Launching of an intercomparative network in food bacteriology

Dans la perspective du marché unique européen, la France doit se doter d'un système de maîtrise de la qualité des aliments. En particulier, les laboratoires d'analyses devront garantir leurs performances par l'ob tention d'une accréditation. Les procédures d’accréditation comprennent, outre les normes d'organi sation et de gestion, un certain nombre de données fonctionnelles basées sur l'exploitation des résultats des chaînes d’analyses d’intercomparaison. Une initiative a été prise dans ce sens par un groupe formé au sein de deux associations ; une chaîne d'analyses intercomparatives en bacté riologie des aliments fonctionne depuis janvier 1988. Plus de 125 labora toires publics et privés y participent. A l’issue des 4 premiers envois, une synthèse des constatations est effectuée et les perspectives de développement sont évoquées.In view of the EEC Unique Market, France has to settle a food quality control system. In particular, analysis laboratories will have to guarantee their performances by the obtainment of an accreditation. Accreditation procedures include, beyond organization and management standards, a certain number of fonctionnai datas, based on the exploitation of results from intercomparative analysis chains. To this effect, an initiative has been taken by a group whose members belong to two associations ; an intercomparative analysis network in food bacteriology works since January 1988. More than 125 laboratories, public or private, take part of it. At the end of the 4 first sample sendings, a synthesis is done, and development prospects are evocated

Chagas Disease, France

Chagas Disease, Franc

Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer’s disease

The relationship between neuroinflammation and cognition remains uncertain in early Alzheimer’s disease (AD). We performed a cross-sectional study to assess how neuroinflammation is related to cognition using TSPO PET imaging and a multi-domain neuropsychological assessment. A standard uptake value ratio (SUVR) analysis was performed to measure [18F]-DPA-714 binding using the cerebellar cortex or the whole brain as a (pseudo)reference region. Among 29 patients with early AD, the pattern of neuroinflammation was heterogeneous and exhibited no correlation with cognition at voxel-wise, regional or whole-brain level. The distribution of the SUVR values was independent of sex, APOE phenotype, early and late onset of symptoms and the presence of cerebral amyloid angiopathy. However, we were able to demonstrate a complex dissociation as some patients with similar PET pattern had opposed neuropsychological profiles while other patients with opposite PET profiles had similar neuropsychological presentation. Further studies are needed to explore how this heterogeneity impacts disease progression

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Métabolisme intraentérocytaire et absorption par la voie sanguine des acides caprique et oléique chez le rat témoin et traité par l'actidione-cycloheximide

International audienc

Etude biochimique et morphologique des particules lipoprotéiques de la lymphe intestinale de rat au cours de l'absorption d'acide oléique ou de son isomère trans, l'acide étaïdique

International audienc

Le rôle du chirurgien dentiste non hospitalier dans la prise en charge des cancers des voies aéro-digestives supérieures

LILLE2-BU Santé-Recherche (593502101) / SudocLILLE2-UFR Odontologie (593502202) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Etude de l'absorption de l'acide oléique en culture organotypique d'intestin de souris. Influence de la monensine et du nocodazole

International audienc

Absorption intestinale de l'acide linoléique par la voie sanguine chez le rat

International audienc