Effective radiative forcing in a GCM with fixed surface temperatures

Effective radiative forcing (ERF) is evaluated in the ACCESS1.0 General Circulation Model (GCM) with fixed land and sea‐surface‐temperatures as well as sea‐ice. The 4xCO2 ERF is 8.0 Wm‐2. In contrast, a typical ERF experiment with only fixed sea‐surface‐temperatures (SST) and sea‐ice gives rise to an ERF of only 7.0 Wm‐2. This difference arises due to the influence of land warming in the commonly used fixed‐SST ERF experimental design, which results in: (i) increased emission of longwave radiation to space from the land surface (‐0.45 Wm‐2) and troposphere (‐0.90 Wm‐2), (ii) reduced land snow‐cover and albedo (+0.17 Wm‐2), (iii) increased water‐vapour (+0.49 Wm‐2), and (iv) a cloud adjustment (‐0.26 Wm‐2) due to reduced stability and cloudiness over land (positive ERF) counteracted by increased lower tropospheric stability and marine cloudiness over oceans (negative ERF) . The sum of these radiative adjustments to land warming is to reduce the 4xCO2 ERF in fixed‐SST experiments by ∼1.0 Wm‐2. CO2 stomatal effects are quantified and found to contribute just over half of the land warming effect and adjustments in the fixed‐SST ERF experimental design in this model. The basic physical mechanisms in response to land warming are confirmed in a solar ERF experiment. We test various methods that have been proposed to account for land warming in fixed‐SST ERFs against our GCM results and discuss their strengths and weaknesses

Narrative and Cognitive Modeling: Insights From Beckett Exploring Mind's Complexity

Complex systems exacerbate a common problem for scientific enquiry: the difficulty of creating models able to discriminate fundamental elements or patterns from random behaviours or corollary components in the event or process at issue. This chapter argues that a similar tension between order and randomness has been a chief modelling problem of Samuel Beckett’s narratives, tied to his interest in a specific kind of complex system (the mind) and its emergent properties (consciousness and the narrative sense of self). Bulding on narratology, complex system frameworks, cognitive theories of emergence and of scientific modelling, this chapter introduces the idea of “fictional cognitive modelling”. Through this concept, the chapter analyses Beckett’s treatment of narrative devices as formal tools for the creation of “exploratory models” able to atomise the emerging unity of conscious experience and of a narrative sense of self into its core components (defined as the “narrative dynamic core”). It concludes by suggesting that Beckett’s narrative method shows how literature can occupy a proper position in the investigation and exploration of complex systems

Genome-Wide Association Analysis Identifies a Mutation in the Thiamine Transporter 2 (SLC19A3) Gene Associated with Alaskan Husky Encephalopathy

Alaskan Husky Encephalopathy (AHE) has been previously proposed as a mitochondrial encephalopathy based on neuropathological similarities with human Leigh Syndrome (LS). We studied 11 Alaskan Husky dogs with AHE, but found no abnormalities in respiratory chain enzyme activities in muscle and liver, or mutations in mitochondrial or nuclear genes that cause LS in people. A genome wide association study was performed using eight of the affected dogs and 20 related but unaffected control AHs using the Illumina canine HD array. SLC19A3 was identified as a positional candidate gene. This gene controls the uptake of thiamine in the CNS via expression of the thiamine transporter protein THTR2. Dogs have two copies of this gene located within the candidate interval (SLC19A3.2 – 43.36–43.38 Mb and SLC19A3.1 – 43.411–43.419 Mb) on chromosome 25. Expression analysis in a normal dog revealed that one of the paralogs, SLC19A3.1, was expressed in the brain and spinal cord while the other was not. Subsequent exon sequencing of SLC19A3.1 revealed a 4bp insertion and SNP in the second exon that is predicted to result in a functional protein truncation of 279 amino acids (c.624 insTTGC, c.625 C>A). All dogs with AHE were homozygous for this mutation, 15/41 healthy AH control dogs were heterozygous carriers while 26/41 normal healthy AH dogs were wild type. Furthermore, this mutation was not detected in another 187 dogs of different breeds. These results suggest that this mutation in SLC19A3.1, encoding a thiamine transporter protein, plays a critical role in the pathogenesis of AHE.University of California, Davis. School of Veterinary Medicine. Center for Companion Animal Healt

Developmental perspectives on interpersonal affective touch

In the last decade, philosophy, neuroscience and psychology alike have paid increasing attention to the study of interpersonal affective touch, which refers to the emotional and motivational facets of tactile sensation. Some aspects of affective touch have been linked to a neurophysiologically specialised system, namely the C tactile (CT) system. While the role of this sys-tem for affiliation, social bonding and communication of emotions have been widely investigated, only recently researchers have started to focus on the potential role of interpersonal affective touch in acquiring awareness of the body as our own, i.e. as belonging to our psychological ‘self’. We review and discuss recent developmental and adult findings, pointing to the central role of interpersonal affective touch in body awareness and social cognition in health and disorders. We propose that interpersonal affective touch, as an interoceptive modality invested of a social nature, can uniquely contribute to the ongoing debate in philosophy about the primacy of the relational nature of the minimal self

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Identification of NAD(P)H Quinone Oxidoreductase Activity in Azoreductases from P. aeruginosa: Azoreductases and NAD(P)H Quinone Oxidoreductases Belong to the Same FMN-Dependent Superfamily of Enzymes

Water soluble quinones are a group of cytotoxic anti-bacterial compounds that are secreted by many species of plants, invertebrates, fungi and bacteria. Studies in a number of species have shown the importance of quinones in response to pathogenic bacteria of the genus Pseudomonas. Two electron reduction is an important mechanism of quinone detoxification as it generates the less toxic quinol. In most organisms this reaction is carried out by a group of flavoenzymes known as NAD(P)H quinone oxidoreductases. Azoreductases have previously been separate from this group, however using azoreductases from Pseudomonas aeruginosa we show that they can rapidly reduce quinones. Azoreductases from the same organism are also shown to have distinct substrate specificity profiles allowing them to reduce a wide range of quinones. The azoreductase family is also shown to be more extensive than originally thought, due to the large sequence divergence amongst its members. As both NAD(P)H quinone oxidoreductases and azoreductases have related reaction mechanisms it is proposed that they form an enzyme superfamily. The ubiquitous and diverse nature of azoreductases alongside their broad substrate specificity, indicates they play a wide role in cellular survival under adverse conditions

‘A new occasion, a new term of relation’: Samuel Beckett and T. S. Eliot

This essay examines the understudied relationship between T. S. Eliot and Samuel Beckett. In the first part of this essay, previous critical treatments of this relationship are considered and factual corrections are made where error has been introduced regarding remarks by Beckett on Eliot. This essay then explores Beckett’s treatment of what he identifies as two distinct versions of Eliot: the early twentieth-century experimental writer of such poems as The Waste Land; and the critic-publisher of The Criterion, Faber & Faber, and the producer of what Beckett labelled a ‘professorial’ approach to poetry. In doing so, this essay considers how the conflicts between Beckett’s rejection of Eliot as a critic and his more ambivalent treatment of Eliot as a poet allow for an exploration of the tensions that are central to modernism, and how this impacts the configuration of both Eliot and Beckett within what has come to be thought of as ‘Late Modernism’