469 research outputs found
Effect of a gonadotrophin-releasing hormone analogue on lung function in lymphangioleiomyomatosis
Background: Lymphangioleiomyomatosis (LAM), a multisystem disease occurring primarily in women, is characterized by cystic lung destruction, and kidney and lymphatic tumors, caused by the proliferation of abnormal-appearing cells (ie, LAM cells) with a smooth muscle cell phenotype that express melanoma antigens and are capable of metastasizing. Estrogen receptors are present in LAM cells, and this finding, along with reports of disease progression during pregnancy or following exogenous estrogen administration, suggest the involvement of estrogens in the pathogenesis of LAM. Consequentiy, antiestrogen therapies have been employed in treatment. The goal of this prospective study was to evaluate the efficacy of triptorelin, a gonadotrophin-releasing hormone analogue, in 11 premenopausal women with LAM. Methods: Patients were evaluated at baseline and every 3 to 6 months thereafter, for a total of 36 months. Hormonal assays, pulmonary function tests, 6-min walk tests, high-resolution CT scans of the chest, and bone mineral density studies were performed. Results: Gonadal suppression was achieved in all patients. Overall, a significant decline in lung function was observed; two patients underwent lung transplantation 1 year after study enrollment, and another patient was lost to follow-up. Treatment with triptorelin was associated with a decline in bone mineral density. Conclusions: Triptorelin appears not to prevent a decline in lung function in patients with LAM. Its use, however, may be associated with the loss of bone mineral density
Prognosis and determinants of serum PTH changes over time in 1-5 CKD stage patients followed in tertiary care
International Guidelines for mineral bone disorders recommend that in Non Dialytic-Chronic Kidney Disease (ND-CKD) clinical decisions should be based on the trend of serum PTH changes over time rather than on a single value. However, the prognostic impact of these changes in ND-CKD patients remains unknown. We performed a multicenter cohort study in ND-CKD patients (stage 1-5) followed for 36 months in 24 Italian Nephrology Units. PTH changes (\u394PTH) were defined as the absolute differences between all available PTH measurements following the first control and basal value. Primary endpoint in this subanalysis was renal death (End-Stage Renal Disease (ESRD) or all-causes death before ESRD). Association between renal death and \u394PTH was assessed by time-dependent Cox model for repeated measurements. Out of the original cohort (N = 884), we selected 543 patients (66.3\ub115.4 ys, 58.4% males) with at least two serum PTH measurements. At baseline, eGFR was 36 (IQR: 22.4-56.8) mL/min/1.73m2 and serum PTH 46 (IQR: 28-81) pg/mL. \u394PTH was in median 0 (IQR:-18/18) pg/mL. Basal predictors of longitudinal PTH increments were higher serum phosphate, more advanced CKD stages and lower serum PTH. Fully adjusted Cox model with \u394PTH quartiles as discrete time-dependent covariate showed a significant risk of renal death in the highest quartile (HR: 1.91; 95%CI:1.08-3.38; P = 0.026). Considering \u394PTH, as continuous time-dependent variable, (HR:1.02; 95%C.I.: 1.01-1.04; P = 0.004), risk of renal death progressively rose as \u394PTH increased. An increment in serum PTH over time is associated with a worse prognosis in ND-CKD patients, independently from baseline or any absolute concentration of serum PTH and phosphate
Measurement of the D+ and Ds+ decays into K+K-K+
We present the first clear observation of the doubly Cabibbo suppressed decay
D+ --> K-K+K+ and the first observation of the singly Cabibbo suppressed decay
Ds+ --> K-K+K+. These signals have been obtained by analyzing the high
statistics sample of photoproduced charm particles of the FOCUS(E831)
experiment at Fermilab. We measure the following relative branching ratios:
Gamma(D+ --> K-K+K+)/Gamma(D+ --> K-pi+pi+) = (9.49 +/- 2.17(statistical) +/-
0.22(systematic))x10^-4 and Gamma(Ds+ --> K-K+K+)/Gamma(Ds+ --> K-K+pi+) =
(8.95 +/- 2.12(statistical) +2.24(syst.) -2.31(syst.))x10^-3.Comment: 10 pages, 8 figure
A Non-parametric Approach to the D+ to K*0bar mu+ nu Form Factors
Using a large sample of D+ -> K- pi+ mu+ nu decays collected by the FOCUS
photoproduction experiment at Fermilab, we present the first measurements of
the helicity basis form factors free from the assumption of spectroscopic pole
dominance. We also present the first information on the form factor that
controls the s-wave interference discussed in a previous paper by the FOCUS
collaboration. We find reasonable agreement with the usual assumption of
spectroscopic pole dominance and measured form factor ratios.Comment: 14 pages, 5 figures, and 2 tables. We updated the previous version by
changing some words, removing one plot, and adding two tables. These changes
are mostly stylisti
Search for and Using Genetic Programming Event Selection
We apply a genetic programming technique to search for the double Cabibbo
suppressed decays and .
