Seismic source mechanisms of tremor recorded on Arenal volcano, Costa Rica, retrieved by waveform inversion

International audienceMoment tensor inversions of volcanic tremor are synthetically tested and subsequently applied to a dataset recorded on Arenal volcano in 2005. We selected 15 harmonic tremor events showing an emergent but very clear onset with a fundamental frequency range of 0.8-1.5 Hz. These events constitute an excellent opportunity to broaden our knowledge of tremor generation models. The inversions were performed for a common source location, the position of which was retrieved through the evaluation of the joint probability density function of the misfit values obtained by the moment tensor inversion of all the events and all predefined source locations (grid search). Events are located beneath the summit crater, in a shallow position. The inversion procedure was tested through the use of synthetic tremor, generated using full wavefield numerical simulations. The maximum amplitude decomposition method is used to analyse the solutions of the synthetic tests. The results highlight the stability of the moment tensor solution when the whole length of the signal is used in the inversion procedure. Hence the whole length of the tremor is utilised to retrieve the source mechanism generating the 15 tremor events. A sliding window is utilised to investigate the time variability of our solution. A crack dipping 20° to the North-Northeast is reconcilable with all 15 tremor events. This mechanism is found to be constant for the entire length of each tremor and for different events

Post-tectonic landscape evolution in NE Iberia using staircase terraces: Combined effects of uplift and climate

© 2017 Elsevier B.V.River incision into bedrock resulting from the combined effects of tectonic uplift and climate governs long-term regional landscape evolution. We determined spatial and temporal patterns of post-orogenic stream incision from a sequence of well-preserved staircase terraces developed over the last 1 Ma in the Central Pyrenees and its southern foreland Ebro basin (NE Spain). Extensive remnants of ten vertically separated terraces (Qt1 to Qt10, from oldest to youngest) were mapped along 170 km of the Cinca River valley, transverse to the Pyrenean mountain belt. Multiple outcrops appear in the upper reach of the valley (Ainsa sector, 50 km from headwaters) as well as in the lower reach (Albalate sector, 125 km from headwaters). Fluvial incision into bedrock was calculated using (i) differentially corrected GPS measurements of the altitude of straths and (ii) numerical dating of alluvial sediments from the lower terraces (Qt5 to Qt9) by Optically Stimulated Luminescence, previously reported by Lewis et al. (2009), and supplemented with new dates for the upper terraces (Qt1, Qt2 and Qt3) based on paleomagnetism and supported by soil development. Considering altitude differences and the elapsed time between successive well preserved terrace couples (Qt3–Qt7, Qt7–Qt9 and Qt9-Active channel), mean bedrock incision rates ranged from 0.76 to 0.38 m ka− 1, at the upper reach of the valley (Ainsa section), and from 0.61 to 0.20 m ka− 1, at the lower reach (Albalate section). River incision along the valley produced vertically separated, near-parallel longitudinal terrace profiles evidencing a rapid near-uniform regional uplift as response to (i) the tectonic lithospheric thickening in NE Iberia and (ii) the erosional download rebound related to the Ebro basin exorheism. Moreover, a subtle upstream divergence of strath profiles may have been a consequence of an increase in uplift rate toward the head of the valley. Additionally, incision rates changed over time as indicate results from the lower reach (Albalate section); the maximum rate was 1.48 m ka− 1 between Qt7 (61 ka) and Qt8 (47 ka), and the minimum rate was 0.11 m ka− 1 between Qt3 (401 ka) and Qt5 (178 ka). The highest incision rates were produced after the Marine Isotope Stage 4 most likely in response to (i) an increased snowmelt discharge during the subsequent deglaciation related to the last maximum advance of glaciers in the southern Pyrenees, and (ii) a limited width of the valley after Qt7 formation, resulting from the deactivation of the westward river migration. Therefore, incision rates over the last 1 Ma in the Cinca River valley were basically controlled by near-uniform bedrock uplift, in the context of climate variability. The results reported in this study represent significant data on fluvial incision in NE Iberia, and provide an assessment of the regional post-tectonic landscape evolution

Weaker HLA footprints on HIV in the unique and highly genetically admixed host population of Mexico

