52 research outputs found
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
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- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
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- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
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- Avila Sanchez FJ
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- Azevedo C
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- Chandrasekharan S
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- Chin II
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- Chisbert Cuenca V
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- Christofaki M
- Christoforidis D
- Chronis C
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- Chukkambotla S
- Chung CKE
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- Cirstea E
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- Dumitrascu CO
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- Yao S
- Yao Y
- Yap HL
- Yarwood J
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- Ye H
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- Yeh E
- Yin N
- Yip CP
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- Zamudio D
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- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Enhancing Patient Flexibility of Subcutaneous Immunoglobulin G Dosing: Pharmacokinetic Outcomes of Various Maintenance and Loading Regimens in the Treatment of Primary Immunodeficiency
- Author
- A Gardulf
- A Gardulf
- A Gardulf
- A Gardulf
- A Gonzalez-Quintela
- C Cunningham-Rundles
- CB Landersdorfer
- CW Tornoe
- DS Yim
- H Chapel
- HD Ochs
- HD Ochs
- HW Eijkhout
- IG Girgis
- J Gracia de
- J Waniewski
- JA Church
- JB Bussel
- L Zhang
- LD Notarangelo
- M Ballow
- M Berger
- M Berger
- M Borte
- M Borte
- MA Park
- ME Rose
- MR Stein
- N Shehata
- P Quartier
- PJ Busse
- R Gustafson
- R Madabushi
- R Shapiro
- RH Buckley
- RL Wasserman
- RL Wasserman
- RS Shapiro
- S Hariharan
- S Skoda-Smith
- U Nicolay
- V Gouilleux-Gruart
- V Lougaris
- VR Bonagura
- W Maeder
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Yung RL
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- Zaffagnini G
- Zambelli VO
- Zanella I
- Zang QS
- Zanivan S
- Zappavigna S
- Zaragoza P
- Zarbalis KS
- Zarebkohan A
- Zarrouk A
- Zeitlin SO
- Zeng J
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- Zhan L
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- Zhu B
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- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
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- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
A user's guide to the Encyclopedia of DNA elements (ENCODE)
- Author
- Abdelhamid RF
- Absher DM
- Abyzov A
- Aken B
- Alioto T
- Altshuler RC
- Amrhein H
- Antonarakis SE
- Auerbach RK
- Balasubramanian S
- Bansal A
- Barber GP
- Battenhouse A
- Batut P
- Batzoglou S
- Beal K
- Bell I
- Bell K
- Bernstein BE
- Bhardwaj N
- Bhinge AA
- Bickel PJ
- Bignell A
- Bild N
- Birney E
- Blahnik KR
- Boley N
- Borel C
- Bowling KM
- Boychenko V
- Boyle AP
- Brazma A
- Brent M
- Brown JB
- Brown RH
- Buske OJ
- Canfield T
- Cao AR
- Carninci P
- Cayting P
- Chakrabortty S
- Charos A
- Chen X
- Cheng C
- Chittur S
- Chrast J
- Cline MS
- Collins PJ
- Coyne MJ
- Crawford GE
- Davis CA
- Dekker J
- Derrien T
- DeSalvo G
- Despacio-Reyes G
- Diekhans M
- Dillon LAL
- Dilocker JA
- Djebali S
- Dobin A
- Dong X
- Doyle F
- Drenkow J
