Current status of bird pest species in agroecosystems of Buenos Aires province, central Argentina

Codesido, M., Bilenca, D

A contribution from Barn Owl pellets analysis to known micromammalian distributions in Buenos Aires province, Argentina

Fil:González-Fischer, C.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Codesido, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Bilenca, D.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina

Habitat use by armadillos in agroecosystems of central Argentina: does plot identity matter?

In agroecosystems, the use of cultivated plots by mammals depends on habitat structure as well as on the degree of species specialization. In the Pampas of Argentina, during the last 2-3 decades, there has been a continuing expansion of cropland. The aim of this study was to analyze how the identity and characteristics of agricultural plots may have affected the activity of 2 species of armadillos (Chaetophractus villosus and Dasypus hybridus) in a rural landscape. We carried out 4 sampling sessions between December 2011 and June 2013, surveying 175 plots during spring-summer and 194 during fall at 25 different sites in the Pampas of Buenos Aires province, Argentina. In each plot, we surveyed for signs (burrows and holes) along a 600×6 m transect in order to assess armadillo activity and measured 4 habitat structural variables. As expected, there were structural differences between types of agricultural plots. Across all plots, a total of 6,654 armadillo signs were found (C. villosus = 5,009, D. hybridus = 1,645). Generalized linear mixed models revealed that during both seasons, the type of plot explained much of the variation in armadillo activity, except during spring-summer for D. hybridus. C. villosus had higher use of plots with a longer history of non-tillage (e.g., soybean), while there was more evidence of D. hybridus activity in plots with less human intervention (e.g., grasslands), especially during fall. Overall, D. hybridus and C. villosus were more sensitive to the particular structural features of plots rather than to the kind of land use practiced (crop field or rangeland). These results have important implications for future management decisions in the Pampas region because during the last decades, farming of soybeans has expanded at the expense of grasslands, and this change appears to have differentially affected these 2 species of armadillos.Centro de Estudios Parasitológicos y de VectoresFacultad de Ciencias Naturales y Muse

Habitat use by armadillos in agroecosystems of central Argentina: does plot identity matter?

In agroecosystems, the use of cultivated plots by mammals depends on habitat structure as well as on the degree of species specialization. In the Pampas of Argentina, during the last 2-3 decades, there has been a continuing expansion of cropland. The aim of this study was to analyze how the identity and characteristics of agricultural plots may have affected the activity of 2 species of armadillos (Chaetophractus villosus and Dasypus hybridus) in a rural landscape. We carried out 4 sampling sessions between December 2011 and June 2013, surveying 175 plots during spring-summer and 194 during fall at 25 different sites in the Pampas of Buenos Aires province, Argentina. In each plot, we surveyed for signs (burrows and holes) along a 600×6 m transect in order to assess armadillo activity and measured 4 habitat structural variables. As expected, there were structural differences between types of agricultural plots. Across all plots, a total of 6,654 armadillo signs were found (C. villosus = 5,009, D. hybridus = 1,645). Generalized linear mixed models revealed that during both seasons, the type of plot explained much of the variation in armadillo activity, except during spring-summer for D. hybridus. C. villosus had higher use of plots with a longer history of non-tillage (e.g., soybean), while there was more evidence of D. hybridus activity in plots with less human intervention (e.g., grasslands), especially during fall. Overall, D. hybridus and C. villosus were more sensitive to the particular structural features of plots rather than to the kind of land use practiced (crop field or rangeland). These results have important implications for future management decisions in the Pampas region because during the last decades, farming of soybeans has expanded at the expense of grasslands, and this change appears to have differentially affected these 2 species of armadillos.Centro de Estudios Parasitológicos y de VectoresFacultad de Ciencias Naturales y Muse

Association of creatine kinase and skin toxicity in phase I trials of anticancer agents.