We normalize these decays to their Cabibbo favored partners and find
\Lambda_c^+ \to p K^+ \pi^-\Lambda_c^+ \to p K^-
\pi^+ and D_s^+ \to K^+ K^+
\pi^-D_s^+ \to K^+ K^- \pi^+ where
the first errors are statistical and the second are systematic. Expressed as
90% confidence levels (CL), we find and respectively.
This is the first successful use of genetic programming in a high energy
physics data analysis.Comment: 10 page
Study of Hadronic Five-Body Decays of Charmed Mesons
We study the decay of D+ and Ds+ mesons into charged five body final states,
and report the discovery of the decay mode D+ -> K+K-Pi+Pi+Pi-, as well as
measurements of the decay modes D+ -> K-Pi+Pi+Pi+Pi-, Ds+ -> K+K-Pi+Pi+Pi-, Ds+
-> PhiPi+Pi+Pi- and D+/Ds+ -> Pi+Pi+Pi+Pi-Pi-. An analysis of the resonant
substructure is also included, with evidence suggesting that both decays
proceed primarily through an a1 vector resonance.Comment: 11 pages, 3 figure
Measurements of Branching Ratios
Using data collected by the fixed target Fermilab experiment FOCUS, we
measure the branching ratios of the Cabibbo favored decays , , and relative to to be
, , and ,
respectively. We report the first observation of the Cabibbo suppressed decay
and we measure the branching ratio relative to
to be . We also set 90%
confidence level upper limits for and relative to to
be 0.12 and 0.05, respectively. We find an indication of the decays and and set
90% confidence level upper limits for the branching ratios with respect to
to be 0.12 and 1.72, respectively. Finally, we
determine the 90% C.L. upper limit for the resonant contribution relative to to be 0.10.Comment: 14 pages, 8 figure
New Measurements of the D+ to K* mu nu Form Factor Ratios
Using a large sample of D+ to K- pi+ mu+ nu decays collected by the FOCUS
photoproduction experiment at Fermilab, we present new measurements of two
semileptonic form factor ratios: rv and r2. We find rv = 1.504 \pm 0.057 \pm
0.039 and r2 = 0.875 \pm 0.049 \pm 0.064. Our form factor results include the
effects of the s-wave interference discussed in a previous paper.Comment: 12 pages, 5 figure
Study of the D^0 \to pi^-pi^+pi^-pi^+ decay
Using data from the FOCUS (E831) experiment at Fermilab, we present new
measurements for the Cabibbo-suppressed decay mode . We measure the branching ratio .
An amplitude analysis has been performed, a first for this channel, in order to
determine the resonant substructure of this decay mode. The dominant component
is the decay , accounting for 60% of the decay rate.
The second most dominant contribution comes from the decay , with a fraction of 25%. We also study the
line shape and resonant substructure. Using the helicity formalism for the
angular distribution of the decay , we measure
a longitudinal polarization of %.Comment: 38 pages, 8 figures. accepted for publication in Physical Review
Dalitz plot analysis of D_s+ and D+ decay to pi+pi-pi+ using the K-matrix formalism
FOCUS results from Dalitz plot analysis of D_s+ and D+ to pi+pi-pi+ are
presented. The K-matrix formalism is applied to charm decays for the first time
to fully exploit the already existing knowledge coming from the light-meson
spectroscopy experiments. In particular all the measured dynamics of the S-wave
pipi scattering, characterized by broad/overlapping resonances and large
non-resonant background, can be properly included. This paper studies the
extent to which the K-matrix approach is able to reproduce the observed Dalitz
plot and thus help us to understand the underlying dynamics. The results are
discussed, along with their possible implications on the controversial nature
of the sigma meson.Comment: To be submitted to Phys.Lett.B A misprint corrected in formula
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