806 research outputs found
High sensitivity phonon-mediated kinetic inductance detector with combined amplitude and phase read-out
The development of wide-area cryogenic light detectors with good energy
resolution is one of the priorities of next generation bolometric experiments
searching for rare interactions, as the simultaneous read-out of the light and
heat signals enables background suppression through particle identification.
Among the proposed technological approaches for the phonon sensor, the
naturally-multiplexed Kinetic Inductance Detectors (KIDs) stand out for their
excellent intrinsic energy resolution and reproducibility. To satisfy the large
surface requirement (several cm) KIDs are deposited on an insulating
substrate that converts the impinging photons into phonons. A fraction of
phonons is absorbed by the KID, producing a signal proportional to the energy
of the original photons. The potential of this technique was proved by the
CALDER project, that reached a baseline resolution of 1547 eV RMS by
sampling a 22 cm Silicon substrate with 4 Aluminum KIDs. In this
paper we present a prototype of Aluminum KID with improved geometry and quality
factor. The design improvement, as well as the combined analysis of amplitude
and phase signals, allowed to reach a baseline resolution of 824 eV by
sampling the same substrate with a single Aluminum KID
The polarizability of the pion: no conflict between dispersion theory and chiral perturbation theory
Recent attempts to determine the pion polarizability by dispersion relations
yield values that disagree with the predictions of chiral perturbation theory.
These dispersion relations are based on specific forms for the absorptive part
of the Compton amplitudes. The analytic properties of these forms are examined,
and the strong enhancement of intermediate-meson contributions is shown to be
connected with spurious singularities. If the basic requirements of dispersion
relations are taken into account, the results of dispersion theory and
effective field theory are not inconsistent.Comment: 30 pages, 8 figures, 6 table
Revealing protein-lncRNA interaction
Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs are often able to bind a large number of different RNAs. The currently available knowledge is already drawing an intricate network of interactions, whose deregulation is frequently associated to pathological states. Several different techniques were developed in the past years to obtain protein-RNA binding data in a high-throughput fashion. In parallel, in silico inference methods were developed for the accurate computational prediction of the interaction of RBP-lncRNA pairs. The field is growing rapidly, and it is foreseeable that in the near future, the protein-lncRNA interaction network will rise, offering essential clues for a better understanding of lncRNA cellular mechanisms and their disease-associated perturbations
Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation
Current research into original therapies to treat intestinal inflammation is focusing on no-drug therapies. KLD is a mixture of krill oil (KO), probiotic Lactobacillus reuteri (LR), and vitamin D (VitD3). The aim of this study was to assess in vitro and in vivo the potential cooperative effects of KLD in reducing gut inflammation. Colorectal adenocarcinoma cell lines, CACO2 and HT29, and C57BL/6 mice were used for in vitro and in vivo analyses, respectively. Cells were exposed to cytomix (interferon gamma + tumour necrosis factor alpha (TNF-a)) to induce inflammation or co-exposed to cytomix and KO, LR and VitD3 alone or to cytomix and KLD. Animals were treated for 7 days with dextran sodium sulphate (DSS) to induce colitis or with DSS and KLD. In vitro assays: F-actin expression was analysed by immunofluorescence; scratch test and trans-epithelial electric resistance test were performed to measure wound healing; adhesion/invasion assays of adhesive and invasive Escherichia coli (AIEC) bacteria were made; mRNA expression of TNF-α, interleukin (IL)-8 and vitamin D receptor (VDR) was detected by quantitative PCR. In vivo assays: body weight, clinical score, histological score and large intestine weight and length were estimated; mRNA expression of TNF-α, IL-1ß, IL-6, IL-10 by quantitative PCR; VDR expression was detected by quantitative PCR and immunohistochemistry. In vitro: KLD restores epithelial cell-cell adhesion and mucosal healing during inflammation, while decreases the adhesiveness and invasiveness of AIEC bacteria and TNF-α and IL-8 mRNA expression and increases VDR expression. In vivo: KLD significantly improves body weight, clinical score, histological score and large intestine length of mice with DSS-induced colitis and reduces TNF-α, IL-1ß and IL-6 mRNA levels, while increases IL-10 mRNA and VDR levels. KLD has significant effects on the intestinal mucosa, strongly decreasing inflammation, increasing epithelial restitution and reducing pathogenicity of harmful commensal bacteria
Decision analysis for the determination of biomass in the territory Tuscia Romana by geographic information system and forest management plans
The growing interest in the development of chains for the use of agroforestry biomass for energy demand, is due to the awareness they are a crucial element to mitigate the global climatic change effects. The true effort is to have a reliable estimation of biomass availability by some instruments like forest management plans, which allow to locate the forest supply and to know the forest biomass availability in a medium period. In this paper we carried out a decision analysis by geographic information system, in Tuscia Romana area comprising 11 municipalities for a total amount of 813 km2. An estimation was carried out taking into account the bibliographic data on the analyzed species, reporting the biomass in weight taken out by the forest cut utilization. A comparison was also performed in field on chestnut trees cut in a sampling area near Bracciano and in a close sawmill. The results show long, medium and short-term dynamics, but some critical points were found related to the process of estimation and to the real procurement of biomass in some years. The results suggest to be care in a possible project of a biomass plant
Development of Lumped Element Kinetic Inductance Detectors for the W-Band
We are developing a Lumped Element Kinetic Inductance Detector (LEKID) array
able to operate in the W-band (75-110 GHz) in order to perform ground-based
Cosmic Microwave Background (CMB) and mm-wave astronomical observations. The
W-band is close to optimal in terms of contamination of the CMB from Galactic
synchrotron, free-free, and thermal interstellar dust. In this band, the
atmosphere has very good transparency, allowing interesting ground-based
observations with large (>30 m) telescopes, achieving high angular resolution
(<0.4 arcmin). In this work we describe the startup measurements devoted to the
optimization of a W-band camera/spectrometer prototype for large aperture
telescopes like the 64 m SRT (Sardinia Radio Telescope). In the process of
selecting the best superconducting film for the LEKID, we characterized a 40 nm
thick Aluminum 2-pixel array. We measured the minimum frequency able to break
CPs (i.e. ) obtaining
GHz, that corresponds to a critical temperature of 1.31 K. This is not suitable
to cover the entire W-band. For an 80 nm layer the minimum frequency decreases
to 93.2 GHz, which corresponds to a critical temperature of 1.28 K; this value
is still suboptimal for W-band operation. Further increase of the Al film
thickness results in bad performance of the detector. We have thus considered a
Titanium-Aluminum bi-layer (10 nm thick Ti + 25 nm thick Al, already tested in
other laboratories), for which we measured a critical temperature of 820 mK and
a cut-on frequency of 65 GHz: so this solution allows operation in the entire
W-band.Comment: 16th International Workshop on Low Temperature Detectors, Grenoble
20-24 July 2015, Journal of Low Temperature Physics, Accepte
New application of superconductors: high sensitivity cryogenic light detectors
In this paper we describe the current status of the CALDER project, which is
developing ultra-sensitive light detectors based on superconductors for
cryogenic applications. When we apply an AC current to a superconductor, the
Cooper pairs oscillate and acquire kinetic inductance, that can be measured by
inserting the superconductor in a LC circuit with high merit factor.
Interactions in the superconductor can break the Cooper pairs, causing sizable
variations in the kinetic inductance and, thus, in the response of the LC
circuit. The continuous monitoring of the amplitude and frequency modulation
allows to reconstruct the incident energy with excellent sensitivity. This
concept is at the basis of Kinetic Inductance Detectors (KIDs), that are
characterized by natural aptitude to multiplexed read-out (several sensors can
be tuned to different resonant frequencies and coupled to the same line),
resolution of few eV, stable behavior over a wide temperature range, and ease
in fabrication. We present the results obtained by the CALDER collaboration
with 2x2 cm2 substrates sampled by 1 or 4 Aluminum KIDs. We show that the
performances of the first prototypes are already competitive with those of
other commonly used light detectors, and we discuss the strategies for a
further improvement
Characterization of the KID-Based Light Detectors of CALDER
The aim of the Cryogenic wide-Area Light Detectors with Excellent Resolution
(CALDER) project is the development of light detectors with active area of
cm and noise energy resolution smaller than 20 eV RMS,
implementing phonon-mediated kinetic inductance detectors. The detectors are
developed to improve the background suppression in large-mass bolometric
experiments such as CUORE, via the double read-out of the light and the heat
released by particles interacting in the bolometers. In this work, we present
the characterization of the first light detectors developed by CALDER. We
describe the analysis tools to evaluate the resonator parameters (resonant
frequency and quality factors) taking into account simultaneously all the
resonance distortions introduced by the read-out chain (as the feed-line
impedance and its mismatch) and by the power stored in the resonator itself. We
detail the method for the selection of the optimal point for the detector
operation (maximizing the signal-to-noise ratio). Finally, we present the
response of the detector to optical pulses in the energy range of 0-30 keV
Energy resolution and efficiency of phonon-mediated Kinetic Inductance Detectors for light detection
The development of sensitive cryogenic light detectors is of primary interest
for bolometric experiments searching for rare events like dark matter
interactions or neutrino-less double beta decay. Thanks to their good energy
resolution and the natural multiplexed read-out, Kinetic Inductance Detectors
(KIDs) are particularly suitable for this purpose. To efficiently couple
KIDs-based light detectors to the large crystals used by the most advanced
bolometric detectors, active surfaces of several cm are needed. For this
reason, we are developing phonon-mediated detectors. In this paper we present
the results obtained with a prototype consisting of four 40 nm thick aluminum
resonators patterned on a 22 cm silicon chip, and calibrated with
optical pulses and X-rays. The detector features a noise resolution
eV and an (182) efficiency.Comment: 5 pages, 5 figure
- …