Validity of the activPAL3 activity monitor in people moderately affected by Multiple Sclerosis

Background: Walking is the primary form of physical activity performed by people with Multiple Sclerosis (MS), therefore it is important to ensure the validity of tools employed to measure walking activity. The aim of this study was to assess the criterion validity of the activPAL3 activity monitor during overground walking in people with MS.\ud Methods: Validity of the activPAL3 accelerometer was compared to video observation in 20 people moderately affected by MS. Participants walked 20-30m twice along a straight quiet corridor at a comfortable speed.\ud Results: Inter-rater reliability of video observations was excellent (all intraclass correlations > 0.99). The mean difference (activPAL3- mean of raters) was -4.70 ± 9.09, -4.55 s ± 10.76 and 1.11 s ± 1.11 for steps taken, walking duration and upright duration respectively. These differences represented 8.7, 10.0 and 1.8% of the mean for each measure respectively. The activPAL3 tended to underestimate steps taken and walking duration in those who walked at cadences of ≤ 38 steps/minute by 60% and 47% respectively.\ud Discussion: The activPAL3 is valid for measuring walking activity in people moderately affected by MS. It is accurate for upright duration regardless of cadence. In participants with slow walking cadences, outcomes of steps taken and walking duration should be interpreted with caution

VEGETATION FIRE FUELS MAPPING IN THE SAN DIEGO CITY CANYONS – A METHOD COMPARISON

Fire risk is a major threat to life, property and natural resources in southern California. Recent fire disasters occurred in autumn 2003 and 2007. Fire risk management deals with these hazards, input data are collected, analyzed and evaluated. One of the most important input data is the vegetation density in the endangered areas. Here we describe methods to map vegetation density forming five hazard classes. The main objective of this study is to explore the benefits of using remote sensed data for the accurate classification of vegetation in San Diego city canyons. Three very high resolution remote sensing data sets (< 1 m) were used in comparison: scanned color infrared film (CIR) airborne, digital multi-spectral airborne (ADS40) and digital multi-spectral satellite imagery (QuickBird). Different classification approaches (e.g. pixel-based, segment-based and knowledge-based) were tested and analyzed to separate the vegetation into five hazard classes. Accuracy assessment indicated low overall accuracies of 58 % on average. With regard to an optimized classification result in particular unsupervised and segment-based classification can be recommended. The overall accuracy for these two methods reached around 62 %. The use of specially selected reference areas for validation helped to increase the accuracies up to 81 %. Also a separating between three instead of five different hazard classes resulted in accuracies around 80 %. Furthermore it could be shown that all three data sets can be used for successful classification procedures. The resulting fire risk maps can help to reduce or prevent fire hazards. The maps are a basis for the brush management of the Fir

Squarks Below the Z

We investigate the possibility that the difference between the measurements of $\alpha_3(M_Z)$ from the hadronic branching ratio of the $Z^0$ and the world average of other measurements is due to the decay of the $Z^0$ into quark, anti-squark, and gluino. Consequences for supersymmetry breaking models are discussed.Comment: 9 pages, 4 figures not include

Testing the Universality of the Stellar IMF with Chandra and HST

The stellar initial mass function (IMF), which is often assumed to be universal across unresolved stellar populations, has recently been suggested to be "bottom-heavy" for massive ellipticals. In these galaxies, the prevalence of gravity-sensitive absorption lines (e.g. Na I and Ca II) in their near-IR spectra implies an excess of low-mass ($m <= 0.5$ $M_\odot$) stars over that expected from a canonical IMF observed in low-mass ellipticals. A direct extrapolation of such a bottom-heavy IMF to high stellar masses ($m >= 8$ $M_\odot$) would lead to a corresponding deficit of neutron stars and black holes, and therefore of low-mass X-ray binaries (LMXBs), per unit near-IR luminosity in these galaxies. Peacock et al. (2014) searched for evidence of this trend and found that the observed number of LMXBs per unit $K$-band luminosity ($N/L_K$) was nearly constant. We extend this work using new and archival Chandra X-ray Observatory (Chandra) and Hubble Space Telescope (HST) observations of seven low-mass ellipticals where $N/L_K$ is expected to be the largest and compare these data with a variety of IMF models to test which are consistent with the observed $N/L_K$. We reproduce the result of Peacock et al. (2014), strengthening the constraint that the slope of the IMF at $m >= 8$ $M_\odot$ must be consistent with a Kroupa-like IMF. We construct an IMF model that is a linear combination of a Milky Way-like IMF and a broken power-law IMF, with a steep slope ($\alpha_1=$ $3.84$) for stars < 0.5 $M_\odot$ (as suggested by near-IR indices), and that flattens out ($\alpha_2=$ $2.14$) for stars > 0.5 $M_\odot$, and discuss its wider ramifications and limitations.Comment: Accepted for publication in ApJ; 7 pages, 2 figures, 1 tabl