HIV circumvents HLA class I-restricted CD8+ T-cell responses through selection of escape mutations that leave characteristic mutational “footprints,” also known as HLA-associated polymorphisms (HAPs), on HIV sequences at the population level. While many HLA footprints are universal across HIV subtypes and human populations, others can be region specific as a result of the unique immunogenetic background of each host population. Using a published probabilistic phylogenetically informed model, we compared HAPs in HIV Gag and Pol (PR-RT) in 1,612 subtype B-infected, antiretroviral treatment-naive individuals from Mexico and 1,641 individuals from Canada/United States. A total of 252 HLA class I allele subtypes were represented, including 140 observed in both cohorts, 67 unique to Mexico, and 45 unique to Canada/United States. At the predefined statistical threshold of a q value of <0.2, 358 HAPs (201 in Gag, 157 in PR-RT) were identified in Mexico, while 905 (534 in Gag and 371 in PR-RT) were identified in Canada/United States. HAPs identified in Mexico included both canonical HLA-associated escape pathways and novel associations, in particular with HLA alleles enriched in Amerindian and mestizo populations. Remarkably, HLA footprints on HIV in Mexico were not only fewer but also, on average, significantly weaker than those in Canada/United States, although some exceptions were noted. Moreover, exploratory analyses suggested that the weaker HLA footprint on HIV in Mexico may be due, at least in part, to weaker and/or less reproducible HLA-mediated immune pressures on HIV in this population. The implications of these differences for natural and vaccine-induced anti-HIV immunity merit further investigation

Effectiveness of rosuvastatin plus colchicine, emtricitabine/tenofovir and combinations thereof in hospitalized patients with COVID-19 : a pragmatic, open-label randomized trial

Q1Q1The use of rosuvastatin plus colchicine and emtricitabine/tenofovir in hospitalized patients with SARS- CoV-2 disease (COVID-19) has not been assessed. The objective of this study was to assess the effectiveness and safety of rosuvastatin plus colchicine, emtricitabine/tenofovir, and their combined use in these patients.Revista Internacional - Indexad

Cost-effectiveness of a multitarget stool DNA test for colorectal cancer screening of Medicare beneficiaries

Background In 2014, the Centers for Medicare and Medicaid Services (CMS) began covering a multitarget stool DNA (mtSDNA) test for colorectal cancer (CRC) screening of Medicare beneficiaries. In this study, we evaluate

Molecules with ALMA at planet-forming scales (MAPS). IV. Emission surfaces and vertical distribution of molecules

The Molecules with ALMA at Planet-forming Scales (MAPS) Large Program provides a unique opportunity to study the vertical distribution of gas, chemistry, and temperature in the protoplanetary disks around IM Lup, GM Aur, AS 209, HD 163296, and MWC 480. By using the asymmetry of molecular line emission relative to the disk major axis, we infer the emission height (z) above the midplane as a function of radius (r). Using this method, we measure emitting surfaces for a suite of CO isotopologues, HCN, and C2H. We find that 12CO emission traces the most elevated regions with z/r > 0.3, while emission from the less abundant 13CO and C18O probes deeper into the disk at altitudes of z/r ≲ 0.2. C2H and HCN have lower opacities and signal-to-noise ratios, making surface fitting more difficult, and could only be reliably constrained in AS 209, HD 163296, and MWC 480, with z/r ≲ 0.1, i.e., relatively close to the planet-forming midplanes. We determine peak brightness temperatures of the optically thick CO isotopologues and use these to trace 2D disk temperature structures. Several CO temperature profiles and emission surfaces show dips in temperature or vertical height, some of which are associated with gaps and rings in line and/or continuum emission. These substructures may be due to local changes in CO column density, gas surface density, or gas temperatures, and detailed thermochemical models are necessary to better constrain their origins and relate the chemical compositions of elevated disk layers with those of planet-forming material in disk midplanes. This paper is part of the MAPS special issue of the Astrophysical Journal Supplement. © 2021. The American Astronomical Society. All rights reserved.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Volume I. Introduction to DUNE

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE\u27s physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology