Cloud WorkBench - Infrastructure-as-Code Based Cloud Benchmarking

To optimally deploy their applications, users of Infrastructure-as-a-Service clouds are required to evaluate the costs and performance of different combinations of cloud configurations to find out which combination provides the best service level for their specific application. Unfortunately, benchmarking cloud services is cumbersome and error-prone. In this paper, we propose an architecture and concrete implementation of a cloud benchmarking Web service, which fosters the definition of reusable and representative benchmarks. In distinction to existing work, our system is based on the notion of Infrastructure-as-Code, which is a state of the art concept to define IT infrastructure in a reproducible, well-defined, and testable way. We demonstrate our system based on an illustrative case study, in which we measure and compare the disk IO speeds of different instance and storage types in Amazon EC2

Revealing the Vicious Circle of Disengaged User Acceptance: A SaaS Provider's Perspective

User acceptance tests (UAT) are an integral part of many different software engineering methodologies. In this paper, we examine the influence of UATs on the relationship between users and Software-as-a-Service (SaaS) applications, which are continuously delivered rather than rolled out during a one-off signoff process. Based on an exploratory qualitative field study at a multinational SaaS provider in Denmark, we show that UATs often address the wrong problem in that positive user acceptance may actually indicate a negative user experience. Hence, SaaS providers should be careful not to rest on what we term disengaged user acceptance. Instead, we outline an approach that purposefully queries users for ambivalent emotions that evoke constructive criticism, in order to facilitate a discourse that favors the continuous innovation of a SaaS system. We discuss theoretical and practical implications of our approach for the study of user engagement in testing SaaS applications

Advances in gastric cancer prevention.

2noGastric cancer is a multifactorial neoplastic pathology numbering among its causes both environmental and genetic predisposing factors. It is mainly diffused in South America and South-East Asia, where it shows the highest morbility percentages and it is relatively scarcely diffused in Western countries and North America. Although molecular mechanisms leading to gastric cancer development are only partially known, three main causes are well characterized: Helicobacter pylori (H. pylori) infection, diet rich in salted and/or smoked food and red meat, and epithelial cadherin (E-cadherin) mutations. Unhealthy diet and H. pylori infection are able to induce in stomach cancer cells genotypic and phenotypic transformation, but their effects may be crossed by a diet rich in vegetables and fresh fruits. Various authors have recently focused their attention on the importance of a well balanced diet, suggesting a necessary dietary education starting from childhood. A constant surveillance will be necessary in people carrying E-cadherin mutations, since they are highly prone in developing gastric cancer, also within the inner stomach layers. Above all in the United States, several carriers decided to undergo a gastrectomy, preferring changing their lifestyle than living with the awareness of the development of a possible gastric cancer. This kind of choice is strictly personal, hence a decision cannot be suggested within the clinical management. Here we summarize the key points of gastric cancer prevention analyzing possible strategies referred to the different predisposing factors. We will discuss about the effects of diet, H. pylori infection and E-cadherin mutations and how each of them can be handled.openopenGiordano A; Cito L.Giordano, Antonio; Cito, L

Age-Related Reference Intervals of the Main Biochemical and Hematological Parameters in C57BL/6J, 129SV/EV and C3H/HeJ Mouse Strains

BACKGROUND: Although the mouse is the animal model most widely used to study the pathogenesis and treatment of human diseases, reference values for biochemical parameters are scanty or lacking for the most frequently used strains. We therefore evaluated these parameters in the C57BL/6J, 129SV/EV and C3H/HeJ mice. METHODOLOGY/PRINCIPAL FINDINGS: We measured by dry chemistry 26 analytes relative to electrolyte balance, lipoprotein metabolism, and muscle/heart, liver, kidney and pancreas functions, and by automated blood counter 5 hematological parameters in 30 animals (15 male and 15 female) of each mouse strain at three age ranges: 1-2 months, 3-8 months and 9-12 months. Whole blood was collected from the retro-orbital sinus. We used quality control procedures to investigate analytical imprecision and inaccuracy. Reference values were calculated by non parametric methods (median and 2.5(th) and 97.5(th) percentiles). The Mann-Whitney and Kruskal-Wallis tests were used for between-group comparisons. Median levels of GLU, LDH, Chol and BUN were higher, and LPS, AST, ALP and CHE were lower in males than in females (p range: 0.05-0.001). Inter-strain differences were observed for: (1) GLU, t-Bil, K+, Ca++, PO(4)- (p<0.05) and for TAG, Chol, AST, Fe++ (p<0.001) in 4-8 month-old animals; (2) for CK, Crea, Mg++, Na++, K+, Cl- (p<0.05) and BUN (p<0.001) in 2- and in 10-12 month-old mice; and (3) for WBC, RBC, HGB, HCT and PLT (p<0.05) during the 1 year life span. CONCLUSION/SIGNIFICANCE: Our results indicate that metabolic variations in C57BL/6J, 129SV/EV and C3H/HeJ mice after therapeutic intervention should be evaluated against gender- and age-dependent reference intervals

