Why pair production cures covariance in the light-front?

We show that the light-front vaccum is not trivial, and the Fock space for positive energy quanta solutions is not complete. As an example of this non triviality we have calculated the electromagnetic current for scalar bosons in the background field method were the covariance is restored through considering the complete Fock space of solutions. We also show thus that the method of "dislocating the integration pole" is nothing more than a particular case of this, so that such an "ad hoc" prescription can be dispensed altogether if we deal with the whole Fock space. In this work we construct the electromagnetic current operator for a system composed of two free bosons. The technique employed to deduce these operators is through the definition of global propagators in the light front when a background electromagnetic field acts on one of the particles.Comment: 11 pages, 2 figure

Optimization of the supercritical fluid extraction of Quercus cerris cork towards extraction yield and selectivity to friedelin

Optimization of the supercritical fluid extraction of Quercus cerris cork was carried out using Box-Behnken design of experiments and response surface methodology (RSM). The optimized process variables were temperature (T : 40, 50 and 60 °C), ethanol content (EtOH: 0.0, 2.5 and 5.0 wt%) and CO2 flow rate (QCO2: 5, 8 and 11 −g min )1 . The studied responses were total extraction yield (ηTotal), friedelin concentration of the extract (CFriedelin), and selectivity towards friedelin (αF,nF). The linear effect of EtOH was by far the most influent operating condition (Pareto analysis) and the highest yield (ηTotal = 2.2 wt%) was attained with 5.0 wt% EtOH. The RSM model estimates maximum friedelin concentration in the extracts (38.2 wt%) to occur without cosolvent (0 wt% EtOH) for the lowest T (40 °C) and QCO2 (5 −g min )CO2 1 . As for selectivity, the experimental αF,nF values were always higher than 1.0 and reached 3.1 (at 50 °C, 5 wt% EtOH, 11 −g minCO2 1). Altogether, these results suggest friedelin can be selectively removed from Quercus cerris cork by supercritical fluid extraction within the range of experimental conditions studiedpublishe

Schistosomiasis Mansoni In Urban Northeast Brazil: Influence Of Rainfall Regime On The Population Dynamics Of Biomphalaria Sp

Introduction: Our objective was to evaluate the infl uence of rainfall regime on the population dynamics of Biomphalaria in a potential urban focus of schistosomiasis in Aracaju, Brazil, during 2009-2010. Methods: Snails were collected monthly and were counted, measured and identifi ed; the level of infection and fecal contamination at the sampling sites was determined; rainfall data were obtained. Results: High levels of fecal contamination were observed, and the abundance of Biomphalaria glabrata increased during the rainy and post-rainy seasons. The snails' size was variable, and infected snails were identifi ed independently of rainfall. Conclusions: These results provide evidence of anthropogenic and climate interference in an urban focus of schistosomiasis in the Aracaju metropolitan area.465654657Pordeus, L.C., Aguiar, L.R., Quinino, L.R.M., Barbosa, C.S.A., Ocorrência das formas aguda e crônica da esquistossomose mansônica no Brasil no período de 1997 a 2006: Uma revisão de literatura (2008) Epidemiol Serv Saude, 17, pp. 163-175Souza, M.A.A., Barbosa, V.S., Wanderlei, T.N.G., Barbosa, C.S., Criadouros de Biomphalaria, temporários e permanentes, em Jaboatão dos Guararapes, PE (2008) Rev Soc Bras Med Trop, 41, pp. 252-256Araújo, K.C.G.M., Resendes, A.P.C., Souza-Santos, R., Silveira Jr., J.C., Barbosa, C.S., Análise espacial dos focos de Biomphalaria glabrata (Say, 1818) e de casos humanos de esquistossomose mansônica em Porto de Galinhas, Pernambuco, Brasil, no ano 2000 (2007) Cad Saude Publica, 23, pp. 409-417Lima, L.C., Família Planorbidae (1995) Tópicos em Malacologia Médica., pp. 90-112. , In: Barbosa FS, editor. Rio de Janeiro: Fundação Oswaldo Cruz(2005) Resolução CONAMA no 357, , http://www.cetesb.sp.gov.br/Agua/praias/res_conama_357_05.pdf, Conselho Nacional do Meio Ambiente (CONAMA). de 17 de março de. [Cited 2011 February 23]. Available fromSouza, M.A.A., Barbosa, V.S., Albuquerque, J.O., Bocanegra, S., Souza-Santos, R., Paredes, H., Aspectos ecológicos e levantamento malacológico para identificação de áreas de risco para transmissão da esquistossomose mansoni no litoral norte de Pernambuco, Brasil (2010) Iheringia Serie Zoológica, 100, pp. 19-24Barbosa, F.S., Barbosa, C.S., The bioecology of snails vectors for schistosomiasis in Brazil (1994) Cad Saude Publica, 10, pp. 200-209Fernandez, M.A., Thiengo, S.C., Susceptibility of Biomphalaria straminea from Peixe Angical dam, Tocantins, Brazil to infection with three strains of Schistosoma mansoni (2010) Mem Inst Oswaldo Cruz, 105, pp. 488-491Barbosa, C.S., Domingues, A.L.C., Abath, F., Montenegro, S.M.L., Guida, U., Carneiro, J., Epidemia de esquistossomose aguda na praia de Porto de Galinhas, Pernambuco, Brasil (2001) Cad Saude Publica, 17, pp. 725-728Rollemberg, C.V.V., Santos, C.M.B., Silva, M.M.B.L., Souza, A.M.B., Silva, A.M., Almeida, J.A.P., Aspectos epidemiológicos e distribuição geográfica da esquistossomose e geo-helmintos, no Estado de Sergipe, de acordo com os dados do Programa de Controle da Esquistossomose (2011) Rev Soc Bras Med Trop, 44, pp. 91-96Barbosa, C.S., Montenegro, S.M.L., Abath, F.G., Domingues, A.L.C., Eventos epidemiológicos relacionados à transmissão da esquistossomose em áreas rurais e urbanas de Pernambuco (2002) Mem Inst Oswaldo Cruz, 96, pp. 169-172Departamento de Vigilância Epidemiológica (2008) Vigilância e controle de moluscos de importância epidemiológica: Diretrizes técnicas., , Ministério da Saúde. Programa de Vigilância e Controle da Esquistossomose (PCE). 2nded. Brasília: Ministério da Saúd

Low energy collective modes, Ginzburg-Landau theory, and pseudogap behavior in superconductors with long-range pairing interactions

We study the superconducting instability in systems with long but finite ranged, attractive, pairing interactions. We show that such long-ranged superconductors exhibit a new class of fluctuations in which the internal structure of the Cooper pair wave function is soft, and thus lead to "pseudogap" behavior in which the actual transition temperature is greatly depressed from its mean field value. These fluctuations are {\it not} phase fluctuations of the standard superconducting order parameter, and lead to a highly unusual Ginzburg-Landau description. We suggest that the crossover between the BCS limit of a short-ranged attraction and our problem is of interest in the context of superconductivity in the underdoped cuprates.Comment: 20 pages with one embedded ps figure. Minor revisions to the text and references. Final version to appear in PRB on Nov. 1st, 200

The in-plane paraconductivity in La_{2-x}Sr_xCuO_4 thin film superconductors at high reduced-temperatures: Independence of the normal-state pseudogap

The in-plane resistivity has been measured in $La_{2-x}Sr_xCuO_4$ (LSxCO) superconducting thin films of underdoped ($x=0.10,0.12$), optimally-doped ($x=0.15$) and overdoped ($x=0.20,0.25$) compositions. These films were grown on (100)SrTiO$_3$ substrates, and have about 150 nm thickness. The in-plane conductivity induced by superconducting fluctuations above the superconducting transition (the so-called in-plane paraconductivity, $\Delta\sigma_{ab}$) was extracted from these data in the reduced-temperature range 10^{-2}\lsim\epsilon\equiv\ln(T/\Tc)\lsim1. Such a $\Delta\sigma_{ab}(\epsilon)$ was then analyzed in terms of the mean-field--like Gaussian-Ginzburg-Landau (GGL) approach extended to the high-$\epsilon$ region by means of the introduction of a total-energy cutoff, which takes into account both the kinetic energy and the quantum localization energy of each fluctuating mode. Our results strongly suggest that at all temperatures above Tc, including the high reduced-temperature region, the doping mainly affects in LSxCO thin films the normal-state properties and that its influence on the superconducting fluctuations is relatively moderate: Even in the high-$\epsilon$ region, the in-plane paraconductivity is found to be independent of the opening of a pseudogap in the normal state of the underdoped films.Comment: 35 pages including 10 figures and 1 tabl

Avaliação da incidência de antracnose, do desempenho e estado nutricional de variedades de mangueira, para cultivo orgânico, na região centro-norte do Estado de São Paulo.

A mudança do perfil do consumidor, aliada aos riscos da contaminação por agrotóxicos, tem levado à busca de alternativas ecologicamente apropriadas para produção de frutas. Os objetivos deste trabalho foram avaliar a incidência de antracnose, o desempenho e estado nutricional de variedades de mangueira conduzidas organicamente na região de Pindorama-SP. Foram utilizadas 17 variedades de mangueira. O experimento foi instalado em delineamento experimental em blocos completos ao acaso, com 17 tratamentos (variedades) e seis repetições. Foi avaliada a severidade de antracnose nas folhas, através de uma escala diagramática, atribuindo-se notas aos sintomas. Foram avaliados o crescimento e o desenvolvimento (altura da planta, perímetro do tronco e da copa) e o estado nutricional, mediante análise foliar, das diferentes variedades utilizadas. Através dos resultados obtidos, podem-se considerar como muito suscetíveis à antracnose as variedades Bourbon, Rocha e Rosa; e resistentes, as variedades IAC 111, Alfa, Beta e Parvin; as variedades de manga apresentaram o mesmo padrão de crescimento; as maiores alturas da planta corresponderam aos maiores diâmetros do tronco e da copa; a variedade Parvin apresentou o melhor desempenho dentre as variedades estudadas, com relação à resistência à antracnose, altura e diâmetro do caule e da copa, podendo ser recomendada ao cultivo orgânico. As variedades Omega e Alfa também apresentaram bom crescimento, podendo ser indicadas para esse cultivo, pelo menos nessa fase inicial; as variedades Surpresa e Rosa não apresentaram bom desempenho, no campo, em relação às demais, não devendo ser recomendadas para o cultivo orgânico, principalmente a variedade Rosa, bastante suscetível à antracnose. As concentrações de N, P e K foram elevadas na fase vegetativa das plantas, comparadas à baixa concentração de Ca; houve carência de Boro em todas as variedades estudadas. A manga Rosa, provavelmente, sofreu toxicidade ao excesso de manganês, ocasionando diminuição em seu desenvolvimento

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In the last years many populations of anurans have declined and extinctions have been recorded. They were related to environmental pollution, changes of land use and emerging diseases. The main objective of this study was to determine copper sensitivity of the anuran of the Amazon Rhinella granulosa and Scinax ruber tadpoles at stage 25 and Scinax ruber eggs exposed for 96 h to copper concentrations ranging from 15 µg Cu L-1 to 94 µg Cu L-1. LC50 at 96 h of Rhinella granulosa Gosner 25, Scinax ruber Gosner 25 and Scinax ruber eggs in black water of the Amazon were 23.48, 36.37 and 50.02 µg Cu L-1, respectively. The Biotic Ligand Model was used to predict the LC50 values for these species and it can be considered a promising tool for these tropical species and water conditions. Copper toxicity depends on water physical-chemical composition and on the larval stage of the tadpoles. The Gosner stage 19-21 (related to the appearance of external gills) is the most vulnerable and the egg stage is the most resistant. In case of contamination by copper, the natural streams must have special attention, since copper is more bioavailable.Nos últimos anos foram registrados muitas extinções e declínios de populações de anuros. Eles estavam relacionados com a poluição do ambiente, a mudanças no uso da terra e ao surgimento de doenças. O principal objetivo deste estudo foi determinar a sensibilidade dos anuros amazônicos ao cobre. Os girinos de Scinax ruber e Rhinella granulosa no estadio 25 e os ovos de Scinax ruber foram expostos por 96 horas a concentrações de cobre entre 15 µg Cu L-1 a 94 µg Cu L-1. A CL50 -96 h dos girinos de Rhinella granulosa, dos girinos de Scinax ruber e dos ovos de Scinax ruber em águas pretas da Amazônia foram 23,48; 36,37 e 50,02 µg Cu L-1, respectivamente. O modelo do ligante biótico foi usado para prever os valores de CL50 para essas duas espécies e pode ser considerado uma ferramenta promissora para essas espécies tropicais e para essas condições de água. A Toxicidade de cobre depende da composição físico-química da água e do estagio larval dos girinos. O estadio 19-21 de Gosner (relacionados ao aparecimento das brânquias externas) são os mais vulnerável e o estagio de ovo é o mais resistente. Em caso de contaminação por cobre, os igarapés naturais devem ter uma atenção especial, uma vez que o cobre é mais biodisponível nesse ambiente

The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the reservoir of people living with HIV-1 (PLWH). Twenty-eight PLWH on suppressive antiretroviral therapy were randomized (1:1:1:1 ratio) to receive pyrimethamine, valproic acid, both, or no intervention for 14 days. The primary end point was change in cell-associated unspliced (CA US) HIV-1 RNA at days 0 and 14. We observed a rapid, modest, and significant increase in (CA US) HIV-1 RNA in response to pyrimethamine exposure, which persisted throughout treatment and follow-up. Valproic acid treatment alone did not increase (CA US) HIV-1 RNA or augment the effect of pyrimethamine. Pyrimethamine treatment did not result in a reduction in the size of the inducible reservoir. These data demonstrate that the licensed drug pyrimethamine can be repurposed as a BAF complex inhibitor to reverse HIV-1 latency in vivo in PLWH, substantiating its potential advancement in clinical studies.</p