Swope Supernova Survey 2017a (SSS17a), the Optical Counterpart to a Gravitational Wave Source

On 2017 August 17, the Laser Interferometer Gravitational-wave Observatory (LIGO) and the Virgo interferometer detected gravitational waves emanating from a binary neutron star merger, GW170817. Nearly simultaneously, the Fermi and INTEGRAL telescopes detected a gamma-ray transient, GRB 170817A. 10.9 hours after the gravitational wave trigger, we discovered a transient and fading optical source, Swope Supernova Survey 2017a (SSS17a), coincident with GW170817. SSS17a is located in NGC 4993, an S0 galaxy at a distance of 40 megaparsecs. The precise location of GW170817 provides an opportunity to probe the nature of these cataclysmic events by combining electromagnetic and gravitational-wave observations.Comment: 25 pages, 10 figures, 2 tables, published today in Scienc

Search for a T-odd, P-even Triple Correlation in Neutron Decay

Background: Time-reversal-invariance violation, or equivalently CP violation, may explain the observed cosmological baryon asymmetry as well as signal physics beyond the Standard Model. In the decay of polarized neutrons, the triple correlation D\cdot(p_{e}\timesp_{\nu}) is a parity-even, time-reversal- odd observable that is uniquely sensitive to the relative phase of the axial-vector amplitude with respect to the vector amplitude. The triple correlation is also sensitive to possible contributions from scalar and tensor amplitudes. Final-state effects also contribute to D at the level of 1e-5 and can be calculated with a precision of 1% or better. Purpose: We have improved the sensitivity to T-odd, P-even interactions in nuclear beta decay. Methods: We measured proton-electron coincidences from decays of longitudinally polarized neutrons with a highly symmetric detector array designed to cancel the time-reversal-even, parity-odd Standard-Model contributions to polarized neutron decay. Over 300 million proton-electron coincidence events were used to extract D and study systematic effects in a blind analysis. Results: We find D = [-0.94\pm1.89(stat)\pm0.97(sys)]e-4. Conclusions: This is the most sensitive measurement of D in nuclear beta decay. Our result can be interpreted as a measurement of the phase of the ratio of the axial-vector and vector coupling constants (CA/CV= |{\lambda}|exp(i{\phi}_AV)) with {\phi}_AV = 180.012{\deg} \pm0.028{\deg} (68% confidence level) or to constrain time-reversal violating scalar and tensor interactions that arise in certain extensions to the Standard Model such as leptoquarks. This paper presents details of the experiment, analysis, and systematic- error corrections.Comment: 21 pages, 22 figure

Patient and public involvement: how much do we spend and what are the benefits?

BACKGROUND AND OBJECTIVES: Patient and public involvement (PPI) is seen as a way of helping to shape health policy and ensure a patient-focused health-care system. While evidence indicates that PPI can improve health-care decision making, it also consumes monetary and non-monetary resources. Given the financial climate, it is important to start thinking about the costs and benefits of PPI and how to evaluate it in economic terms. DESIGN: We conducted a literature review to assess the potential benefits and costs of involvement and the challenges in carrying out an economic evaluation of PPI. RESULTS: The benefits of PPI include effects on the design of new projects or services, on NHS governance, on research design and implementation and on citizenship and equity. Economic evaluation of PPI activities is limited. The lack of an appropriate analytical framework, data recording and understanding of the potential costs and benefits of PPI, especially from participants' perspectives, represent serious constraints on the full evaluation of PPI. CONCLUSIONS: By recognizing the value of PPI, health-care providers and commissioners can embed it more effectively within their organizations. Better knowledge of costs may prompt organizations to effectively plan, execute, evaluate and target resources. This should increase the likelihood of more meaningful activity, avoid tokenism and enhance organizational efficiency and reputation

Comparison of governance approaches for the control of antimicrobial resistance: Analysis of three European countries

Policy makers and governments are calling for coordination to address the crisis emerging from the ineffectiveness of current antibiotics and stagnated pipe-line of new ones – antimicrobial resistance (AMR). Wider contextual drivers and mechanisms are contributing to shifts in governance strategies in health care, but are national health system approaches aligned with strategies required to tackle antimicrobial resistance? This article provides an analysis of governance approaches within healthcare systems including: priority setting, performance monitoring and accountability for AMR prevention in three European countries: England, France and Germany. Advantages and unresolved issues from these different experiences are reported, concluding that mechanisms are needed to support partnerships between healthcare professionals and patients with democratized decision-making and accountability via collaboration. But along with this multi-stakeholder approach to governance, a balance between regulation and persuasion is needed