Metallicity variations in the Type II globular cluster NGC6934

The Hubble Space Telescope photometric survey of Galactic globular clusters (GCs) has revealed a peculiar "chromosome map" for NGC6934. Besides a typical sequence, similar to that observed in Type I GCs, NGC 6934 displays additional stars on the red side, analogous to the anomalous, Type II GCs, as defined in our previous work. We present a chemical abundance analysis of four red giants in this GC. Two stars are located on the chromosome map sequence common to all GCs, and another two on the additional sequence. We find: (i) star-to-star Fe variations, with the two anomalous stars being enriched by ~0.2 dex. Due to our small-size sample, this difference is at the ~2.5 sigma level; (ii) no evidence for variations in the slow neutron-capture abundances over Fe, at odds with what is often observed in anomalous Type II GCs, e.g. M 22 and Omega Centauri; (iii) no large variations in light elements C, O and Na, compatible with the targets location on the lower part of the chromosome map where such variations are not expected. Since the analyzed stars are homogeneous in light elements, the only way to reproduce the photometric splits on the sub-giant (SGB) and the red-giant (RGB) branches is to assume that red-RGB/faint-SGB stars are enhanced in [Fe/H] by ~0.2. This fact corroborates the spectroscopic evidence of a metallicity variation in NGC6934. The observed chemical pattern resembles only partially the other Type II GCs, suggesting that NGC6934 might belong either to a third class of GCs, or be a link between normal Type I and anomalous Type II GCs.Comment: 26 pages, 9 figures, accepted for publication in Ap

mRNA Display Selection of an Optimized MDM2-Binding Peptide That Potently Inhibits MDM2-p53 Interaction

p53 is a tumor suppressor protein that prevents tumorigenesis through cell cycle arrest or apoptosis of cells in response to cellular stress such as DNA damage. Because the oncoprotein MDM2 interacts with p53 and inhibits its activity, MDM2-p53 interaction has been a major target for the development of anticancer drugs. While previous studies have used phage display to identify peptides (such as DI) that inhibit the MDM2-p53 interaction, these peptides were not sufficiently optimized because the size of the phage-displayed random peptide libraries did not cover all of the possible sequences. In this study, we performed selection of MDM2-binding peptides from large random peptide libraries in two stages using mRNA display. We identified an optimal peptide named MIP that inhibited the MDM2-p53 and MDMX-p53 interactions 29- and 13-fold more effectively than DI, respectively. Expression of MIP fused to the thioredoxin scaffold protein in living cells by adenovirus caused stabilization of p53 through its interaction with MDM2, resulting in activation of the p53 pathway. Furthermore, expression of MIP also inhibited tumor cell proliferation in a p53-dependent manner more potently than DI. These results show that two-stage, mRNA-displayed peptide selection is useful for the rapid identification of potent peptides that target oncoproteins

A massive helium star with a sufficiently strong magnetic field to form a magnetar

Magnetars are highly magnetized neutron stars; their formation mechanism is unknown. Hot helium-rich stars with spectra dominated by emission lines are known as Wolf-Rayet stars. We observe the binary system HD 45166 using spectropolarimetry, finding that it contains a Wolf-Rayet star with a mass of 2 solar masses and a magnetic field of 43 kilogauss. Stellar evolution calculations indicate that this component will explode as a type Ib or IIb supernova, and the strong magnetic field favors a magnetar remnant. We propose that the magnatized Wolf-Rayet star formed by the merger of two lower mass helium stars.Comment: Published in Science on the 18 August 2023. Radial velocities, spectra, and software available in: https://zenodo.org/record/8042656 ESO press release: www.eso.org/public/news/eso231

CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE.

BACKGROUND: Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load. METHODS AND FINDINGS: Using data from the Collaboration of Observational HIV Epidemiological Research Europe (2010 merger), we assessed the risk of a new AIDS-defining event or death in successfully treated patients. We accumulated episodes of viral suppression for each patient while on cART, each episode beginning with the second of two consecutive plasma viral load measurements 500 copies/µl, the first of two consecutive measurements between 50-500 copies/µl, cART interruption or administrative censoring. We used stratified multivariate Cox models to estimate the association between time updated CD4 cell count and a new AIDS event or death or death alone. 75,336 patients contributed 104,265 suppression episodes and were suppressed while on cART for a median 2.7 years. The mortality rate was 4.8 per 1,000 years of viral suppression. A higher CD4 cell count was always associated with a reduced risk of a new AIDS event or death; with a hazard ratio per 100 cells/µl (95% CI) of: 0.35 (0.30-0.40) for counts <200 cells/µl, 0.81 (0.71-0.92) for counts 200 to <350 cells/µl, 0.74 (0.66-0.83) for counts 350 to <500 cells/µl, and 0.96 (0.92-0.99) for counts ≥500 cells/µl. A higher CD4 cell count became even more beneficial over time for patients with CD4 cell counts <200 cells/µl. CONCLUSIONS: Despite the low mortality rate, the risk of a new AIDS event or death follows a CD4 cell count gradient in patients with viral suppression. A higher CD4 cell count was associated with the greatest benefit for patients with a CD4 cell count <200 cells/µl but still some slight benefit for those with a CD4 cell count ≥500 cells/µl

MOST light-curve analysis of the γ Doradus pulsator HR 8799, showing resonances and amplitude variations

Context. The central star of the HR 8799 system is a γ Doradus-type pulsator. The system harbours four planetary-mass companions detected by direct imaging, and is a good solar system analogue. The masses of the companions are not accurately known because the estimation depends greatly on the age of the system, which is also not known with sufficient accuracy. Asteroseismic studies of the star might help to better constrain the age of HR 8799. We organized an extensive photometric and multi-site spectroscopic observing campaign to study the pulsations of the central star. Aims: The aim of the present study is to investigate the pulsation properties of HR 8799 in detail via the ultra-precise 47 d nearly continuous photometry obtained with the Microvariability and Oscillations in STars (MOST) space telescope, and to find as many independent pulsation modes as possible, which is the prerequisite for an asteroseismic age determination. Methods: We carried out Fourier analysis of the wide-band photometric time series. Results: We find that resonance and sudden amplitude changes characterize the pulsation of HR 8799. The dominant frequency is always at f1 = 1.978 d-1.Many multiples of one-ninth of the dominant frequency appear in the Fourier spectrum of the MOST data: n/9 f1, where n = {1,2,3,4,5,6,7,8,9,10,13,14,17,18}. Our analysis also reveals that many of these peaks show strong amplitude decrease and phase variations even on the 47 d time scale. The dependencies between the pulsation frequencies of HR 8799 make the planned subsequent asteroseismic analysis rather difficult. We point out some resemblance between the light curve of HR 8799 and the modulated pulsation light curves of Blazhko RR Lyrae stars. Based on data from the MOST satellite, a Canadian Space Agency mission, jointly operated by Dynacon Inc., the University of Toronto Institute for Aerospace Studies and the University of British Columbia, with the assistance of the University of Vienna

The Many Virtues of Second Nature : Habitus in Latin Medieval Philosophy

This chapter consists of a systematic introduction to the nature and function of habitus in Latin medieval philosophy. Over the course of this introduction, several topics are treated: the theoretical necessity to posit habitus; their nature; their causal contribution to the production of internal and external acts; how and why habitus can grow and decay; what makes their unity when they can have multiple objects and work in clusters. Finally we examine two specific questions: why intellectual habitus represent a special case that triggered considerable debate; how human beings can be said to be free if their actions are determined by moral habitus