Transformation and tumorigenicity testing of simian cell lines and evaluation of poliovirus replication

The key role of cell cultures in different scientific fields is worldwide recognized, both as in vitro research models alternative to laboratory animals and substrates for biological production. However, many safety concerns rise from the use of animal/human cell lines that may be tumorigenic, leading to potential adverse contaminations in cell-derived biologicals. In order to evaluate the suitability of 13 different cell lines for Poliovirus vaccine production, safety and quality, in vitro/in vivo tumorigenicity and Poliovirus propagation properties were evaluated. Our results revealed that non-human primate cell lines CYNOM-K1, FRhK-4, 4MBr-5 and 4647 are free of tumorigenic features and represent highly susceptible substrates for attenuated Sabin Poliovirus strains. In particular, FRhK-4 and 4647 cell lines are characterized by a higher in vitro replication, resulting indicated for the use in large-scale production field

EFEITOS DA POLÍTICA DE SALÁRIO MÍNIMO SOBRE O MERCADO DE TRABALHO METROPOLITANO: UMA ANÁLISE EMPÍRICA A PARTIR DE VETORES AUTORREGRESSIVOS (VAR) - (2003-2015)

RESUMO Com intuito de verificar os efeitos que a política de salário mínimo exerce sobre o mercado de trabalho metropolitano brasileiro, o presente estudo contribui ao verificar a sua inter-relação com variáveis como taxa de atividade, grau de informalidade e taxa de desemprego em quatro regiões metropolitanas (Recife, Porto Alegre, Belo Horizonte e São Paulo), separadamente, no período de janeiro de 2003 a março de 2015. Ao utilizar o método de autorregressão vetorial (VAR), os resultados mostram que a relação entre salário mínimo e taxa de atividade se deu com ingresso de mão de obra apenas em uma região estudada. Nas demais regiões observam-se tanto uma tendência de queda no grau de informalidade quanto um aumento na taxa de desemprego

Wage differentials associated with race between 2002 and 2014 in Brazil: Evidence from a quantile decomposition

Throughout the 2000s Brazil went through a great phase of economic development. The present study seeks to investigate whether this movement was accompanied by a reduction in inequality in the labor market, measured here by the wage gap between whites and non-whites. To do so, three cohorts of time (2002-2004, 2007-2009 and 2012-2014) were analyzed from the microdata of the National Household Sampling Survey (Pesquisa Nacional de Amostragem Domiciliar - PNAD). The applied method is the counterfactual Oaxaca-Blinder along with the Recentered Influence Function Regression (RIF-Regression) so that the main determinants of wages inequalities can be detailed throughout the salary distribution. Our results showed that wage gap (totals, due to observed factors and discrimination) are higher in the higher quantiles of the distribution, that is, in professions or activities with higher wages. The results also point to a salary approximation between the groups during the analyzed period, which was mainly due to observable characteristics, specially education levels. However, discrimination decreased only between the first and second triennium and in low magnitude. Apart from that, the main determinants of racial wage gap are returns to education, experience and professions considered unregulated (self-employment and informal workers)

Bolsa Família: um survey sobre os efeitos do programa de transferência de renda condicionada do Brasil

Revisam-se pesquisas sobre efeitos do Programa Bolsa Família. Há quatro evidências frequentes. A primeira é que o programa tem focalização relativamente boa, mas que pode ainda ser melhorada. A segunda é o efeito positivo sobre a aquisição (consumo) de alimentos – sem conclusões sobre a qualidade da dieta. A terceira diz respeito ao estimulo às crianças a participarem da escola (matrícula, frequência e progressão), embora pouco se saiba sobre os efeitos na aprendizagem. A ausência de efeitos sobre a fecundidade das mulheres caracteriza a quarta conclusão robusta que se pode tirar da literatura, ainda que mais estudos devam ser realizados. Em outras dimensões, as evidências não formam consenso sobre direção dos efeitos.This paper surveys the literature about the effects of Bolsa Familia Program. We found four main results. The first is that the program is relatively well targeted, but it can still be improved.The second is the positive effect on the acquisition (consumption) of food, but there is no conclusions about the quality of the diet. The third is that the program encourages children to attend school (enrollment, attendance and progression). However, little is known about the effects on learning. The absence of effects on the fecundity of the women characterizes the fourth conclusion that can be drawn from the literature, although more studies must be carried out on this topic. In other dimensions, the evidence does not form consensus on the direction of effects