586 research outputs found
Reviews
Web‐Teaching ‐ A Guide to Interactive Teaching for the World‐Wide Web by David W. Brooks, New York: Plenum, 1997. ISBN: 0–306–45552–8. Paperback, 214 pages. $30
Effect of early adversity and childhood internalizing symptoms on brain structure in young men
- Importance: Early adversity is an important risk factor that relates to internalizing symptoms and altered brain structure.
- Objective: To assess the direct effects of early adversity and child internalizing symptoms (ie, depression, anxiety) on cortical gray matter (GM) volume, as well as the extent to which early adversity associates with variation in cortical GM volume indirectly via increased levels of internalizing symptoms.
- Design, Setting, and Participants: A prospective investigation of associations between adversity within the first 6 years of life, internalizing symptoms during childhood and early adolescence, and altered brain structure in late adolescence (age, 18-21 years) was conducted in a community-based birth cohort in England (Avon Longitudinal Study of Parents and Children). Participants from the cohort included 494 mother-son pairs monitored since the mothers were pregnant (estimated date of delivery between April 1, 1991, and December 31, 1992). Data collection for the present study was conducted between April 1, 1991, and November 30, 2010; the neuroimaging data were collected between September 1, 2010, and November 30, 2012, and data analyses for the present study occurred between January 25, 2013, and February 15, 2015. Risk factors were adversity within the first 6 years of the child’s life (including prenatal exposure) and the child’s internalizing symptoms between age 7 and 13 years.
- Exposures: Early childhood adversity.
- Main Outcomes and Measures: The main outcome was GM volume of cortical regions previously associated with major depression measured through T1-weighted magnetic resonance images collected in late adolescence.
- Results: Among 494 young men included in this analysis, early adversity was directly associated with lower GM volumes in the anterior cingulate cortex (β = −.18; P = .01) and higher GM volume in the precuneus (β = .18; P = .009). Childhood internalizing symptoms were associated with lower GM volume in the right superior frontal gyrus (β = −.20; P = .002). Early adversity was also associated with higher levels of internalizing symptoms (β = .37; P < .001), which, in turn, were associated with lower superior frontal gyrus volume (ie, an indirect effect) (β = −.08; 95% CI, −0.14 to −0.01; P = .02).
- Conclusions and Relevance: Adversity early in life was associated with higher levels of internalizing symptoms as well as with altered brain structure. Early adversity was related to variation in brain structure both directly and via increased levels of internalizing symptoms. These findings may suggest that some of the structural variation often attributed to depression might be associated with early adversity in addition to the effect of depression
An Equation of State of a Carbon-Fibre Epoxy Composite under Shock Loading
An anisotropic equation of state (EOS) is proposed for the accurate
extrapolation of high-pressure shock Hugoniot (anisotropic and isotropic)
states to other thermodynamic (anisotropic and isotropic) states for a shocked
carbon-fibre epoxy composite (CFC) of any symmetry. The proposed EOS, using a
generalised decomposition of a stress tensor [Int. J. Plasticity \textbf{24},
140 (2008)], represents a mathematical and physical generalisation of the
Mie-Gr\"{u}neisen EOS for isotropic material and reduces to this equation in
the limit of isotropy. Although a linear relation between the generalised
anisotropic bulk shock velocity and particle velocity was
adequate in the through-thickness orientation, damage softening process
produces discontinuities both in value and slope in the -
relation. Therefore, the two-wave structure (non-linear anisotropic and
isotropic elastic waves) that accompanies damage softening process was proposed
for describing CFC behaviour under shock loading. The linear relationship
- over the range of measurements corresponding to non-linear
anisotropic elastic wave shows a value of (the intercept of the
- curve) that is in the range between first and second
generalised anisotropic bulk speed of sound [Eur. Phys. J. B \textbf{64}, 159
(2008)]. An analytical calculation showed that Hugoniot Stress Levels (HELs) in
different directions for a CFC composite subject to the two-wave structure
(non-linear anisotropic elastic and isotropic elastic waves) agree with
experimental measurements at low and at high shock intensities. The results are
presented, discussed and future studies are outlined.Comment: 12 pages, 9 figure
New Upper Limit of Terrestrial Equivalence Principle Test for Rotating Extended Bodies
Improved terrestrial experiment to test the equivalence principle for
rotating extended bodies is presented, and a new upper limit for the violation
of the equivalence principle is obtained at the level of 1.6, which is limited by the friction of the rotating gyroscope. It
means the spin-gravity interaction between the extended bodies has not been
observed at this level.Comment: 4 page
Modulational Instability in Equations of KdV Type
It is a matter of experience that nonlinear waves in dispersive media,
propagating primarily in one direction, may appear periodic in small space and
time scales, but their characteristics --- amplitude, phase, wave number, etc.