The Making of Cloud Applications An Empirical Study on Software Development for the Cloud

Cloud computing is gaining more and more traction as a deployment and provisioning model for software. While a large body of research already covers how to optimally operate a cloud system, we still lack insights into how professional software engineers actually use clouds, and how the cloud impacts development practices. This paper reports on the first systematic study on how software developers build applications in the cloud. We conducted a mixed-method study, consisting of qualitative interviews of 25 professional developers and a quantitative survey with 294 responses. Our results show that adopting the cloud has a profound impact throughout the software development process, as well as on how developers utilize tools and data in their daily work. Among other things, we found that (1) developers need better means to anticipate runtime problems and rigorously define metrics for improved fault localization and (2) the cloud offers an abundance of operational data, however, developers still often rely on their experience and intuition rather than utilizing metrics. From our findings, we extracted a set of guidelines for cloud development and identified challenges for researchers and tool vendors

The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: a pilot study

Objective: To assess the efficacy and safety of an association of diallyl thiosulfinate with nuciferine and diosgenin in the treatment of a group of patients suffering from premature ejaculation (PE), primary or secondary to erectile dysfunction (ED). Materials and methods: From July 2015 to October 2016, 143 patients (mean age 25.3; range 18-39) affected by PE completed the study and were finally analyzed in this phase I study. All patients, after clinical assessment and laboratory evaluation were asked to take an association of diallyl thiosulfinate with nuciferine and diosgenin as oral tablet, once a day, on alternate days, for three months. At the baseline and after three months of treatment, each patient was asked to complete the following questionnaires: International Index of Erectile Function (IIEF-5), Premature Ejaculation Diagnostic Tool (PEDT), Male Sexual Health Questionnaire (MSHQ). Results: A statistical significant improvement in terms of erectile function, comparing the IIEF-5 value at baseline and follow-up visit was found (respectively IIEF-5: 8.7 vs 14.01; p &lt; 0.001). Moreover, at follow-up visit, 97/143 men (67.8%) referred a subjective improvement of the erection quality and a better control of the ejaculation (PROs). The IELT improved too between the baseline evaluation and the follow-up visit (p &lt; 0.001). Conclusion: In conclusion, our study, even if supported by preliminary results, showed how Diallyl Thiosulfinate, Nuciferine and Diosgenin is able to improve the control of ejaculation in patients suffering from PE, primary or secondary to ED without any significant adverse effects

Электронная модель процесса движения частиц в тракте инжекции циклических ускорителей

In this work, under fully controlled flow conditions, we perform an in vitro verification of computational fluid dynamic (CFD) simulations against the experimental data of a stented aneurysm phantom. The stent model is simplified to have different sizes and its influence on the hemodynamic parameters is demonstrated. For CFD validation, quantitative measures are defined for CFD by virtual angiography. The results show general good correspondence in the parent vessel and the impingement site inside the aneurysm. Compared to the experimentally acquired angiograms, slight delay of the bolus arrival time is detected in the aneurysm sac in the virtual angiograms. This is correlated with over estimated stent function in the CFD model.</p

Numerical and experimental study of flow and wall mass transfer rates in capillary driven flows in microfluidic channels

Micro-channels are believed to open up the prospect of precise control of fluid flow and chemical reactions. The capillary effect can be used to pump fluids in micro-channels and the flow generated can dissolve chemicals previously deposited on the walls of the channel. In this work, numerical and experimental approaches have been developed to investigate the wall mass transfer rate generated by capillary driven flows (CD-Flow). The purpose of this work is to analyze the wall mass transfer rates generated by a CD-Flow in a micro-channel. The results have implications in the optimization and design of devices for biological assays. The correlation for Sherwood number, Reynolds number, contact angle and time is reported. This correlation can be a useful tool for design purposes of microfluidic devices that work with fast heterogeneous reaction and have capillary driven flow as passive pumping system. The numerical results have been confirmed by the experimental results.La perspectiva del uso de micro-canales para el control preciso del flujo y de las reacciones químicas está ampliamente aceptada. Considerando que el efecto de las tensiones superficiales en la micro-escala es significativo, el bombeo pasivo basado en el uso de la tensión superficial para los Lab-on-a-chip resulta ser el método más eficaz.El propósito de este trabajo es analizar la transferencia de masa en la pared en un campo dinámico de un flujo impulsado por capilaridad. Los resultados permitirán mejorar el diseño y optimizar los dispositivos para ensayos biológicos. Se presenta una correlación entre el número de Sherwood, el número de Reynolds, el ángulo de contacto y el tiempo. La correlación puede ser una herramienta útil en el diseño de dispositivos microfluídicos que trabajen con una reacción rápida y heterogénea y usen el bombeo pasivo impulsado por el flujo capilar. Los resultados numéricos han sido confirmados por los resultados experimentales