Linking human-building interactions in shared offices with personality traits

Occupant behavior influences office building energy performance. The level of human-building interactions (HBIs) in shared offices strongly influences building energy use and occupant well-being. This study explored the link between occupant personality types and their behaviors of sharing energy and environment control systems and interactions with their colleagues. Inspired by the Five-Factor Model (FFM), we classified HBI behaviors into four dimensions: willingness to share control, knowledge of control, group decision behavior, and adaptive strategies. These four variables can be mapped to the four personality traits proposed by the FFM: agreeableness, openness, extraversion, and conscientiousness. Our cluster analysis identified six behavioral patterns: average (17.7%), reserved (15.3%), environmentally friendly (16.6%), role model (24.2%), self-centered (17.2%), and mechanist (9.0%). We further applied association rules, a widely utilized machine learning technique, to discover how demographics, building-related contextual factors, and perception-attitudinal factors influence HBI behaviors. Country, control feature accessibility, and group dynamics were found to be the three most influential factors that determine occupants’ HBI behaviors. The study provides insights about building design and operation, as well as policy to promote socially and environmentally desirable HBI behaviors in a shared office environment

Investigating freeway traffic hypercongestion between an on-ramp and its immediate upstream off-ramp

This paper applies the freeway traffic congestion dynamics proposed in Laval and Leclercq [2010. “Continuum Approximation for Congestion Dynamics Along Freeway Corridors.” Transportation Science 44 (1): 87–97] but with a modified distribution scheme of freeway merging flows to investigation of traffic hypercongestion on a freeway between an on-ramp and its immediate upstream off-ramp. The reason to make this modification is that the original merging scheme of this dynamics is found to possibly give undesired full priority to the traffic from the on-ramp and also occasionally make the resulting flow going through the merge greater than the available capacity. Traffic hypercongestion in this paper refers to a state where speed and flow change in the same direction as density varies. A homogeneous freeway segment chosen for this investigation includes an on-ramp and an off-ramp, which may correspond to a freeway passing by a city or town, with an off-ramp lying upstream towards the city and an on-ramp downstream. The entry flow from the upstream approach of the freeway was fixed and constant within the time horizon while both deterministic and random on-ramp inflow rates were used in this investigation. Then the formation and dissipation of traffic hypercongestion is investigated as on-ramp demand and off-ramp departure profiles vary. The first finding of this investigation is that the density in the hypercongestion area behind the merge never reached the jam density. Second, the hypercongested area continued to grow as long as the sum of the demand from the upstream of the freeway and that from the on-ramp was greater than the available capacity at the merge. Third, as long as the rate of flow leaving from the freeway via the off-ramp was not smaller than the entry flow rates from the on-ramp, no hypercongestion had been observed. In addition, in analysing the numerical results, a series of discussions was carried out to build the linkage between the on- and off-ramp flow profiles and the generated and attracted demand of the city plus its adjacent area the two ramps served for; these discussions suggest that the balanced generated and attracted demand of the city plus its adjacent area can reduce or even remove traffic hypercongestion behind the merge on the chosen freeway segment.postprin

The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity

<p>Abstract</p> <p>Background</p> <p>Macrophage infiltration in adipose tissue together with the aberrant production of pro-inflammatory cytokines has been identified as the key link between obesity and its related metabolic disorders. This study aims to isolate bioactive ingredients from the traditional Chinese herb Radix Astragali (Huangqi) that alleviate obesity-induced metabolic damage through inhibiting inflammation.</p> <p>Methods</p> <p>Active fraction (Rx) that inhibits pro-inflammatory cytokine production was identified from Radix Astragali by repeated bioactivity-guided high-throughput screening. Major constituents in Rx were identified by column chromatography followed by high-performance liquid chromatography (HPLC) and mass-spectrometry. Anti-diabetic activity of Rx was evaluated in db/db mice.</p> <p>Results</p> <p>Treatment with Rx, which included calycosin-7-β-D-glucoside (0.9%), ononin (1.2%), calycosin (4.53%) and formononetin (1.1%), significantly reduced the secretion of pro-inflammatory cytokines (TNF-α, IL-6 and MCP-1) in human THP-1 macrophages and lipopolysaccharide (LPS)-induced activation of NF-κB in mouse RAW-Blue macrophages in a dose-dependent manner. Chronic administration of Rx in db/db obese mice markedly decreased the levels of both fed and fasting glucose, reduced serum triglyceride, and also alleviated insulin resistance and glucose intolerance when compared to vehicle-treated controls. The mRNA expression levels of inflammatory cell markers CD68 and F4/80, and cytokines MCP-1, TNF-α and IL-6 were significantly reduced in epididymal adipose tissue while the alternatively activated macrophage marker arginase I was markedly increased in the Rx-treated mice.</p> <p>Conclusion</p> <p>These findings suggest that suppression of the inflammation pathways in macrophages represents a valid strategy for high-throughput screening of lead compounds with anti-diabetic and insulin sensitizing properties, and further support the etiological role of inflammation in the pathogenesis of obesity-related metabolic disorders.</p