BACKGROUND: We investigated the association between skin rash and plasma creatine kinase (CK) levels in oncology phase I trials. METHODS: We analysed data from 295 patients treated at our institution within 25 phase I trials which included CK measurements in the protocol. Trials involved drugs targeting EGFR/HER2, m-TOR, VEGFR, SRC/ABL, aurora kinase, BRAF/MEK, PARP, CDK, A5B1 integrin, as well as oncolytic viruses and vascular disrupting agents. RESULTS: Creatine kinase measurements were available for 278 patients. The highest levels of plasma CK during the trial were seen among patients with Grade (G) 2/3 rash (median 249 U l(-1)) compared with G1 (median 81 U l(-1)) and no rash (median 55 U l(-1)) (P<0.001). There was a significant reduction in CK after the rash resolved (mean 264.2 vs 100.1; P=0.012) in 25 patients, where serial CK values were available. In vitro exposure of human keratinocytes to EGFR, MEK and a PI3Kinase/m-TOR inhibitor led to the increased expression of CK-brain and not CK-muscle or mitochondrial-CK. CONCLUSION: Plasma CK elevation is associated with development of skin rash caused by novel anticancer agents. This should be studied further to characterise different isoforms as this will change the way we report adverse events in oncology phase I clinical trials

Stability in and Correlation between Factors Influencing Genetic Quality of Seed Lots in Seed Orchard of Pinus tabuliformis Carr. over a 12-Year Span

Coniferous seed orchards require a long period from initial seed harvest to stable seed production. Differential reproductive success and asynchrony are among the main factors for orchard crops year-to-year variation in terms of parental gametic contribution and ultimately the genetic gain. It is fundamental in both making predictions about the genetic composition of the seed crop and decisions about orchard roguing and improved seed orchard establishment. In this paper, a primary Chinese pine seed orchard with 49 clones is investigated for stability, variation and correlation analysis of factors which influence genetic quality of the seed lots from initial seed harvest to the stable seed production over a 12 years span. Results indicated that the reproductive synchrony index of pollen shedding has shown to be higher than that of the strobili receptivity, and both can be drastically influenced by the ambient climate factors. Reproductive synchrony index of the clones has certain relative stability and it could be used as an indication of the seed orchard status during maturity stage; clones in the studied orchard have shown extreme differences in terms of the gametic and genetic contribution to the seed crop at the orchard's early production phase specifically when they severe as either female or male parents. Those differences are closely related to clonal sex tendency at the time of orchard's initial reproduction. Clonal gamete contribution as male and female parent often has a negative correlation. Clone utilization as pollen, seed or both pollen and seed donors should consider the role it would play in the seed crop; due to numerous factors influencing on the mating system in seed orchards, clonal genetic contribution as male parent is uncertain, and it has major influence on the genetic composition in the seed orchard during the initial reproductive and seed production phase

Inhaled Methoxyflurane Provides Greater Analgesia and Faster Onset of Action Versus Standard Analgesia in Patients With Trauma Pain: InMEDIATE: A Randomized Controlled Trial in Emergency Departments

STUDY OBJECTIVE: The objective of the InMEDIATE study was to evaluate the change in intensity of traumatic pain over the first 20 min in adult patients treated with methoxyflurane versus standard analgesic treatment in Spain. This the first randomized, active-controlled, multicenter trial of methoxyflurane in the emergency setting in Europe. METHODS: This was a randomized, controlled study that enrolled adult patients with acute moderate to severe (score >/=4 on the 11-point Numeric Rating Scale) trauma-associated pain in 14 Spanish emergency departments. Patients were randomized 1:1 to methoxyflurane (up to 2x3 mL) or standard analgesic treatment. Coprimary endpoints were the change from baseline in Numeric Rating Scale pain intensity score during the first 20 minutes of treatment and time to first pain relief. RESULTS: Three hundred five patients were randomized (methoxyflurane 156; standard analgesic treatment 149). Most patients in the standard analgesic treatment group (70%) received intravenous first-step analgesics and 9.4% of patients were treated with opioids. Mean decrease from baseline in Numeric Rating Scale pain intensity score was greater for methoxyflurane than standard analgesic treatment at all points, with a significant treatment difference overall up to 20 minutes (repeated-measures model 2.47 versus 1.39; treatment difference 1.00; 95% confidence interval 0.84 to 1.32). Median time to first pain relief was significantly shorter for methoxyflurane than standard analgesic treatment (3 versus 10 minutes). Methoxyflurane achieved better patient and clinician ratings for pain control and comfort of treatment than standard analgesic treatment and exceeded patient and clinician expectations of treatment in, respectively, 77% and 72% of cases compared with 38% and 19% for standard analgesic treatment. CONCLUSION: These results support consideration of methoxyflurane as a nonnarcotic, easy-to-administer, rapid-acting, first-line alternative to currently available analgesic treatments for trauma pain

Inhaled Methoxyflurane Provides Greater Analgesia and Faster Onset of Action Versus Standard Analgesia in Patients With Trauma Pain: InMEDIATE: A Randomized Controlled Trial in Emergency Departments

Study objective: The objective of the InMEDIATE study was to evaluate the change in intensity of traumatic pain over the first 20 min in adult patients treated with methoxyflurane versus standard analgesic treatment in Spain. This the first randomized, active-controlled, multicenter trial of methoxyflurane in the emergency setting in Europe. Methods: This was a randomized, controlled study that enrolled adult patients with acute moderate to severe (score >= 4 on the 11-point Numeric Rating Scale) trauma-associated pain in 14 Spanish emergency departments. Patients were randomized 1:1 to methoxyflurane (up to 2x3 mL) or standard analgesic treatment. Coprimary endpoints were the change from baseline in Numeric Rating Scale pain intensity score during the first 20 minutes of treatment and time to first pain relief. Results: Three hundred five patients were randomized (methoxyflurane 156; standard analgesic treatment 149). Most patients in the standard analgesic treatment group (70%) received intravenous first-step analgesics and 9.4% of patients were treated with opioids. Mean decrease from baseline in Numeric Rating Scale pain intensity score was greater for methoxyflurane than standard analgesic treatment at all points, with a significant treatment difference overall up to 20 minutes (repeated-measures model 2.47 versus 1.39; treatment difference 1.00; 95% confidence interval 0.84 to 1.32). Median time to first pain relief was significantly shorter for methoxyflurane than standard analgesic treatment (3 versus 10 minutes). Methoxyflurane achieved better patient and clinician ratings for pain control and comfort of treatment than standard analgesic treatment and exceeded patient and clinician expectations of treatment in, respectively, 77% and 72% of cases compared with 38% and 19% for standard analgesic treatment. Conclusion: These results support consideration of methoxyflurane as a nonnarcotic, easy-to-administer, rapid-acting, first-line alternative to currently available analgesic treatments for trauma pain

State of emergency medicine in Spain

Spain has universal public health care coverage. Emergency care provisions are offered to patients in different modalities and levels according to the characteristics of the medical complaint: at primary care centers (PCC), in an extrahospital setting by emergency medical services (EMS) and at hospital emergency departments (ED). We have more than 3,000 PCCs, which are run by family doctors (general practitioners) and pediatricians. On average, there is 1 PCC for every 15,000 to 20,000 inhabitants, and every family doctor is in charge of 1,500 to 2,000 citizens, although less populated zones tend to have lower ratios. Doctors spend part of their duty time in providing emergency care to their own patients. While not fully devoted to emergency medicine (EM) practice, they do manage minor emergencies. However, Spanish EMSs contribute hugely to guarantee population coverage in all situations. These EMS are run by EM technicians (EMT), nurses and doctors, who usually work exclusively in the emergency arena. EDs dealt with more than 25 million consultations in 2008, which implies, on average, that one out of two Spaniards visited an ED during this time. They are usually equipped with a wide range of diagnostic tools, most including ultrasonography and computerized tomography scans. The academic and training background of doctors working in the ED varies: nearly half lack any structured specialty residence training, but many have done specific master or postgraduate studies within the EM field. The demand for emergency care has grown at an annual rate of over 4% during the last decade. This percentage, which was greater than the 2% population increase during the same period, has outpaced the growth in ED capacity. Therefore, Spanish EDs become overcrowded when the system exerts minimal stress. Despite the high EM caseload and the potential severity of the conditions, training in EM is still unregulated in Spain. However, in April 2009 the Spanish Minister of Health announced the imminent approval of an EM specialty, allowing the first EM resident to officially start in 2011. Spanish emergency physicians look forward to the final approval, which will complete the modernization of emergency health care provision in Spain