26 research outputs found
Rights Over Natural Resources: the Indonesian Experience
The coassembly of well-defined biological nanostructures relies on a delicate balance between attractive and repulsive interactions between biomolecular building blocks. Viral capsids are a prototypical example, where coat proteins exhibit not only self-interactions but also interact with the cargo they encapsulate. In nature, the balance between antagonistic and synergistic interactions has evolved to avoid kinetic trapping and polymorphism. To date, it has remained a major challenge to experimentally disentangle the complex kinetic reaction pathways that underlie successful coassembly of biomolecular building blocks in a noninvasive approach with high temporal resolution. Here we show how macromolecular force sensors, acting as a genome proxy, allow us to probe the pathways through which a viromimetic protein forms capsids. We uncover the complex multistage process of capsid assembly, which involves recruitment and complexation, followed by allosteric growth of the proteinaceous coat. Under certain conditions, the single-genome particles condense into capsids containing multiple copies of the template. Finally, we derive a theoretical model that quantitatively describes the kinetics of recruitment and growth. These results shed new light on the origins of the pathway complexity in biomolecular coassembly
Optical biometry of the anterior segment of the eye: Clinical applications
[No abstract available
Analysis of the pterygium size inducing marked refractive astigmatism
PURPOSE. Astigmatic changes induced by the pterygium and their relation to its size and morphology were analysed to establish the critical size for surgery before significant astigmatism occurs
Preserved human amniotic membrane transplantation in the treatment of primary pterygium
BACKGROUND AND OBJECTIVE: To assess the outcome of simple excision with preserved human amniotic membrane transplantation in the treatment of primary pterygium
IMPROVING ESTIMATION OF CORNEAL REFRACTIVE POWER BY MEASURING THE POSTERIOR CURVATURE OF THE CORNEA
We developed a formula to measure the posterior curvature of the cornea. In our study, real corneal power in 51 eyes was calculated by using anterior and posterior curvatures and corneal thickness. The corneal refractive index was found to be a variable value between 1.3243 and 1.3339 (mean 1.3304 +/- 0.0003)
Surgical management of postoperative endophthalmitis: Comparison of 2 techniques
Purpose. To evaluate the results of 2 surgical techniques in eyes with postoperative endophthalmitis
Management of free floating iris cysts in the anterior chamber: A case report
PURPOSE. To present a case with free iris cysts in the anterior chamber and its management with YAG laser
Indocyanine green angiography in Bietti's crystalline retinopathy
Background: To our knowledge, the indocyanine green (ICG) angiographic features of Bietti's crystalline retinopathy have been described in a single case only. We report the ICG angiographic findings in four patients with Bietti's crystalline retinopathy and compare them with the fluorescein angiographic findings
Transscleral fixation of foldable intraocular lenses.
Purpose: To report the results of transscleral implantation of foldable intraocular lenses (IOLs)