69 research outputs found
Projective and Coarse Projective Integration for Problems with Continuous Symmetries
Temporal integration of equations possessing continuous symmetries (e.g.
systems with translational invariance associated with traveling solutions and
scale invariance associated with self-similar solutions) in a ``co-evolving''
frame (i.e. a frame which is co-traveling, co-collapsing or co-exploding with
the evolving solution) leads to improved accuracy because of the smaller time
derivative in the new spatial frame. The slower time behavior permits the use
of {\it projective} and {\it coarse projective} integration with longer
projective steps in the computation of the time evolution of partial
differential equations and multiscale systems, respectively. These methods are
also demonstrated to be effective for systems which only approximately or
asymptotically possess continuous symmetries. The ideas of projective
integration in a co-evolving frame are illustrated on the one-dimensional,
translationally invariant Nagumo partial differential equation (PDE). A
corresponding kinetic Monte Carlo model, motivated from the Nagumo kinetics, is
used to illustrate the coarse-grained method. A simple, one-dimensional
diffusion problem is used to illustrate the scale invariant case. The
efficiency of projective integration in the co-evolving frame for both the
macroscopic diffusion PDE and for a random-walker particle based model is again
demonstrated
Reduced order models for control of fluids using the Eigensystem Realization Algorithm
In feedback flow control, one of the challenges is to develop mathematical
models that describe the fluid physics relevant to the task at hand, while
neglecting irrelevant details of the flow in order to remain computationally
tractable. A number of techniques are presently used to develop such
reduced-order models, such as proper orthogonal decomposition (POD), and
approximate snapshot-based balanced truncation, also known as balanced POD.
Each method has its strengths and weaknesses: for instance, POD models can
behave unpredictably and perform poorly, but they can be computed directly from
experimental data; approximate balanced truncation often produces vastly
superior models to POD, but requires data from adjoint simulations, and thus
cannot be applied to experimental data.
In this paper, we show that using the Eigensystem Realization Algorithm (ERA)
\citep{JuPa-85}, one can theoretically obtain exactly the same reduced order
models as by balanced POD. Moreover, the models can be obtained directly from
experimental data, without the use of adjoint information. The algorithm can
also substantially improve computational efficiency when forming reduced-order
models from simulation data. If adjoint information is available, then balanced
POD has some advantages over ERA: for instance, it produces modes that are
useful for multiple purposes, and the method has been generalized to unstable
systems. We also present a modified ERA procedure that produces modes without
adjoint information, but for this procedure, the resulting models are not
balanced, and do not perform as well in examples. We present a detailed
comparison of the methods, and illustrate them on an example of the flow past
an inclined flat plate at a low Reynolds number.Comment: 22 pages, 7 figure
Managing the Knowledge Creation Process of Large-Scale Evaluation Campaigns
Περιέχει το πλήρες κείμενοThis paper discusses the evolution of large-scale evaluation
campaigns and the corresponding evaluation infrastructures needed to
carry them out. We present the next challenges for these initiatives and
show how digital library systems can play a relevant role in supporting
the research conducted in these fora by acting as virtual research
environments
MidA is a putative methyltransferase that is required for mitochondrial complex I function
10 páginas, 6 figuras.-- et al.Dictyostelium and human MidA are homologous proteins that belong to a family of proteins of unknown function called DUF185. Using yeast two-hybrid screening and pull-down experiments, we showed that both proteins interact with the mitochondrial complex I subunit NDUFS2. Consistent with this, Dictyostelium cells lacking MidA showed a specific defect in complex I activity, and knockdown of human MidA in HEK293T cells resulted in reduced levels of assembled complex I. These results indicate a role for MidA in complex I assembly or stability. A structural bioinformatics analysis suggested the presence of a methyltransferase domain; this was further supported by site-directed mutagenesis of specific residues from the putative catalytic site. Interestingly, this complex I deficiency in a Dictyostelium midA- mutant causes a complex phenotypic outcome, which includes phototaxis and thermotaxis defects. We found that these aspects of the phenotype are mediated by a chronic activation of AMPK, revealing a possible role of AMPK signaling in complex I cytopathology.This work was supported by grants BMC2006-00394 and BMC2009-09050 to R.E. from the Spanish Ministerio de Ciencia e Innovación; to P.R.F. from the Thyne Reid Memorial Trusts and the Australian Research Council; to A.V. and O.G. from the Spanish National Bioinformatics Institute (www.inab.org), a platform of Genome Spain; to R.G. from the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain (PI070167) and from the Comunidad de Madrid (GEN-0269/2006). S.C. is supported by a research contract from Consejería de Educación de la Comunidad de Madrid y del Fondo Social Europeo (FSE).Peer Reviewe
Fast Approximated POD for a Flat Plate Benchmark with a Time Varying Angle of Attack
An approximate POD algorithm provides an empirical Galerkin approximation with guaranteed a priori lower bound on the required resolution. The snapshot ensemble is partitioned into several sub-ensembles. Cross correlations between these sub-ensembles are approximated in terms of a far smaller correlation matrix. Computational speedup is nearly linear in the number of partitions, up to a saturation that can be estimated a priori. The algorithm is particularly suitable for analyzing long transient trajectories of high dimensional simulations, but can be applied also for spatial partitioning and parallel processing of very high spatial dimension data. The algorithm is demonstrated using transient data from two simulations. First, a two dimensional simulation of the flow over a flat plate, as it transitions from AOA = 30° to a horizontal position and back. Second, a three dimensional simulation of a flat plate with aspect ratio two as it transitions from a horizontal position to AOA = 30°
The Sudbury Neutrino Observatory
The Sudbury Neutrino Observatory is a second generation water Cherenkov
detector designed to determine whether the currently observed solar neutrino
deficit is a result of neutrino oscillations. The detector is unique in its use
of D2O as a detection medium, permitting it to make a solar model-independent
test of the neutrino oscillation hypothesis by comparison of the charged- and
neutral-current interaction rates. In this paper the physical properties,
construction, and preliminary operation of the Sudbury Neutrino Observatory are
described. Data and predicted operating parameters are provided whenever
possible.Comment: 58 pages, 12 figures, submitted to Nucl. Inst. Meth. Uses elsart and
epsf style files. For additional information about SNO see
http://www.sno.phy.queensu.ca . This version has some new reference
Recommended from our members
Reduced-Order Model Based Feedback Control For Modified Hasegawa-Wakatani Model
In this work, the development of model-based feedback control that stabilizes an unstable equilibrium is obtained for the Modi ed Hasegawa-Wakatani (MHW) equations, a classic model in plasma turbulence. First, a balanced truncation (a model reduction technique that has proven successful in ow control design problems) is applied to obtain a low dimensional model of the linearized MHW equation. Then a modelbased feedback controller is designed for the reduced order model using linear quadratic regulators (LQR). Finally, a linear quadratic gaussian (LQG) controller, which is more resistant to disturbances is deduced. The controller is applied on the non-reduced, nonlinear MHW equations to stabilize the equilibrium and suppress the transition to drift-wave induced turbulence
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