- Dreszer TR
- Du J
- Dumais E
- Dumais J
- Dunham I
- Durham T
- Ebersol AK
- Elnitski L
- Epstein CB
- Ernst J
- Euskirchen G
- Farnham PJ
- Feingold EA
- Fejes K
- Fisher K
- Fleming JD
- Frankish A
- Frietze S
- Frum T
- Fujita PA
- Furey TS
- Gao H
- Gerstein M
- Gertz J
- Gibson T
- Giddings MC
- Gingeras TR
- Giresi PG
- Giste E
- Good PJ
- Gordon A
- Graison EAY
- Grasfeder LL
- Green ED
- Grossman RL
- Grubert F
- Guigo R
- Gunawardena H
- Habegger L
- Hannon G
- Hardison RC
- Hariharan M
- Harris RS
- Harrow J
- Harte R
- Haugen E
- Haussler D
- Hayashizaki Y
- Herrero J
- Hoffman MM
- Howald C
- Huang H
- Hubbard T
- Humbert R
- Hunt T
- Issner R
- Iyengar S
- Iyer VR
- Jain P
- Jameel N
- Jee J
- Jha S
- Johnson A
- Johnson EM
- Kapranov P
- Karmakar S
- Karolchik D
- Kasowski M
- Kaul R
- Kay M
- Keefe D
- Kellis M
- Kent WJ
- Khatun J
- Kheradpour P
- Khurana E
- Kim SKC
- King B
- Kingswood C
- Kirilusha A
- Knowles DG
- Kokocinski F
- Ku M
- Kuhn RM
- Kundaje A
- Kutyavin T
- Lacroute P
- Lagarde J
- Lajoie BR
- Lam H
- Lamarre N
- Landt SG
- Lassmann T
- Learned K
- Lee B-K
- Lee K
- Leng J
- Li Q
- Lian J
- Libbrecht M
- Lieb JD
- Lin M
- Lin MF
- Lin W
- Lindahl M
- Liu Z
- Lochovsky L
- London D
- Lotakis D
- Lowdon RF
- Lu Z
- Lukk M
- Luscombe NM
- Maier C
- Malladi VS
- Margulies EH
- Marinov G
- Mariotti M
- McCue K
- McDaniell RM
- Merkel A
- Meyer LR
- Mikkelsen TS
- Miller W
- Miotto B
- Monahan H
- Moqtaderi Z
- Mortazavi A
- Mukherjee G
- Muratet MA
- Myers RM
- Navas PA
- Neph S
- Neri J
- Nesmith AS
- Newberry KM
- Newburger P
- Nguyen ED
- Noble WS
- O'Geen H
- Parker SCJ
- Parker SL
- Partridge EC
- Patacsil D
- Paten B
- Pauli F
- Penalva LO
- Pepke S
- Poh WT
- Preall J
- Pusey B
- Raha D
- Raney BJ
- Rauch R
- Reddy TE
- Reed B
- Reymond A
- Reynolds A
- Rhead B
- Ribeca P
- Risk B
- Roach V
- Roberts K
- Robilotto R
- Rodriguez JM
- Rosenbloom KR
- Roskin K
- Rozowsky J
- Ruan X
- Ruan Y
- Rynes E
- Sabo PJ
- Sammeth M
- Sanchez ME
- Sandstrom R
- Sanyal A
- Saunders G
- Sboner A
- Schlesinger F
- Searle S
- Shafer T
- Shahab A
- Sheffer HH
- Sheffield NC
- Sherlock G
- Shestak C
- Shi M
- Shibata Y
- Shoresh N
- Showers KA
- Sidow A
- Slifer T
- Sloan CA
- Snyder M
- Sobral D
- Song G
- Song L
- Sotirova V
- Sprouse RO
- Stamatoyannopoulos J
- Stamatoyannopoulos JA
- Struhl K
- Suh B
- Swing VK
- Takahashi H
- Tanzer A
- Tenenbaum SA
- Thibeault K
- Thurman RE
- Tilgner H
- Tress M
- Trinklein ND
- Trout D
- Truong T
- Tullius TD
- Ucla C
- Valencia A
- Vales T
- van Baren MJ
- Vaquerizas JM
- Varley KE
- Victorsen A
- Vielmetter J
- Vong S
- Waite LL
- Wang H
- Wang J
- Wang L
- Wang T
- Ward LD
- Weaver M
- Wei C-L
- Weissman SM
- Weng Z
- White KP
- Whitfield TW
- Wilder SP
- Williams B
- Winter D
- Wold B
- Wu L
- Xi H
- Xu X
- Xu Y
- Yan K-K
- Yang X
- Yip KY
- Yu Y
- Zaleski C
- Zhang X
- Zhang Z
- Zweig AS
- Publication venue
- Publication date
- 19/04/2011
- Field of study
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome
Recommended from our members
Commercially Available Immunoglobulins Contain Virus Neutralizing Antibodies Against All Major Genotypes of Polyomavirus BK
- Publication venue
- eScholarship, University of California
- Publication date
- 01/04/2015
- Field of study
