523 research outputs found
Neutralizing misinformation through inoculation:Exposing misleading argumentation techniques reduces their influence
Misinformation can undermine a well-functioning democracy. For example, public misconceptions about climate change can lead to lowered acceptance of the reality of climate change and lowered support for mitigation policies. This study experimentally explored the impact of misinformation about climate change and tested several pre-emptive interventions designed to reduce the influence of misinformation. We found that false-balance media coverage (giving contrarian views equal voice with climate scientists) lowered perceived consensus overall, although the effect was greater among free-market supporters. Likewise, misinformation that confuses people about the level of scientific agreement regarding anthropogenic global warming (AGW) had a polarizing effect, with free-market supporters reducing their acceptance of AGW and those with low free-market support increasing their acceptance of AGW. However, we found that inoculating messages that (1) explain the flawed argumentation technique used in the misinformation or that (2) highlight the scientific consensus on climate change were effective in neutralizing those adverse effects of misinformation. We recommend that climate communication messages should take into account ways in which scientific content can be distorted, and include preemptive inoculation messages
A Brief History, Status, and Perspective of Modified Oligonucleotides for Chemotherapeutic Applications
The advent of rapid and efficient methods of oligonucleotide synthesis has allowed the design of modified oligonucleotides that are complementary to specific nucleotide sequences in mRNA targets. Such modified oligonucleotides can be used to disrupt the flow of genetic information from transcribed mRNAs to proteins. This antisense strategy has been used to develop therapeutic oligonucleotides against cancer and various infectious diseases in humans. This overview reports recent advances in the application of oligonucleotides as drug candidates, describes the relationship between oligonucleotide modifications and their therapeutic profiles, and provides general guidelines for enhancing oligonucleotide drug properties.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143788/1/cpnc0401.pd
Search for Small Trans-Neptunian Objects by the TAOS Project
The Taiwan-America Occultation Survey (TAOS) aims to determine the number of
small icy bodies in the outer reach of the Solar System by means of stellar
occultation. An array of 4 robotic small (D=0.5 m), wide-field (f/1.9)
telescopes have been installed at Lulin Observatory in Taiwan to simultaneously
monitor some thousand of stars for such rare occultation events. Because a
typical occultation event by a TNO a few km across will last for only a
fraction of a second, fast photometry is necessary. A special CCD readout
scheme has been devised to allow for stellar photometry taken a few times per
second. Effective analysis pipelines have been developed to process stellar
light curves and to correlate any possible flux changes among all telescopes. A
few billion photometric measurements have been collected since the routine
survey began in early 2005. Our preliminary result of a very low detection rate
suggests a deficit of small TNOs down to a few km size, consistent with the
extrapolation of some recent studies of larger (30--100 km) TNOs.Comment: 4 pages, 3 figures, IAU Symposium 23
A geometric approach to time evolution operators of Lie quantum systems
Lie systems in Quantum Mechanics are studied from a geometric point of view.
In particular, we develop methods to obtain time evolution operators of
time-dependent Schrodinger equations of Lie type and we show how these methods
explain certain ad hoc methods used in previous papers in order to obtain exact
solutions. Finally, several instances of time-dependent quadratic Hamiltonian
are solved.Comment: Accepted for publication in the International Journal of Theoretical
Physic
A Binary Lensing Event Toward the LMC: Observations and Dark Matter Implications
The MACHO collaboration has recently analyzed 2.1 years of photometric data
for about 8.5 million stars in the Large Magellanic Cloud (LMC). This analysis
has revealed 8 candidate microlensing events and a total microlensing optical
depth of . This significantly
exceeds the number of events (1.1) and the microlensing optical depth predicted
from known stellar populations: , but it is
consistent with models in which about half of the standard dark halo mass is
composed of Machos of mass \sim 0.5 \msun. One of these 8 events appears to
be a binary lensing event with a caustic crossing that is partially resolved
which allows us to estimate the distance to the lenses. If the source star is
not a short period binary star, then we show that the lens system is very
likely to reside in the LMC. However, if we assume that the optical depth for
LMC-LMC lensing is large enough to account for our entire lensing signal, then
the binary event does not appear to be consistent with lensing of a single LMC
source star by a binary residing in the LMC. Thus, while the binary lens may
indeed reside in the LMC, there is no indication that most of the lenses reside
in the LMC.Comment: 5 pages, 3 postscript figures included; To appear in the Proceedings
of the Dark Matter '96 Conference held in Santa Monica, CA, Feb., 199
A Model for the Development of the Rhizobial and Arbuscular Mycorrhizal Symbioses in Legumes and Its Use to Understand the Roles of Ethylene in the Establishment of these two Symbioses
We propose a model depicting the development of nodulation and arbuscular mycorrhizae. Both processes are dissected into many steps, using Pisum sativum L. nodulation mutants as a guideline. For nodulation, we distinguish two main developmental programs, one epidermal and one cortical. Whereas Nod factors alone affect the cortical program, bacteria are required to trigger the epidermal events. We propose that the two programs of the rhizobial symbiosis evolved separately and that, over time, they came to function together. The distinction between these two programs does not exist for arbuscular mycorrhizae development despite events occurring in both root tissues. Mutations that affect both symbioses are restricted to the epidermal program. We propose here sites of action and potential roles for ethylene during the formation of the two symbioses with a specific hypothesis for nodule organogenesis. Assuming the epidermis does not make ethylene, the microsymbionts probably first encounter a regulatory level of ethylene at the epidermis–outermost cortical cell layer interface. Depending on the hormone concentrations there, infection will either progress or be blocked. In the former case, ethylene affects the cortex cytoskeleton, allowing reorganization that facilitates infection; in the latter case, ethylene acts on several enzymes that interfere with infection thread growth, causing it to abort. Throughout this review, the difficulty of generalizing the roles of ethylene is emphasized and numerous examples are given to demonstrate the diversity that exists in plants
Multi-model finite element scheme for static and free vibration analyses of composite laminated beams
Magnetic Field Generation in Stars
Enormous progress has been made on observing stellar magnetism in stars from
the main sequence through to compact objects. Recent data have thrown into
sharper relief the vexed question of the origin of stellar magnetic fields,
which remains one of the main unanswered questions in astrophysics. In this
chapter we review recent work in this area of research. In particular, we look
at the fossil field hypothesis which links magnetism in compact stars to
magnetism in main sequence and pre-main sequence stars and we consider why its
feasibility has now been questioned particularly in the context of highly
magnetic white dwarfs. We also review the fossil versus dynamo debate in the
context of neutron stars and the roles played by key physical processes such as
buoyancy, helicity, and superfluid turbulence,in the generation and stability
of neutron star fields.
Independent information on the internal magnetic field of neutron stars will
come from future gravitational wave detections. Thus we maybe at the dawn of a
new era of exciting discoveries in compact star magnetism driven by the opening
of a new, non-electromagnetic observational window.
We also review recent advances in the theory and computation of
magnetohydrodynamic turbulence as it applies to stellar magnetism and dynamo
theory. These advances offer insight into the action of stellar dynamos as well
as processes whichcontrol the diffusive magnetic flux transport in stars.Comment: 41 pages, 7 figures. Invited review chapter on on magnetic field
generation in stars to appear in Space Science Reviews, Springe
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