--- slowly vary in large space and time scales. In the 1970's, Whitham
developed an asymptotic (WKB) method to study the effects of small
"modulations" on nonlinear periodic wave trains. Since then, there has been a
great deal of work aiming at rigorously justifying the predictions from
Whitham's formal theory. We discuss recent advances in the mathematical
understanding of the dynamics, in particular, the instability of slowly
modulated wave trains for nonlinear dispersive equations of KdV type.Comment: 40 pages. To appear in upcoming title in Lecture Notes in Physic
Progress in operational modeling in support of oil spill response
Following the 2010 Deepwater Horizon accident of a massive blow-out in the Gulf of Mexico, scientists from government, industry, and academia collaborated to advance oil spill modeling and share best practices in model algorithms, parameterizations, and application protocols. This synergy was greatly enhanced by research funded under the Gulf of Mexico Research Initiative (GoMRI), a 10-year enterprise that allowed unprecedented collection of observations and data products, novel experiments, and international collaborations that focused on the Gulf of Mexico, but resulted in the generation of scientific findings and tools of broader value. Operational oil spill modeling greatly benefited from research during the GoMRI decade. This paper provides a comprehensive synthesis of the related scientific advances, remaining challenges, and future outlook. Two main modeling components are discussed: Ocean circulation and oil spill models, to provide details on all attributes that contribute to the success and limitations of the integrated oil spill forecasts. These forecasts are discussed in tandem with uncertainty factors and methods to mitigate them. The paper focuses on operational aspects of oil spill modeling and forecasting, including examples of international operational center practices, observational needs, communication protocols, and promising new methodologies
Environmental monitoring : phase 5 final report (April 2019 - March 2020)
This report presents the results and interpretation for Phase 5 of an integrated environmental
monitoring programme that is being undertaken around two proposed shale gas sites in England –
Preston New Road, Lancashire and Kirby Misperton, North Yorkshire. The report should be read
in conjunction with previous reports freely available through the project website1
. These provide
additional background to the project, presentation of earlier results and the rationale for
establishment of the different elements of the monitoring programme
Detector Description and Performance for the First Coincidence Observations between LIGO and GEO
For 17 days in August and September 2002, the LIGO and GEO interferometer
gravitational wave detectors were operated in coincidence to produce their
first data for scientific analysis. Although the detectors were still far from
their design sensitivity levels, the data can be used to place better upper
limits on the flux of gravitational waves incident on the earth than previous
direct measurements. This paper describes the instruments and the data in some
detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial
change
Search for Gravitational Waves from Primordial Black Hole Binary Coalescences in the Galactic Halo
We use data from the second science run of the LIGO gravitational-wave
detectors to search for the gravitational waves from primordial black hole
(PBH) binary coalescence with component masses in the range 0.2--.
The analysis requires a signal to be found in the data from both LIGO
observatories, according to a set of coincidence criteria. No inspiral signals
were found. Assuming a spherical halo with core radius 5 kpc extending to 50
kpc containing non-spinning black holes with masses in the range 0.2--, we place an observational upper limit on the rate of PBH coalescence
of 63 per year per Milky Way halo (MWH) with 90% confidence.Comment: 7 pages, 4 figures, to be submitted to Phys. Rev.
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