Neutralizing antibodies (NAbs) form the basis of immunotherapeutic strategies against many important human viral infections. Accordingly, we studied the prevalence, titer, genotype-specificity, and mechanism of action of anti-polyomavirus BK (BKV) NAbs in commercially available human immune globulin (IG) preparations designed for intravenous (IV) use. Pseudovirions (PsV) of genotypes Ia, Ib2, Ic, II, III, and IV were generated by co-transfecting a reporter plasmid encoding luciferase and expression plasmids containing synthetic codon-modified VP1, VP2, and VP3 capsid protein genes into 293TT cells. NAbs were measured using luminometry. All IG preparations neutralized all BKV genotypes, with mean EC50 titers as high as 254 899 for genotype Ia and 6,666 for genotype IV. Neutralizing titers against genotypes II and III were higher than expected, adding to growing evidence that infections with these genotypes are more common than currently appreciated. Batch to batch variation in different lots of IG was within the limits of experimental error. Antibody mediated virus neutralizing was dose dependent, modestly enhanced by complement, genotype-specific, and achieved without effect on viral aggregation, capsid morphology, elution, or host cell release. IG contains potent NAbs capable of neutralizing all major BKV genotypes. Clinical trials based on sound pharmacokinetic principles are needed to explore prophylactic and therapeutic applications of these anti-viral effects, until effective small molecule inhibitors of BKV replication can be developed
Holographic Display of 3D Data
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1992
- Field of study
Practical Renal Allograft Pathology
- Author
- AJ Matas
- AO Ojo
- B Sis
- BA Alexiev
- BJ Nankivell
- BJ Nankivell
- BL Kasiske
- C Lefaucheur
- C Wiebe
- CB Drachenberg
- CB Drachenberg
- CB Drachenberg
- CB Drachenberg
- CB Drachenberg
- DW Lappin
- FG Cosio
- G Einecke
- GW Barone
- H Ekberg
- H Kort de
- HH Hirsch
- I Batal
- J Sellares
- JA Saikali
- JC Papadimitriou
- JC Papadimitriou
- JM Sorof
- JR Chapman
- K Solez
- L Storsley
- LC Racusen
- LE Fonseca Jr
- LW Gaber
- M Ahmad
- M Haas
- M Haas
- M Haas
- M Naesens
- M Noris
- M Onuigbo
- M Valente
- MA Josephson
- MD Stegall
- MR Laftavi
- N Issa
- P Liptak
- P Randhawa
- P Randhawa
- PP Reese
- PS Randhawa
- RB Colvin
- RB Munivenkatappa
- RS Gaston
- S Baid-Agrawal
- S Hariharan
- SM Bonsib
- TA Huebner
- TN Buchmann
- V Nickeleit
- WM Howell
- WW Williams
- ZM El-Zoghby
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Safety and Efficacy of Tranexamic Acid in Adult Spinal Deformity Surgery: A Systematic Review and Meta-Analysis
- Author
- A Crescenti
- A Khurana
- Alexander F. C. Hulsbergen
- B Yang
- CB Begg
- Christian D. Cerecedo-Lopez
- Dhwani Hariharan
- G Li
- Hasan Zaidi
- HY Choi
- Joanne Doucette
- JPT Higgins
- Kelicia Daniels
- Kerilyn Petrucci
- Linda S. Aglio
- M Egger
- Marco Mammi
- ME Elzik
- Nayan Lamba
- Rania A. Mekary
- SS Hu
- Stefania Papatheodorou
- Timothy R. Smith
- W Dietrich
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Synthesis and characterization of poly(arylene ether) containing cyanate ester networks
- Author
- AJ Kinloch
- CB Bucknall
- CP Reghunadhan Nair
- CP Reghunadhan Nair
- DJ Hourston
- DW Krevelen Van
- Ganesan Anuradha
- JB Cho
- JC Abed
- JW Hwang
- JW Hwang
- K Yamanaka
- M Akay
- M Bauer
- M Dona
- MD Martin
- MF Grenier-Loustalot
- ML Ramirez
- Muthusamy Sarojadevi
- NCP Reghunadhan
- NCP Reghunadhan
- O Grigoryeva
- PA Oyanguren
- R Hariharan
- R Jie Yeh
- SA Srinivasan
- SC Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Arrayed cellular microenvironments for identifying culture and differentiation conditions for stem, primary and rare cell populations
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …