13 research outputs found
A respeito da materialidade do patrimônio imaterial: o caso do INRC Porongos
O colecionamento e a conservação de "bens culturais" vêm ganhando em complexidade pela inclusão de temas oriundos de minorias étnicas e econômicas. Apesar do consenso relativo ao conceito de patrimônio cultural proposto pela Unesco, a definição do que deve ser preservado e celebrado como "bem cultural" pode ser objeto de lutas polÃticas, jurÃdicas, econômicas e sociais. Visando refletir sobre as consequências dessas lutas, este artigo aborda o processo de inventário de referências culturais em torno do Massacre de Porongos, evento da Revolução Farroupilha (1835-1845) que vem servindo de apoio à configuração de uma identidade negra e gaúcha no Rio Grande do Sul. Segundo os autores, apesar de se apresentar no registro de "patrimônio imaterial", o processo de inventário possibilitou a fabricação de um "corpo" (de textos e imagens) e a delimitação de "lugares" (de memória) a partir dos quais os referentes culturais ditos "imateriais" vêm se inscrever.<br>The collection and conservation of "cultural objects" has been gaining in complexity with the inclusion of non-material associations regarding ethnic and economic minorities. Despite the consensus on the concept of cultural heritage proposed by Unesco, the definition of what should be preserved and celebrated as "cultural object" may be subject of political, legal, economic and social struggles. In order to reflect upon the consequences of these struggles, this article discusses the process of inventory of cultural references related to the Porongos Massacre, an event of the Farroupilha's Revolution (1835-1845). These cultural references are serving in the configuration of black people's and gauchos identities. According to the authors, althought relating to the "intangible heritage", the process of inventory has enabled the fabrication of a "body" (text and images) and the definition of "places" (from memory) from which the cultural references so-called "non-material" come subscribe
Calibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
Serum creatinine (SCr) is the main variable for
estimating glomerular filtration rate (GFR). Due to interassay
differences, the prevalence of chronic kidney disease
(CKD) varies according to the assay used, and calibration
standardization is necessary. For SCr, isotope dilution
mass spectrometry (IDMS) is the gold standard. Systematic
differences are observed between Jaffe and enzymatic
methods. Manufacturers subtract 0.30 mg/dl from Jaffe
results to match enzymatic results (‘compensated Jaffe
method’). The analytical performance of enzymatic
methods is superior to that of Jaffe methods. In the original
Modification of Diet in Renal Disease (MDRD) equation,
SCr was measured by a Jaffe Beckman assay, which was
later recalibrated. A limitation of this equation was an
underestimation of GFR in the high range. The Chronic
Kidney Disease Epidemiology (CKD-EPI) consortium
proposed an equation using calibrated and IDMS traceable
SCr. The gain in performance was due to improving the
bias whereas the precision was comparable. The CKD-EPI
equation performs better at high GFR levels (GFR[60 ml/
min/1.73 m2). Analytical limitations have led to the recommendation
to give a grade ([60 ml/min/1.73 m2) rather
than an absolute value with the MDRD equation. By using
both enzymatic and calibrated methods, this cutoff-grade
could be increased to 90 ml/min/1.73 m2 (with MDRD)
and 120 ml/min/1.73 m2 (with CKD-EPI). The superiority
of the CKD-EPI equation over MDRD is analytical, but
the precision gain is limited. IDMS traceable enzymatic
methods have been used in the development of the Lund–
Malmo¨ (in CKD populations) and Berlin Initiative Study
equations (in the elderly). The analytical errors for cystatin
C are grossly comparable to issues found with SCr.
Standardization is available since 2011. A reference
method for cystatin C is still lacking. Equations based on
standardized cystatin C or cystatin C and creatinine have
been proposed. The better performance of these equations
(especially the combined CKD-EPI equation) has been
demonstrated