Estimate of hourly productivity applied to elaboration and implementation of mining plans

In order to elaborate a mine plan, it is necessary to adopt hourly production parameters for the equipment available for its execution. This equipment should be in synchrony with the productive capacity of the operational units in the mine for: rock drilling, blasting, loading and transporting ore. This study deals with the estimate of hourly production indexes for loading and transport obtained by the use of multiple regressions. Using a management system database from an operating mine, equations were generated to explain the productive cycle of each of the loading machines and dump trucks. Knowing the behavior of the principle variables that exert influence on the production schedule, it was possible to estimate the index and to guarantee high feasibility for the mine plan, considering the indexes obtained were very close to those executed. The model design was created in a simple manner, using statistical concepts and computational tools, being supported by good correlation between the variables. This factor was decisive in obtaining good results in the execution of the studied mining plan

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.

Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption of transmembrane protein 176B (TMEM176B) contributes to CD8+ T cell-mediated tumor growth inhibition by unleashing inflammasome activation. Lack of Tmem176b enhances the antitumor activity of anti-CTLA-4 antibodies through mechanisms involving caspase-1/IL-1β activation. Accordingly, patients responding to checkpoint blockade therapies display an activated inflammasome signature. Finally, we identify BayK8644 as a potent TMEM176B inhibitor that promotes CD8+ T cell-mediated tumor control and reinforces the antitumor activity of both anti-CTLA-4 and anti-PD-1 antibodies. Thus, pharmacologic de-repression of the inflammasome by targeting TMEM176B may enhance the therapeutic efficacy of immune checkpoint blockers.Uruguay INNOVA 2, Fondo Maria Viñas and Clemente Estable from ANII, as well as grants from CABBIO, PEDECIBA, ECOS-SUD and FOCEM (MERCOSUR Structural Convergence Fund), COF 03/11 to MH, The Harry J Lloyd Foundation to MRG and the Instituto Nacional del Cancer to YDM, Agencia de Promoción Científica y Tecnológica to GAR and MRG, Fundación Bunge & Born and Fundación Sales to GA

Mortalidade por doenças cardiorrespiratórias em idosos no estado de Mato Grosso, 1986 a 2006

