Science and Intractable Conflict

Using illustrative examples, this article describes how science and other types of information often are used in an attempt to settle Conflict. Expectations for science to arbitrate differences may be misplaced, however, and such misuse of science can aggravate and exacerbate Conflict. Instead, effective resolution may be facilitated by focusing on facts that matter, acknowledging the value of varied sorts and sources of information, and recognizing scientific uncertainty

Consensual procedures and the role of science in public decision making

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Architecture, 1988.Bibliography: leaves 262-270.by Connie Patricia Ozawa.Ph.D

Including the Excluded: The Case of Slow Learners at Buloba Primary School, Uganda

This article describes a study of Mathematics teachers at Buloba Primary School in Uganda. The purpose was to analyse the teachers’ perceptions, essential practices for creating inclusive classroom environments for slow learners, and implementation challenges. This quasi-experimental research included a focus group discussion, an interview with the headteacher, three lesson observations and post-observation focus group discussions. The results indicate that the teachers have mixed perceptions and several practices: peer learning, certain teaching methods, linking teaching to real-world applications, seating environment, and providing a threat -free classroom environment. Highlighted challenges include heavy workloads, limited time, inadequate training, mixed classes of both slow and fast learners, inability to identify slow learners, class size and lack of knowledge. It emphasizes the need to define and develop reference frameworks of teacher competencies and institutionalize in-service teacher education programmes through school-based practices and research.Group C: Teacher Professional Developmen

How Well has Land-Use Planning Worked Under Different Governance Regimes? A Case Study in the Portland, OR-Vancouver, WA Metropolitan Area, USA

We examine land use planning outcomes over a 30-year period in the Portland, OR-Vancouver, WA (USA) metropolitan area. The four-county study region enables comparisons between three Oregon counties subject to Oregon’s 1973 Land Use Act (Senate Bill 100) and Clark County, WA which implemented land use planning under Washington’s 1990 Growth Management Act. We describe county-level historical land uses from the mid-1970s to the mid-2000s, including low-density residential and urban development, both outside and inside of current urban growth boundaries. We use difference-in-differences models to test whether differences in the proportions of developed land resulting from implementation of urban growth boundaries are statistically significant and whether they vary between Oregon and Washington. Our results suggest that land use planning and urban growth boundaries now mandated both in Oregon and Washington portions of the study area have had a measurable and statistically significant effect in containing development and conserving forest and agricultural lands in the Portland-Vancouver metropolitan area. Our results also suggest, however, that these effects differ across the four study-area counties, likely owing in part to differences in counties’ initial levels of development, distinctly different land use planning histories, and how restrictive their urban growth boundaries were drawn

Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4

Absence epilepsy, characterized by spike–wave discharges (SWD) in the electroencephalogram, arises from aberrations within the circuitry of the cerebral cortex and thalamus that regulates awareness. The inbred mouse strain C3H/HeJ is prone to absence seizures, with a major susceptibility locus, spkw1, accounting for most of the phenotype. Here we find that spkw1 is associated with a hypomorphic retroviral-like insertion mutation in the Gria4 gene, encoding one of the four amino-3-hydroxy-5-methyl-4isoxazolepropionic acid (AMPA) receptor subunits in the brain. Consistent with this, Gria4 knockout mice also have frequent SWD and do not complement spkw1. In contrast, null mutants for the related gene Gria3 do not have SWD, and Gria3 loss actually lowers SWD of spkw1 homozygotes. Gria3 and Gria4 encode the predominant AMPA receptor subunits in the reticular thalamus, which is thought to play a central role in seizure genesis by inhibiting thalamic relay cells and promoting rebound burst firing responses. In Gria4 mutants, synaptic excitation of inhibitory reticular thalamic neurons is enhanced, with increased duration of synaptic responses—consistent with what might be expected from reduction of the kinetically faster subunit of AMPA receptors encoded by Gria4. These results demonstrate for the first time an essential role for Gria4 in the brain, and suggest that abnormal AMPA receptor-dependent synaptic activity can be involved in the network hypersynchrony that underlies absence seizures

Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression and Promoter Activity Predict Variation

Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many clinically used drugs. We hypothesized that common genetic variation in the proximal promoter regions of transporter genes contribute to observed variation in drug response. A total of 579 polymorphisms were identified in the proximal promoters (−250 to +50 bp) and flanking 5′ sequence of 107 transporters in the ATP Binding Cassette (ABC) and Solute Carrier (SLC) superfamilies in 272 DNA samples from ethnically diverse populations. Many transporter promoters contained multiple common polymorphisms. Using a sliding window analysis, we observed that, on average, nucleotide diversity (π) was lowest at approximately 300 bp upstream of the transcription start site, suggesting that this region may harbor important functional elements. The proximal promoters of transporters that were highly expressed in the liver had greater nucleotide diversity than those that were highly expressed in the kidney consistent with greater negative selective pressure on the promoters of kidney transporters. Twenty-one promoters were evaluated for activity using reporter assays. Greater nucleotide diversity was observed in promoters with strong activity compared to promoters with weak activity, suggesting that weak promoters are under more negative selective pressure than promoters with high activity. Collectively, these results suggest that the proximal promoter region of membrane transporters is rich in variation and that variants in these regions may play a role in interindividual variation in drug disposition and response

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Science in Environmental Conflicts

Science plays a major part in environmental conflict. How that role is defined is determined by the human actors engaged in the conflict and the legal and institutional constructs that structure discourse. This article begins by tracing the authority invested in science to ideological assumptions about scientific methodology. Then, four common roles for science in environmental conflict (discoverer, mechanism of accountability, shield, and toql of persuasion), are described. These roles are increasingly unproductive in resolving environmental conflict, partly due to the misfit between the actual conduct of science and its ideal. This article proposes that a new role, one that is more consistent with a social constructionist view of science, has been crafted as a byproduct of decision-making innovations that prescribe explicit negotiations among representatives of groups engaged in an environmental dispute. As a tool offacilitation, science may be used more constructively to resolve environmental disput

An Evaluation of the Oregon Department of Transportation’s (ODOT) Environmental Streamlining Efforts: A Focus on CETAS

The Oregon Department of Transportation responded to the federal call in the late 1990s to streamline the National Environmental Policy Act (NEPA) by (1) implementing organizational and procedural changes internal to the agency, (2) funding ODOT-dedicated staff positions in state and federal resource agencies, and (3) convening regular meetings with state and federal agencies with NEPA-related regulatory responsibilities. This latter effort evolved into the CETAS (Collaborative Environmental and Transportation Agreement for Streamlining) process that includes a management and a technical team element. This document reports an assessment of the effectiveness of these efforts. Phase I of the study was designed to document the perceptions and behaviors in ODOT employees at the onset of ODOT organizational and procedural changes and to compare the responses to ones obtained from ODOT employees after some passage of time. The time period covered in this section is roughly Fall 2001 to Fall 2003. Phase II of the study was designed to assess the effectiveness of the CETAS process and documents factors that affect project timelines in Oregon state highway projects for pre-CETAS projects. The third section of this document includes an analysis of the CETAS process based on interviews conducted in the spring and summer of 2004

Strengthening Your Community by Tackling Challenges Together: Lessons from the High Desert Partnership

The people of Harney County, Oregon, have a story to tell about healing decades of conflict and coming together to ensure their community survives and thrives. Harney County, located in the southeast corner of the state, is the largest and one of the least populated of Oregon’s counties. It is a place of wide open spaces, with sagebrush deserts, rich wetlands, expansive alkali flats, stark mountains, and stately ponderosa pine forests. The economy relies heavily on the land for farming, ranching, and forestry. Yet the majority of Harney’s land is publicly owned. Historically, that was a recipe for heated disagreements around public land management, private land use, and environmental preservation. A few visionary thinkers in Harney County saw a way around the conflict by bringing community members, government, and environmental groups together to help them discover they had more in common than they had that divided them. What developed was a community-wide commitment to working together to make Harney County better. The High Desert Partnership (HDP) formed to support a wide range of local collaborative projects from managing wetlands to improving opportunities for youth. This guide shares the HDP’s formula for getting things done. Their hope is that other communities that are ready to create a lasting approach to tackling tough issues will benefit from what Harney County has learned