Exploring wind direction and SO2 concentration by circular-linear density estimation

The study of environmental problems usually requires the description of variables with different nature and the assessment of relations between them. In this work, an algorithm for flexible estimation of the joint density for a circular-linear variable is proposed. The method is applied for exploring the relation between wind direction and SO2 concentration in a monitoring station close to a power plant located in Galicia (NW-Spain), in order to compare the effectiveness of precautionary measures for pollutants reduction in two different years.Comment: 17 pages, 7 figures, 2 table

La economía colaborativa: especial análisis del sector del alojamiento y su situación actual

La economía colaborativa ha tenido un gran crecimiento en los últimos años, especialmente en el transporte y alojamiento colaborativo, los cuales son claves para un sector estratégico como es el turismo. Su importancia es tal que se ha producido una transformación completa de este sector. El desarrollo de la economía colaborativa y su impacto en el turismo comenzó antes de la pandemia, pero se ha visto ralentizada por ella desde el año 2020. Por todo ello, el objetivo principal que se persigue con la siguiente investigación es obtener una panorámica general de la economía colaborativa, y en especial del alojamiento colaborativo, estudiando su relación con el turismo y su situación actual.Grado en Marketing e Investigación de Mercado

Image Feature Extraction Acceleration

Image feature extraction is instrumental for most of the best-performing algorithms in computer vision. However, it is also expensive in terms of computational and memory resources for embedded systems due to the need of dealing with individual pixels at the earliest processing levels. In this regard, conventional system architectures do not take advantage of potential exploitation of parallelism and distributed memory from the very beginning of the processing chain. Raw pixel values provided by the front-end image sensor are squeezed into a high-speed interface with the rest of system components. Only then, after deserializing this massive dataflow, parallelism, if any, is exploited. This chapter introduces a rather different approach from an architectural point of view. We present two Application-Specific Integrated Circuits (ASICs) where the 2-D array of photo-sensitive devices featured by regular imagers is combined with distributed memory supporting concurrent processing. Custom circuitry is added per pixel in order to accelerate image feature extraction right at the focal plane. Specifically, the proposed sensing-processing chips aim at the acceleration of two flagships algorithms within the computer vision community: the Viola-Jones face detection algorithm and the Scale Invariant Feature Transform (SIFT). Experimental results prove the feasibility and benefits of this architectural solution.Ministerio de Economía y Competitividad TEC2012-38921-C02, IPT-2011- 1625-430000, IPC-20111009Junta de Andalucía TIC 2338-2013Xunta de Galicia EM2013/038Office of NavalResearch (USA) N00014141035

Diplomado de profundización en farmacovigilancia

En el trabajo realizado damos a conocer cada uno de los temas vistos a lo largo del diplomado de profundización en farmacovigilancia, con la intención de brindar información de calidad a aquellas personas que trabajan en ciencias de la salud puesto que la farmacovigilancia es importante llevarla a cabo tanto a nivel comercial como hospitalaria y en cualquier parte donde se distribuyan o dispensen fármacos ya que es una tarea de todos el velar por la buena salud de las personas, sus riesgo-beneficio, sus contraindicaciones y sobre todo el uso adecuado de los medicamentos y/o dispositivos médicos. también se encontrarán dentro del trabajo temas como el que hacer farmacéutico y su importancia en el área anteriormente mencionada. Cuando hablamos acerca de la Farmacovigilancia, se describe de una gestión en las acciones, utilizada para la prevención de riesgos de los medicamentos en los seres humanos y para evitar los costes económicos relacionados a los efectos adversos no esperados, así mismo mencionamos las características de las reacciones adversas, que se presentan en el día a día, esto quiere decir que la Farmacovigilancia es aquella que se encarga de identificar, contar y evaluar la prevención de los riesgos en el uso de los medicamentos, por tal razón la evaluación que se les hace a los medicamentos es para garantizar su seguridad.In the work carried out, we present each of the topics seen throughout the diploma in deepening in pharmacovigilance, with the intention of providing quality information to those people who work in health sciences since pharmacovigilance is important to carry it out both commercially and in hospitals and anywhere where drugs are distributed or dispensed since it is everyone's task to ensure the good health of people, their risk-benefit, their contraindications and above all the proper use of drugs and / or medical devices. topics such as what to become a pharmacist and its importance in the aforementioned area will also be found within the work. When we talk about pharmacovigilance, a management in actions is described, used for the prevention of drug risks in human beings and to avoid the economic costs related to unexpected adverse effects, we also mention the characteristics of the that occur on a day-to-day basis, this means that pharmacovigilance is the reaction that is responsible for identifying, counting and evaluating the prevention of risks in the use of medications, for this reason the evaluation that is made to the medications is to ensure your safety

Characterization of the striatal extracellular matrix in a mouse model of Parkinson’s disease

Parkinson’s disease’s etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has been neglected. The chemical modifications that might accumulate in matrix components due to their long half-live and the low amount of extracellular antioxidants could also contribute to the disease and explain ineffective cellular therapies. The enriched striatal extracellular matrix from a mouse model of Parkinson’s disease was characterized by Raman spectroscopy. We found a matrix fingerprint of increased oxalate content and oxidative modifications. To uncover the effects of these changes on brain cells, we morphologically characterized the primary microglia used to repopulate this matrix and further quantified the effects on cellular mechanical stress by an intracellular fluorescence resonance energy transfer (FRET)-mechanosensor using the U-2 OS cell line. Our data suggest changes in microglia survival and morphology, and a decrease in cytoskeletal tension in response to the modified matrix from both hemispheres of 6-hydroxydopamine (6-OHDA)-lesioned animals. Collectively, these data suggest that the extracellular matrix is modified, and underscore the need for its thorough investigation, which may reveal new ways to improve therapies or may even reveal new therapies.This research was funded by FEDER (Fundo Europeu de Desenvolvimento Regional) funds through the COMPETE 2020 Operational Program for Competitiveness and Internationalization (POCI), Portugal 2020, and Portuguese funds through FCT (ID/BIM/04293/2020), UnIC (UID/IC/00051/2019), iBiMED (UID/BIM/04501/2020 and POCI-01-0145-FEDER-007628), and LAQV/REQUIMTE (UIDB/50006/2020) research units as well as RV’s Fellowship Grant (IF/00286/2015). Ana Freitas acknowledges FCT for her PhD scholarship (SFRH/BD/111423/2015), Miguel Aroso is hired through the Scientific Employment Stimulus from FCT (CEECIND/03415/2017), and M.L. has an FCT RJEC Id 3762 contract.The authors thank Eduardo D Martín Montiel for his support, fruitful discussions, suggestions, and technical and scientific help. The authors also thank Sofia Lamas and all the i3S Animal facility personnel for their support with the animals throughout the study. Raman spectroscopy, together with wide field and confocal microscopy, were performed at the i3S Scientific Platform Bioimaging, member of the PPBI (Plataforma Portuguesa de Bioimagem, POCI-01-0145-FEDER-022122)

A Small Conductance Calcium-Activated K⁺ Channel in C. elegans, KCNL-2, Plays a Role in the Regulation of the Rate of Egg-Laying

In the nervous system of mice, small conductance calcium-activated potassium (SK) channels function to regulate neuronal excitability through the generation of a component of the medium afterhyperpolarization that follows action potentials. In humans, irregular action potential firing frequency underlies diseases such as ataxia, epilepsy, schizophrenia and Parkinson's disease. Due to the complexity of studying protein function in the mammalian nervous system, we sought to characterize an SK channel homologue, KCNL-2, in C. elegans, a genetically tractable system in which the lineage of individual neurons was mapped from their early developmental stages. Sequence analysis of the KCNL-2 protein reveals that the six transmembrane domains, the potassium-selective pore and the calmodulin binding domain are highly conserved with the mammalian homologues. We used widefield and confocal fluorescent imaging to show that a fusion construct of KCNL-2 with GFP in transgenic lines is expressed in the nervous system of C. elegans. We also show that a KCNL-2 null strain, kcnl-2(tm1885), demonstrates a mild egg-laying defective phenotype, a phenotype that is rescued in a KCNL-2-dependent manner. Conversely, we show that transgenic lines that overexpress KCNL-2 demonstrate a hyperactive egg-laying phenotype. In this study, we show that the vulva of transgenic hermaphrodites is highly innervated by neuronal processes and by the VC4 and VC5 neurons that express GFP-tagged KCNL-2. We propose that KCNL-2 functions in the nervous system of C. elegans to regulate the rate of egg-laying. © 2013 Chotoo et al

How to combine visual features with tags to improve movie recommendation accuracy?

Previous works have shown the effectiveness of using stylistic visual features, indicative of the movie style, in content-based movie recommendation. However, they have mainly focused on a particular recommendation scenario, i.e., when a new movie is added to the catalogue and no information is available for that movie (New Item scenario). However, the stylistic visual features can be also used when other sources of information is available (Existing Item scenario). In this work, we address the second scenario and propose a hybrid technique that exploits not only the typical content available for the movies (e.g., tags), but also the stylistic visual content extracted form the movie files and fuse them by applying a fusion method called Canonical Correlation Analysis (CCA). Our experiments on a large catalogue of 13K movies have shown very promising results which indicates a considerable improvement of the recommendation quality by using a proper fusion of the stylistic visual features with other type of features

Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer

<p>Abstract</p> <p>Background</p> <p>Dexamethasone has been reported to reduce postoperative symptoms after different surgical procedures. We evaluated the efficacy of preoperative dexamethasone in ameliorating postoperative nausea and vomiting (PONV), and pain after mastectomy.</p> <p>Methods</p> <p>In this prospective, double-blind, placebo-controlled study, 70 patients scheduled for mastectomy with axillary lymph node dissection were analyzed after randomization to treatment with 8 mg intravenous dexamethasone (<it>n </it>= 35) or placebo (<it>n </it>= 35). All patients underwent standardized procedures for general anesthesia and surgery. Episodes of PONV and pain score were recorded on a visual analogue scale. Analgesic and antiemetic requirements were also recorded.</p> <p>Results</p> <p>Demographic and medical variables were similar between groups. The incidence of PONV was lower in the dexamethasone group at the early postoperative evaluation (28.6% <it>vs</it>. 60%; <it>p </it>= 0.02) and at 6 h (17.2% <it>vs</it>. 45.8%; <it>p </it>= 0.03). More patients in the placebo group required additional antiemetic medication (21 <it>vs</it>. 8; <it>p </it>= 0.01). Dexamethasone treatment significantly reduced postoperative pain just after surgery (VAS score, 4.54 ± 1.55 <it>vs</it>. 5.83 ± 2.00; <it>p </it>= 0.004), at 6 h (3.03 ± 1.20 <it>vs</it>. 4.17 ± 1.24; <it>p </it>< 0.0005) and at 12 h (2.09 ± 0.85 <it>vs</it>. 2.54 ± 0.98; <it>p </it>= 0.04). Analgesics were required in more patients of the control group (21 <it>vs</it>. 10; <it>p </it>= 0.008). There were no adverse events, morbidity or mortality.</p> <p>Conclusions</p> <p>Preoperative intravenous dexamethasone (8 mg) can significantly reduce the incidence of PONV and pain in patients undergoing mastectomy with axillary dissection for breast cancer.</p> <p>Trial registration number</p> <p>NCT01116713</p