Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke

Carnosine is a naturally occurring pleotropic dipeptide which influences multiple deleterious mechanisms that are activated during stroke. Numerous published studies have reported that carnosine has robust efficacy in ischemic stroke models. To further evaluate these data, we have conducted a systematic review and meta-analysis of published studies. We included publications describing in vivo models of ischemic stroke where the neuroprotective efficacy of carnosine was being evaluated through the reporting of infarct volume and/or neurological score as outcomes. Overall efficacy was evaluated using weighted mean difference random effects meta-analysis. We also evaluated for study quality and publication bias. We identified eight publications that met our inclusion criteria describing a total of 29 comparisons and 454 animals. Overall methodological quality of studies was moderate (median ¼ 4/9). Carnosine reduced infarct volume by 29.4% (95% confidence interval (CI), 24.0% to 34.9%; 29 comparisons). A clear dose-response effect was observed, and efficacy was reduced when carnosine was administered more than 6 h after ischemia. Our findings suggest that carnosine administered before or after the onset of ischemia exhibits robust efficacy in experimental ischemic stroke. However, the methodological quality of some of the studies was low and testing occurred only in healthy young male animals

Motion-Induced Radiation from a Dynamically Deforming Mirror

A path integral formulation is developed to study the spectrum of radiation from a perfectly reflecting (conducting) surface. It allows us to study arbitrary deformations in space and time. The spectrum is calculated to second order in the height function. For a harmonic traveling wave on the surface, we find many different regimes in which the radiation is restricted to certain directions. It is shown that high frequency photons are emitted in a beam with relatively low angular dispersion whose direction can be controlled by the mechanical deformations of the plate.Comment: 4 pages, 2 eps figues included, final version as appeared in PR

Pediatric sleep-related breathing disorders: advances in imaging and computational modeling

We understand now that sleep of sufficient length and quality is required for good health. This is particularly true for infants and children, who have the added physiologic task of growth and development, as compared to their adult counterparts. Sleep-related breathing disorders (SRBDs) are common in childhood and if unrecognized and not treated can result in significant morbidity. For example, children with obstructive sleep apnea (OSA) can exhibit behavioral, mood, and learning difficulties. If left untreated, alterations in the function of the autonomic nervous system and a chronic inflammatory state result, contributing to the risk of heart disease, stroke, glucose intolerance, and hypertension in adulthood

Hypoxia mimetic agents for ischemic stroke

Every year stroke claims more than 6 million lives worldwide. The majority of them are ischemic stroke. Small molecule-based therapeutics for ischemic stroke has attracted a lot of attention, but none has been shown to be clinically useful so far. Hypoxia-inducible factor-1 (HIF-1) plays a crucial role in the transcriptional adaptation of cells to hypoxia. Small molecule-based hypoxia-mimetic agents either stabilize HIF-1α via HIF-prolyl hydroxylases (PHDs) inhibition or through other mechanisms. In both the cases, these agents have been shown to confer ischemic neuroprotection in vitro and in vivo. The agents which act via PHD inhibition are mainly classified into iron chelators, iron competitors, and 2 oxoglutarate (2OG) analogs. This review discusses HIF structure and key players in the HIF-1 degradation pathway as well as the genes, proteins and chemical molecules that are connected to HIF-1 and how they affect cell survival following ischemic injury. Furthermore, this review gives a summary of studies that used PHD inhibitors and other HIF-1α stabilizers as hypoxia-mimetic agents for the treatment of ischemic injury

Spin dynamics of a trapped spin-1 Bose Gas above the Bose-Einstein transition temperature

We study collective spin oscillations in a spin-1 Bose gas above the Bose-Einstein transition temperature. Starting from the Heisenberg equation of motion, we derive a kinetic equation describing the dynamics of a thermal gas with the spin-1 degree of freedom. Applying the moment method to the kinetic equation, we study spin-wave collective modes with dipole symmetry. The dipole modes in the spin-1 system are found to be classified into the three type of modes. The frequency and damping rate are obtained as functions of the peak density. The damping rate is characterized by three relaxation times associated with collisions.Comment: 19 pages, 5 figur

Ground state of a polydisperse electrorheological solid: Beyond the dipole approximation

The ground state of an electrorheological (ER) fluid has been studied based on our recently proposed dipole-induced dipole (DID) model. We obtained an analytic expression of the interaction between chains of particles which are of the same or different dielectric constants. The effects of dielectric constants on the structure formation in monodisperse and polydisperse electrorheological fluids are studied in a wide range of dielectric contrasts between the particles and the base fluid. Our results showed that the established body-centered tetragonal ground state in monodisperse ER fluids may become unstable due to a polydispersity in the particle dielectric constants. While our results agree with that of the fully multipole theory, the DID model is much simpler, which offers a basis for computer simulations in polydisperse ER fluids.Comment: Accepted for publications by Phys. Rev.

The dynamics of quantum phases in a spinor condensate

We discuss the quantum phases and their diffusion dynamics in a spinor-1 atomic Bose-Einstein condensate. For ferromagnetic interactions, we obtain the exact ground state distribution of the phases associated with the total atom number ($N$), the total magnetization (${\cal M}$), and the alignment (or hypercharge) ($Y$) of the system. The mean field ground state is stable against fluctuations of atom numbers in each of the spin components, and the phases associated with the order parameter for each spin components diffuse while dynamically recover the two broken continuous symmetries [U(1) and SO(2)] when $N$ and ${\cal M}$ are conserved as in current experiments. We discuss the implications to the quantum dynamics due to an external (homogeneous) magnetic field. We also comment on the case of a spinor-1 condensate with anti-ferromagnetic interactions.Comment: 5 figures, an extended version of cond-mat/030117

The Scale of Cosmic Isotropy

The most fundamental premise to the standard model of the universe, the Cosmological Principle (CP), states that the large-scale properties of the universe are the same in all directions and at all comoving positions. Demonstrating this theoretical hypothesis has proven to be a formidable challenge. The cross-over scale R_{iso} above which the galaxy distribution becomes statistically isotropic is vaguely defined and poorly (if not at all) quantified. Here we report on a formalism that allows us to provide an unambiguous operational definition and an estimate of R_{iso}. We apply the method to galaxies in the Sloan Digital Sky Survey (SDSS) Data Release 7, finding that R_{iso}\sim 150h^{-1} Mpc. Besides providing a consistency test of the Copernican principle, this result is in agreement with predictions based on numerical simulations of the spatial distribution of galaxies in cold dark matter dominated cosmological models.Comment: 15 pages, 4 figures, accepted by JCAP. The text matches the published versio