Uncoupling Protein-2 Mediates DPP-4 Inhibitor-Induced Restoration of Endothelial Function in Hypertension Through Reducing Oxidative Stress

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p38 Mapk signal pathway involved in anti-inflammatory effect of chaihu-shugan-san and shen-ling-bai-zhu-san on hepatocyte in non-alcoholic steatohepatitis rats

Background: Traditional Chinese Medicine (TCM), has over thousands-of-years history of use. Chaihu-Shugan-San (CSS), and Shen-ling-bai-zhu-San (SLBZS), are famous traditional Chinese herbal medicine formulas, which have been used in China, for the treatment of many chronic diseases.Materials and Methods:This study investigated the anti-inflammatory effects of CSS and SLBZS on signaling molecules involved in p38 mitogen-activated protein kinase (p38 MAPK), pathway on hepatocytes of non-alcoholic steatohepatitis (NASH), rats induced by high fat diet. SD male rats were randomly divided into 8 groups: negative control group, model control group, high (9.6g/kg/day)/low (3.2g/kg/day)-dose CSS group, high (30g/kg/day)/low (10g/kg/day)-dose SLBZS group, high (39.6g/kg/day)/low (13.2g/kg/day)-dose integrated group. The rats of NASH model were induced by feeding a high-fat diet. After 16, wks, Hepatocytes were isolated from 6, rats in each group by collagenase perfusion. The liver histopathological changes and serum inflammatory cytokines TNF-α, IL-6 were determined. The proteins of TLR4,  phosphor-p38 MAPK and p38 MAPK involved in p38 MAPK signal pathway were assayed.Results: The statistical data indicated the NASH model rats reproduced typical histopathological features of NASH in human. CSS and SLBZS ameliorated lipid metabolic disturbance, attenuated NASH progression, decreased the levels of TNF-α and IL-6 in serum, as well as inhibited TLR4 protein expression, p38 MAPK phosphorylation, and activation of p38 MAPK. In conclusion, CSS and SLBZS might work as a significant anti-inflammatory effect on hepatocyte of NASH by inhibiting the activation of TLR4, p-p38 MAPK and p38 MAPK involved in p38 MAPK signal pathway.Conclusion: To some extent, CSS and SLBZS may be a potential alternative and complementary medicine to protect against liver injury, alleviate the inflammation reaction, moderate NASH progression.Key words: p38 mitogen-activated protein kinase; Toll like receptor 4; Hepatocytes; Non-alcoholic Steatohepatitis; Traditional Chinese medicine

Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice

The mechanisms underlying the effect of the renin-angiotensin-aldosterone system (RAAS) inhibition on endothelial dysfunction in type 2 diabetes are incompletely understood. This study explored a causal relationship between RAAS activation and oxidative stress involved in diabetes-associated endothelial dysfunction. Daily oral administration of valsartan or enalapril at 10mg/kg/day to db/db mice for 6 weeks reversed the blunted acetylcholine-induced endothelium-dependent dilatations, suppressed the upregulated expression of angiotensin II type 1 receptor (AT1R) and NAD(P)H oxidase subunits (p22phox and p47phox), and reduced reactive oxygen species (ROS) production. Acute exposure to AT1R blocker losartan restored the impaired endothelium-dependent dilatations in aortas of db/db mice and also in renal arteries of diabetic patients (fasting plasma glucose level ≥7.0 mmol/l). Similar observations were also made with apocynin, diphenyliodonium, or tempol treatment in db/db mouse aortas. DHE fluorescence revealed an overproduction of ROS in db/db aortas which was sensitive to inhibition by losartan or ROS scavengers. Losartan also prevented the impairment of endothelium-dependent dilatations under hyperglycemic conditions that were accompanied by high ROS production. The present study has identified an initiative role of AT1R activation in mediating endothelial dysfunction of arteries from db/db mice and diabetic patients. © 2010 Mary Ann Liebert, Inc.published_or_final_versio

Electro-optically tunable microring resonators in lithium niobate

Optical microresonators have recently attracted a growing attention in the photonics community. Their applications range from quantum electro-dynamics to sensors and filtering devices for optical telecommunication systems, where they are likely to become an essential building block. The integration of nonlinear and electro-optical properties in the resonators represents a very stimulating challenge, as it would incorporate new and more advanced functionality. Lithium niobate is an excellent candidate material, being an established choice for electro-optic and nonlinear optical applications. Here we report on the first realization of optical microring resonators in submicrometric thin films of lithium niobate. The high index contrast films are produced by an improved crystal ion slicing and bonding technique using benzocyclobutene. The rings have radius R=100 um and their transmission spectrum has been tuned using the electro-optic effect. These results open new perspectives for the use of lithium niobate in chip-scale integrated optical devices and nonlinear optical microcavities.Comment: 15 pages, 8 figure

Endoplasmic reticulum chaperone prolyl 4-hydroxylase, beta polypeptide (P4HB) promotes malignant phenotypes in glioma via MAPK signaling

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