143 research outputs found
Thermochemistry and kinetics of the trans-N2H2+N reaction
AbstractThermochemical and kinetics properties of the hydrogen abstraction and addition processes of the trans-N2H2+N reaction were computed using high-level ab initio and DFT approximation methods with aug-cc-pVXZ (X=T,Q) basis set. The CCSD (T)/CBS//BB1K/aug-cc-pVTZ results for classical barrier height are 13.1 and 15.0kcal/mol for the abstraction and addition reactions, respectively. The thermal rate constants were calculated using the dual-level direct dynamics by variational transition state theory with the BB1K potential energy surface and thermochemical properties corrected with the CCSD (T)/CBS//BB1K/aug-cc-pVTZ results. The rate constants calculated show that the variational and tunneling effects play a relevant role only for the abstraction reaction
General 2 charge geometries
Two charge BPS horizon free supergravity geometries are important in
proposals for understanding black hole microstates. In this paper we construct
a new class of geometries in the NS1-P system, corresponding to solitonic
strings carrying fermionic as well as bosonic condensates. Such geometries are
required to account for the full microscopic entropy of the NS1-P system. We
then briefly discuss the properties of the corresponding geometries in the dual
D1-D5 system.Comment: 44 page
Approximate solution of the Duffin-Kemmer-Petiau equation for a vector Yukawa potential with arbitrary total angular momenta
The usual approximation scheme is used to study the solution of the
Duffin-Kemmer-Petiau (DKP) equation for a vector Yukawa potential in the
framework of the parametric Nikiforov-Uvarov (NU) method. The approximate
energy eigenvalue equation and the corresponding wave function spinor
components are calculated for arbitrary total angular momentum in closed form.
Further, the approximate energy equation and wave function spinor components
are also given for case. A set of parameter values is used to obtain the
numerical values for the energy states with various values of quantum levelsComment: 17 pages; Communications in Theoretical Physics (2012). arXiv admin
note: substantial text overlap with arXiv:1205.0938, and with
arXiv:quant-ph/0410159 by other author
Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction
Three-dimensional genome organisation and replication timing are known to be correlated, however, it remains unknown whether nuclear architecture overall plays an instructive role in the replication-timing programme and, if so, how. Here we demonstrate that RIF1 is a molecular hub that co-regulates both processes. Both nuclear organisation and replication timing depend upon the interaction between RIF1 and PP1. However, whereas nuclear architecture requires the full complement of RIF1 and its interaction with PP1, replication timing is not sensitive to RIF1 dosage. The role of RIF1 in replication timing also extends beyond its interaction with PP1. Availing of this separation-of-function approach, we have therefore identified in RIF1 dual function the molecular bases of the co-dependency of the replication-timing programme and nuclear architecture
Theory-Motivated Benchmark Models and Superpartners at the Tevatron
Recently published benchmark models have contained rather heavy
superpartners. To test the robustness of this result, several benchmark models
have been constructed based on theoretically well-motivated approaches,
particularly string-based ones. These include variations on anomaly and
gauge-mediated models, as well as gravity mediation. The resulting spectra
often have light gauginos that are produced in significant quantities at the
Tevatron collider, or will be at a 500 GeV linear collider. The signatures also
provide interesting challenges for the LHC. In addition, these models usually
account for electroweak symmetry breaking with relatively less fine-tuning than
previous benchmark models.Comment: 44 pages, 4 figures; some typos corrected. Revisions reflect
published versio
Spinning Strings as Small Black Rings
Certain supersymmetric elementary string states with spin can be viewed as
small black rings whose horizon has the topology of S^1 \times S^{d-3} in a
d-dimensional string theory. By analyzing the singular black ring solution in
the supergravity approximation, and using various symmetries of the \alpha'
corrected effective action we argue that the Bekenstein-Hawking-Wald entropy of
the black string solution in the full string theory agrees with the statistical
entropy of the same system up to an overall normalization constant. While the
normalization constant cannot be determined by the symmetry principles alone,
it can be related to a similar normalization constant that appears in the
expression for small black holes without angular momentum in one less
dimension. Thus agreement between statistical and macroscopic entropy of
(d-1)-dimensional non-rotating elementary string states would imply a similar
agreement for a d-dimensional elementary string state with spin. Our analysis
also determines the structure of the near horizon geometry and provides us with
a geometric derivation of the Regge bound. These studies give further evidence
that a ring-like horizon is formed when large angular momentum is added to a
small black hole.Comment: LaTeX file, 31 pages; v2: references to earlier work adde
Triple negative breast cancer: proposals for a pragmatic definition and implications for patient management and trial design.
In trials in triple negative breast cancer (TNBC), oestrogen and progesterone receptor negativity should be defined as < 1% positive cells. Negativity is a ratio of <2 between Her2 gene copy number and centromere of chromosome 17 or a copy number of 4 or less. In routine practice, immunohistochemistry is acceptable given stringent quality assurance. Triple negativity emerging after neoadjuvant treatment differs from primary TN and such patients should not enter TNBC trials. Patients relapsing with TN metastases should be eligible even if their primary was positive. Rare TN subtypes such as apocrine, adenoid-cystic and low-grade metaplastic tumours should be excluded. TN and basal-like (BL) signatures overlap but are not equivalent. Since the significance of basal cytokeratin or EGFR overexpression is not known and we lack validated assays, these features should not be used to subclassify TN tumours. Tissue collection in trials is mandatory so the effect on outcome of different tumour phenotypes and BRCA mutation can be explored. No prospective studies have established that TN tumours have particular sensitivity or resistance to any specific chemotherapy agent or radiation. TNBC patients should be treated according to tumour and clinical characteristics
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