técnica utilizada foi adequada, atestando a qualidade das brocasAbstract: The success of the treatment through the placement of osseointegrated implants will require appropriate cavities so it happen an ideal osseointegration. The equipment that was needed to make these cavities must be the most accurate promoting holes with uniform wall and without necrosls area. With intention to avaluate the histollogical effects of burs over the osseous tissue it was used eight dogs, made in the lower jaw holes to place the implants following the sequence of burs suggested by manufacturers After the holes were made the osseous fragments were removed and made semiseriate .incisions of 6 JlIIl following the long axis of the holes and stained with heinatoxiline and eosine A microscopic avaluation showed sharp incision, few necrosis area and bone fragments meaning that applied technique was adequated and proving the quality of the bursMestradoMestre em Odontologi

Surgical techniques for the treatment of ankyloglossia in children: a case series

This paper reports a series of clinical cases of ankyloglossia in children, which were approached by different techniques: frenotomy and frenectomy with the use of one hemostat, two hemostats, a groove director or laser. Information on the indications, contraindications, advantages and disadvantages of the techniques was also presented. Children diagnosed with ankyloglossia were subjected to different surgical procedures. The choice of the techniques was based on the age of the patient, length of the frenulum and availability of the instruments and equipment. All the techniques presented are successful for the treatment of ankyloglossia and require a skilled professional. Laser may be considered a simple and safe alternative for children while reducing the amount of local anesthetics needed, the bleeding and the chances of infection, swelling and discomfort

Effects of Exercise Training on Circulating and Skeletal Muscle Renin-Angiotensin System in Chronic Heart Failure Rats

Background: Accumulated evidence shows that the ACE-AngII-AT1 axis of the renin-angiotensin system (RAS) is markedly activated in chronic heart failure (CHF). Recent studies provide information that Angiotensin (Ang)-(1-7), a metabolite of AngII, counteracts the effects of AngII. However, this balance between AngII and Ang-(1-7) is still little understood in CHF. We investigated the effects of exercise training on circulating and skeletal muscle RAS in the ischemic model of CHF.Methods/Main Results: Male Wistar rats underwent left coronary artery ligation or a Sham operation. They were divided into four groups: 1) Sedentary Sham (Sham-S), 2) exercise-trained Sham (Sham-Ex), sedentary CHF (CHF-S), and exercise-trained CHF (CHF-Ex). Angiotensin concentrations and ACE and ACE2 activity in the circulation and skeletal muscle (soleus and plantaris) were quantified. Skeletal muscle ACE and ACE2 protein expression, and AT1, AT2, and Mas receptor gene expression were also evaluated. CHF reduced ACE2 serum activity. Exercise training restored ACE2 and reduced ACE activity in CHF. Exercise training reduced plasma AngII concentration in both Sham and CHF rats and increased the Ang-(1-7)/AngII ratio in CHF rats. CHF and exercise training did not change skeletal muscle ACE and ACE2 activity and protein expression. CHF increased AngII levels in both soleus and plantaris muscle, and exercise training normalized them. Exercise training increased Ang-(1-7) in the plantaris muscle of CHF rats. the AT1 receptor was only increased in the soleus muscle of CHF rats, and exercise training normalized it. Exercise training increased the expression of the Mas receptor in the soleus muscle of both exercise-trained groups, and normalized it in plantaris muscle.Conclusions: Exercise training causes a shift in RAS towards the Ang-(1-7)-Mas axis in skeletal muscle, which can be influenced by skeletal muscle metabolic characteristics. the changes in RAS circulation do not necessarily reflect the changes occurring in the RAS of skeletal muscle.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundacao ZerbiniCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ São Paulo, Sch Med, Heart Inst InCor HCFMUSP, São Paulo, BrazilUniv São Paulo, Sch Phys Educ & Sport, São Paulo, BrazilUniv São Paulo, Inst Biomed Sci, Dept Physiol & Biophys, São Paulo, BrazilUniversidade Federal de São Paulo, Kidney & Hypertens Hosp, Div Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Kidney & Hypertens Hosp, Div Nephrol, São Paulo, BrazilFAPESP: FAPESP-2010/50048-1Web of Scienc

Sugarcane (Saccharum X officinarum): A Reference Study for the Regulation of Genetically Modified Cultivars in Brazil

Global interest in sugarcane has increased significantly in recent years due to its economic impact on sustainable energy production. Sugarcane breeding and better agronomic practices have contributed to a huge increase in sugarcane yield in the last 30 years. Additional increases in sugarcane yield are expected to result from the use of biotechnology tools in the near future. Genetically modified (GM) sugarcane that incorporates genes to increase resistance to biotic and abiotic stresses could play a major role in achieving this goal. However, to bring GM sugarcane to the market, it is necessary to follow a regulatory process that will evaluate the environmental and health impacts of this crop. The regulatory review process is usually accomplished through a comparison of the biology and composition of the GM cultivar and a non-GM counterpart. This review intends to provide information on non-GM sugarcane biology, genetics, breeding, agronomic management, processing, products and byproducts, as well as the current technologies used to develop GM sugarcane, with the aim of assisting regulators in the decision-making process regarding the commercial release of GM sugarcane cultivars

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Precisión en el diagnóstico del bucle del nervio mental. estudio comparativo entre radiografía panorámica y tomografía computadorizada de haz cónico

Dental implant and chin osteotomy are executed on the mandible body and the mental nerve is an important anatomical limit. The aim of this research was to know the position of the mental nerve loop comparing result in panoramic radiography and cone beam computed tomography. We analyzed 94 hemimandibles and the patient sample comprised female and male subjects of ages ranging from 18 to 52 years (mean age, 35 years) selected randomly from the database of patients at the Division of Oral Radiology at Piracicaba Dental School State University of Campinas; the anterior loop (AL) of the mental nerve was evaluated regarding the presence or absence, which was classified as rectilinear or curvilinear and measurement of its length was obtained. The observations were made in the digital panoramic radiography (PR) and the cone beam computed tomography (CBCT) according to a routine technique. The frequencies of the AL identified through PR and CBCT were different: in PR the loop was identified in 42.6% of cases, and only 12.8% were bilateral. In contrast, the AL was detected in 29.8% of the samples using CBCT, with 6.4% being bilateral; Statistical comparison between PR and CBCT showed that the PR led to false-positive diagnosis of the AL in this sample. According to the results of this study, the frequency of AL is low. Thus, it can be assumed that it is not a common condition in this population.Dental implant and chin osteotomy are executed on the mandible body and the mental nerve is an important anatomical limit. The aim of this research was to know the position of the mental nerve loop comparing result in panoramic radiography and cone beam c331327332sem informaçãosem informaçãoImplantes dentales y la osteotomía de mentón son realizadas en el cuerpo mandibular y el nervio mental es un importante limite anatómico. El objetivo de esta investigación es conocer la posición del bucle del nervio mental comparando resultados entre rad