Une femme nouvelle pour une France nouvelle ?

Cet article considère l’expérience des femmes en France après la Libération, partant de la déclaration faite en 1945 qu’une « nouvelle femme » allait surgir de la guerre. L’article examine les trois rôles attribuées aux femmes (citoyenne, travailleuse et mère) et les trois discours qui s’y attachent. Ces discours contribuent à limiter les potentialités  des femmes  qui ne jouissent pas d’une participation à la vie publique à part entière. Les changements, qui deviendront visibles dans la vie des femmes plus tard, n’apparaissent pas dans les années de l’après-Libération, années où les femmes sont systématique-ment déçues par les mesures prises (ou non prises) à leur égard.Claire Duchen : New woman for a new France ?This article considers the experiences of women in France after the Liberation, taking as a starting point the notion that a new woman might emerge from the war. The article discusses the three roles attributed to women (citizen, worker and mother) and explores the way in which the three discourses seemed to work to limit and circumscribe women’s lives and potential. The changes that become visible in women’s lives only appear later in the 1960s ; the years of the liberation were years in which women’s hopes were consistently disappointed

Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease, considered to be autoimmune in origin. Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity. Here we investigated the expression of citrullinated proteins in active MS lesions, MS normal appearing white matter and control brain white matter. We demonstrate increased citrullinated GFAP and MBP by immunohistochemistry and western blotting in areas of ongoing demyelination, suggesting a pivotal role for deimination of GFAP and MBP in MS pathogenesis MS

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

The policing of desire in the Gabrielle Russier affair

Gabrielle Russier’s persecution by the French state and its apparatuses for her love affair with a much younger male pupil, culminating in her suicide in 1969, is a now largely forgotten but still important part of the history of 1968 and its aftermath. The article retraces the affaire and its reproductions (which include a feature film starring Annie Girardot),and considers its implications for questions of power, desire, privacy, policing and the role of the educational institution. Would a new affaire Russier be possible today? How would it be differently treated in Britain or the US, and what questions does this raise about different social and institutional determinants in these countries

Multiphoton Imaging of the Functioning Kidney

Translating discoveries made in isolated renal cells and tubules to the in vivo situation requires the assessment of cellular function in intact live organs. Multiphoton imaging is a form of fluorescence microscopy that is ideally suited to working with whole tissues and organs, but adequately loading cells with fluorescence dyes in vivo remains a challenge. We found that recirculation of fluorescence dyes in the rat isolated perfused kidney (IPK) resulted in levels of intracellular loading that would be difficult to achieve in vivo. This technique allowed the imaging of tubular cell structure and function with multiphoton microscopy in an intact, functioning organ. We used this approach to follow processes in real time, including (1) relative rates of reactive oxygen species (ROS) production in different tubule types, (2) filtration and tubular uptake of low-molecular-weight dextrans and proteins, and (3) the effects of ischemia-reperfusion injury on mitochondrial function and cell structure. This study demonstrates that multiphoton microscopy of the isolated perfused kidney is a powerful technique for detailed imaging of cell structure and function in an intact organ