OBJETIVO: Descrever a evolução temporal da mortalidade por doenças cardiorrespiratórias em idosos. MÉTODOS: Estudo epidemiológico descritivo com delineamento ecológico de séries temporais realizado no estado do Mato Grosso, de 1986 a 2006. Foram utilizados dados sobre doenças dos aparelhos respiratório e circulatório obtidos do Sistema de Informação sobre Mortalidade do Ministério da Saúde. Modelos de regressão linear simples foram ajustados para avaliar a tendência das taxas específicas de mortalidade por grupos específicos de idade (60 a 69, 70 a 79 e 80 ou mais anos) e sexo. RESULTADOS: Houve aumento na proporção de óbitos por doenças respiratórias e diminuição por doenças cardiovasculares. Na comparação de taxas entre os sexos, as mulheres apresentaram taxas 15% menores para as causas cardiovasculares e taxas similares ao sexo masculino para as causas respiratórias. Foi observada taxa elevada de mortalidade por doenças respiratórias e cardiovasculares, com importante tendência de incremento entre os grupos mais longevos. Em idosos com idade >; 80 anos o aumento anual médio na taxa de mortalidade por doenças respiratórias foi de 1,99 óbitos e de 3,43 por doenças do aparelho circulatório. CONCLUSÕES: O estado de Mato Grosso apresenta elevada taxa de mortalidade por doenças respiratórias e cardiovasculares em idosos, com importante tendência de incremento entre os grupos mais longevos.OBJETIVO: Describir la evolución temporal de la mortalidad por enfermedades cardiorrespiratorias en ancianos. MÉTODOS: Estudio epidemiológico descriptivo con delineamiento ecológico de series temporales realizado en el Estado de Mato Grosso, Centro-Oeste de Brasil, de 1986 a 2006. Se utilizaron datos sobre enfermedades de los aparatos respiratorio y circulatorio obtenidos del Sistema de Información sobre Mortalidad del Ministerio de la Salud. Modelos de regresión lineal simple fueron ajustados para evaluar la tendencia de las tasas específicas de mortalidad por grupos específicos de edad (60 a 69, 70 a 70 y 80 o más años) y sexo. RESULTADOS: Hubo aumento en la proporción de óbitos por enfermedades respiratorias y disminución por enfermedades cardiovasculares. En la comparación de tasas entre los sexos, las mujeres presentaron tasas 15% menores para las causas cardiovasculares y tasas similares al sexo masculino para las causas respiratorias Se observó tasa elevada de mortalidad por enfermedades respiratorias y cardiovasculares, con importante tendencia de incremento entre los grupos más longevos. En ancianos con edad ³80 años o aumento anual promedio en la tasa de mortalidad por enfermedades respiratorias fue de 1,99 óbitos y de 3,43 por enfermedades del aparato circulatorio. CONCLUSIONES: El Estado de Mato Grosso presenta elevada tasa de mortalidad por enfermedades respiratorias y cardiovasculares en ancianos, con importante tendencia de incremento entre los grupos más longevos.OBJECTIVE: To describe time trends of mortality due to cardiorespiratory diseases in elderly people. METHODS: Epidemiological descriptive study with an ecological time series approach conducted in the state of Mato Grosso, Central-West Brazil, between 1986 and 2006. Data were obtained from the Brazilian Ministry of Health Mortality Database. Linear regression models were adjusted to analyze trends in mortality rates by age groups (60 to 69; 70 to 79; and 80 or more) and gender. RESULTS: There was an increase in proportion of deaths due to respiratory diseases and a decrease in proportion of deaths due to cardiovascular diseases. As for gender, cardiovascular rates were 15% lower in women than men and respiratory rates were similar in both men and women. High mortality rates for respiratory and cardiovascular diseases were observed with increasing trends among the oldest-old groups. The annual average increase for respiratory and cardiovascular diseases in those aged 80 years and older was 1.99 and 3.43 deaths, respectively. CONCLUSIONS: The state of Mato Grosso shows high mortality rates due to cardiorespiratory disease among elderly people with increasing trends among the oldest-old groups

DESIGN AND ANALYSIS OF PAIRED COMPARISON EXPERIMENTS INVOLVING MIXTURES

2019110

Statistical inference for damaged Poisson distribution

For non-negative integer-valued random variables, the concept of "damaged" observations was introduced, for the first time, by Rao and Rubin [Rao, C. R., Rubin, H. (1964). On a characterization of the Poisson distribution. Sankhya 26:295-298] in 1964 on a paper concerning the characterization of Poisson distribution. In 1965, Rao [Rao, C. R. (1965). On discrete distribution arising out of methods of ascertainment. Sankhya Ser. A. 27:311-324] discusses some results related with inferences for parameters of a Poisson Model when it has occurred partial destruction of observations. A random variable is said to be damaged if it is unobservable, due to a damage mechanism which randomly reduces its magnitude. In subsequent years, considerable attention has been given to characterizations of distributions of such random variables that satisfy the "Rao-Rubin" condition. This article presents some inference aspects of a damaged Poisson distribution, under reasonable assumption that, when an observation on the random variable is made, it is also possible to determine whether or not some damage has occurred. In other words, we do not know how many items are damaged, but we can identify the existence of damage. Particularly it is illustrated the situation in which it is possible to identify the occurrence of some damage although it is not possible to determine the amount of items damaged. Maximum likelihood estimators of the underlying parameters and their asymptotic covariance matrix are obtained. Convergence of the estimates of parameters to the asymptotic values are studied through Monte Carlo simulations.33225926

On some fractional Green's functions

In this paper we discuss some fractional Green's functions associated with the fractional differential equations which appear in several fields of science, more precisely, the so-called wave reaction-diffusion equation and some of its particular cases. The methodology presented is the juxtaposition of integral transforms, in particular, the Laplace and the Fourier integral transforms. Some recent results involving the reaction-diffusion equation are pointed out.50