Application of shallow seismic profiling to study riverbed architectural facies: a case study of the Tocantins river (Pará - Brazil)

To date, the vast majority of river sedimentology study has relied on two main categories of observation: direct observation of shallow trenches, cut faces and cores or geophysical survey on dry and shallow regions of braid bars. In this study, a sub-bottom profiler was used to investigate the stratigraphy of the lower course of the Tocantins River in the Amazon region, between the city of Tucuruì and the village of Nazaré dos Patos. The interest in this specific region lies on the possible variation of the fluvial regime due to the installation of the dam of the Tucuruì hydroelectric plant and the perspective that such river would become navigable as soon as the canal lock will be completed. Collected data show a detailed variety and complexity of architectural elements, as well as internal structure of sandy macroforms. Furthermore, the results allowed the identification of three main environments linked to channel sedimentation processes: by-pass, transition and deposition environments, whose distribution is linked to channel dynamics and bedrock topography. The application of the study is manifold, once it provides not only an insight into sedimentary structure of alluvial forms and sedimentation history, but also elements demanded to plan eventual engineering works for river navigability.Até hoje, a maior parte dos estudos de sedimentologia fluvial tem adotado dois principais métodos de investigação: observação direta de trincheiras, faces expostas e testemunhos, ou levantamento geofísico nas regiões emersas ou rasas das barras fluviais. Neste estudo, um perfilador acústico de subfundo foi utilizado para investigar a estratigrafia do baixo curso do Rio Tocantins, na bacia Amazônica, entre a cidade de Tucuruí e a vila de Nazaré dos Patos. O interesse neste trecho do rio reside na possível variação do regime fluvial devido à instalação da barragem da usina hidrelétrica de Tucuruí e à perspectiva de que este rio se torne navegável após a conclusão da construção da eclusa. Os perfis coletados mostram detalhes da variedade e complexidade de elementos arquiteturais e a estrutura interna das macroformas arenosas. Além disso, os resultados permitiram a identificação de três ambientes correlacionados com os processos sedimentares ativos no canal: ambientes de by-pass, transição e deposição, que estão relacionados à dinâmica do canal e topografia do embasamento. A aplicação deste estudo é multíplice, uma vez que fornece informações sobre a estrutura sedimentar das formas aluvionais e histórico de deposição, mostra elementos necessários ao planejamento de eventuais intervenções para a navegabilidade do rio

Carcass characteristics and meat quality of sheep fed buffelgrass silage to replace corn silage

The aim of the study was to evaluate the carcass characteristics, proximate composition, and sensorial attributes of meat from sheep fed diets in which buffelgrass silage replaced corn silage. Thirty-two intact male crossbred Santa Inês sheep with an average live weight of 20.09 ± 2.0 kg were housed in individual stalls and allotted at random to four treatments in which corn silage was replaced by buffelgrass silage at the levels of 0 (control), 33.3%, 66.6%, and 100%. After an adaption period of 10 days, the sheep were fed for an additional 61 days. Feed was offered ad libitum and corn silage comprised 60% of the diet for the control group. Carcass characteristics, non-carcass components and meat quality were evaluated. Hot carcass yield, cold carcass yield, true carcass yield, trimmings, fat weight, and mesenteric and omental fat weight were highest for the control group (P <0.05). Loin eye area had a quadratic response (P =0.02), with the largest areas being observed in animals fed the diet containing 66.6% buffelgrass silage. Liver weight (P <0.01), luminosity of the meat (P <0.05), and cooking loss (P <0.05) likewise had nonlinear responses to the concentration of buffelgrass silage in the diet. The treatments did not have significant negative influence on the nutritional and organoleptic characteristics of the meat

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2015 and GOLD 2019 staging: a pooled analysis of individual patient data

In 2019, The Global Initiative for Chronic Obstructive Lung Disease (GOLD) modified the grading system for patients with COPD, creating 16 subgroups (1A-4D). As part of the COPD Cohorts Collaborative International Assessment (3CIA) initiative, we aim to compare the mortality prediction of the 2015 and 2019 COPD GOLD staging systems. We studied 17 139 COPD patients from the 3CIA study, selecting those with complete data. Patients were classified by the 2015 and 2019 GOLD ABCD systems, and we compared the predictive ability for 5-year mortality of both classifications. In total, 17139 patients with COPD were enrolled in 22 cohorts from 11 countries between 2003 and 2017; 8823 of them had complete data and were analysed. Mean +/- SD age was 63.9 +/- 9.8 years and 62.9% were male. GOLD 2019 classified the patients in milder degrees of COPD. For both classifications, group D had higher mortality. 5-year mortality did not differ between groups B and C in GOLD 2015; in GOLD 2019, mortality was greater for group B than C. Patients classified as group A and B had better sensitivity and positive predictive value with the GOLD 2019 classification than GOLD 2015. GOLD 2015 had better sensitivity for group C and D than GOLD 2019. The area under the curve values for 5-year mortality were only 0.67 (95% CI 0.66-0.68) for GOLD 2015 and 0.65 (95% CI 0.63-0.66) for GOLD 2019. The new GOLD 2019 classification does not predict mortality better than the previous GOLD 2015 system

Sex differences between women and men with COPD: A new analysis of the 3CIA study

Background: There is partial evidence that COPD is expressed differently in women than in men, namely on symptoms, pulmonary function, exacerbations, comorbidities or prognosis. There is a need to improve the characterization of COPD in females. Methods: We obtained and pooled data of 17 139 patients from 22 COPD cohorts and analysed the clinical differences by sex, establishing the relationship between these characteristics in women and the prognosis and severity of the disease. Comparisons were established with standard statistics and survival analysis, including crude and multivariate Cox-regression analysis. Results: Overall, 5355 (31.2%) women were compared with men with COPD. Women were younger, had lower pack-years, greater FEV1%, lower BMI and a greater number of exacerbations (all p < 0.05). On symptoms, women reported more dyspnea, equal cough but less expectoration (p < 0.001). There were no differences in the BODE index score in women (2.4) versus men (2.4) (p = 0.5), but the distribution of all BODE components was highly variable by sex within different thresholds of BODE. On prognosis, 5-year survival was higher in COPD females (86.9%) than in males (76.3%), p < 0.001, in all patients and within each of the specific comorbidities that we assessed. The crude and adjusted RR and 95% C.I. for death in males was 1.82 (1.69–1.96) and 1.73 (1.50–2.00), respectively. Conclusions: COPD in women has some characteristic traits expressed differently than compared to men, mainly with more dyspnea and COPD exacerbations and less phlegm, among others, although long-term survival appears better in female COPD patients