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Reactive Halogens in the Marine Boundary Layer (RHaMBLe): The tropical North Atlantic experiments
The NERC UK SOLAS-funded Reactive Halogens in the Marine Boundary Layer (RHaMBLe) programme comprised three field experiments. This manuscript presents an overview of the measurements made within the two simultaneous remote experiments conducted in the tropical North Atlantic in May and June 2007. Measurements were made from two mobile and one ground-based platforms. The heavily instrumented cruise D319 on the RRS Discovery from Lisbon, Portugal to São Vicente, Cape Verde and back to Falmouth, UK was used to characterise the spatial distribution of boundary layer components likely to play a role in reactive halogen chemistry. Measurements onboard the ARSF Dornier aircraft were used to allow the observations to be interpreted in the context of their vertical distribution and to confirm the interpretation of atmospheric structure in the vicinity of the Cape Verde islands. Long-term ground-based measurements at the Cape Verde Atmospheric Observatory (CVAO) on São Vicente were supplemented by long-term measurements of reactive halogen species and characterisation of additional trace gas and aerosol species during the intensive experimental period.
This paper presents a summary of the measurements made within the RHaMBLe remote experiments and discusses them in their meteorological and chemical context as determined from these three platforms and from additional meteorological analyses. Air always arrived at the CVAO from the North East with a range of air mass origins (European, Atlantic and North American continental). Trace gases were present at stable and fairly low concentrations with the exception of a slight increase in some anthropogenic components in air of North American origin, though NOx mixing ratios during this period remained below 20 pptv (note the non-IUPAC adoption in this manuscript of pptv and ppbv, equivalent to pmol mol−1 and nmol mol−1 to reflect common practice). Consistency with these air mass classifications is observed in the time series of soluble gas and aerosol composition measurements, with additional identification of periods of slightly elevated dust concentrations consistent with the trajectories passing over the African continent. The CVAO is shown to be broadly representative of the wider North Atlantic marine boundary layer; measurements of NO, O3 and black carbon from the ship are consistent with a clean Northern Hemisphere marine background. Aerosol composition measurements do not indicate elevated organic material associated with clean marine air. Closer to the African coast, black carbon and NO levels start to increase, indicating greater anthropogenic influence. Lower ozone in this region is possibly associated with the increased levels of measured halocarbons, associated with the nutrient rich waters of the Mauritanian upwelling. Bromide and chloride deficits in coarse mode aerosol at both the CVAO and on D319 and the continuous abundance of inorganic gaseous halogen species at CVAO indicate significant reactive cycling of halogens.
Aircraft measurements of O3 and CO show that surface measurements are representative of the entire boundary layer in the vicinity both in diurnal variability and absolute levels. Above the inversion layer similar diurnal behaviour in O3 and CO is observed at lower mixing ratios in the air that had originated from south of Cape Verde, possibly from within the ITCZ. ECMWF calculations on two days indicate very different boundary layer depths and aircraft flights over the ship replicate this, giving confidence in the calculated boundary layer depth
The PanCam Instrument for the ExoMars Rover
The scientific objectives of the ExoMars rover are designed to answer several key questions in the search for life on Mars. In particular, the unique subsurface drill will address some of these, such as the possible existence and stability of subsurface organics. PanCam will establish the surface geological and morphological context for the mission, working in collaboration with other context instruments. Here, we describe the PanCam scientific objectives in geology, atmospheric science, and 3-D vision. We discuss the design of PanCam, which includes a stereo pair of Wide Angle Cameras (WACs), each of which has an 11-position filter wheel and a High Resolution Camera (HRC) for high-resolution investigations of rock texture at a distance. The cameras and electronics are housed in an optical bench that provides the mechanical interface to the rover mast and a planetary protection barrier. The electronic interface is via the PanCam Interface Unit (PIU), and power conditioning is via a DC-DC converter. PanCam also includes a calibration target mounted on the rover deck for radiometric calibration, fiducial markers for geometric calibration, and a rover inspection mirror.publishersversionPeer reviewe
Effects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs
Alcohol Use Among Young Adolescents in Belgium, the Netherlands, Germany and Austria: The Effects of Type of Education
TOI-811b and TOI-852b: New transiting brown dwarfs with similar masses and very different radii and ages from the TESS mission
We report the discovery of two transiting brown dwarfs (BDs), TOI-811b and TOI-852b, from NASA's Transiting Exoplanet Survey Satellite mission. These two transiting BDs have similar masses but very different radii and ages. Their host stars have similar masses, effective temperatures, and metallicities. The younger and larger transiting BD is TOI-811b at a mass of Mb = 59.9 ± 13.0MJ and radius of Rb = 1.26 ± 0.06RJ, and it orbits its host star in a period of P = 25.16551 ± 0.00004 days. We derive the host star's age of 93+61-29 Myr from an application of gyrochronology. The youth of this system, rather than external heating from its host star, is why this BD's radius is relatively large. This constraint on the youth of TOI-811b allows us to test substellar mass-radius evolutionary models at young ages where the radius of BDs changes rapidly. TOI-852b has a similar mass at Mb = 53.7 ± 1.4MJ but is much older (4 or 8 Gyr, based on bimodal isochrone results of the host star) and is also smaller with a radius of Rb = 0.83 ± 0.04RJ. TOI-852b's orbital period is P = 4.94561 ± 0.00008 days. TOI-852b joins the likes of other old transiting BDs that trace out the oldest substellar mass-radius evolutionary models where contraction of the BD's radius slows and approaches a constant value. Both host stars have a mass of M∗ = 1.32M⊙ ± 0.05 and differ in their radii, Teff, and [Fe/H], with TOI-811 having R∗ = 1.27 ± 0.09R⊙, Teff = 6107 ± 77 K, and [Fe/ H]=+0.40 ± 0.09 and TOI-852 having R∗ = 1.71 ± 0.04R⊙, Teff = 5768 ± 84 K, and [Fe/H]=+0.33 ± 0.09. We take this opportunity to examine how TOI-811b and TOI-852b serve as test points for young and old substellar isochrones, respectively
Two Young Planetary Systems around Field Stars with Ages between 20 and 320 Myr from TESS
Planets around young stars trace the early evolution of planetary systems. We report the discovery and validation of two planetary systems with ages <∼300Myr from observations by the Transiting Exoplanet Survey Satellite (TESS). The 40 V320 Myr old G star TOI-251 hosts a 2.74+0.18-0.18 mini-Neptune with a 4.94 day period. The 20-160 Myr old K star TOI-942 hosts a system of inflated Neptune-sized planets, with TOI-942b orbiting in a period of 4.32 days with a radius of 4.81+0.20-0.20 and TOI-942c orbiting in a period of 10.16 days with a radius of 5.79-0.18+0.19 Though we cannot place either host star into a known stellar association or cluster, we can estimate their ages via their photometric and spectroscopic properties. Both stars exhibit significant photometric variability due to spot modulation, with measured rotation periods of .3.5 days. These stars also exhibit significant chromospheric activity, with age estimates from the chromospheric calcium emission lines and X-ray fluxes matching that estimated from gyrochronology. Both stars also exhibit significant lithium absorption, similar in equivalent width to well-characterized young cluster members. TESS has the potential to deliver a population of young planet-bearing field stars, contributing significantly to tracing the properties of planets as a function of their age
The LHS 1678 System: Two Earth-sized Transiting Planets and an Astrometric Companion Orbiting an M Dwarf Near the Convective Boundary at 20 pc
We present the Transiting Exoplanet Survey Satellite (TESS) discovery of the LHS 1678 (TOI-696) exoplanet system, comprised of two approximately Earth-sized transiting planets and a likely astrometric brown dwarf orbiting a bright (V J = 12.5, K s = 8.3) M2 dwarf at 19.9 pc. The two TESS-detected planets are of radius 0.70 ± 0.04 R ⊕ and 0.98 ± 0.06 R ⊕ in 0.86 day and 3.69 day orbits, respectively. Both planets are validated and characterized via ground-based follow-up observations. High Accuracy Radial Velocity Planet Searcher RV monitoring yields 97.7 percentile mass upper limits of 0.35 M ⊕ and 1.4 M ⊕ for planets b and c, respectively. The astrometric companion detected by the Cerro Tololo Inter-American Observatory/Small and Moderate Aperture Telescope System 0.9 m has an orbital period on the order of decades and is undetected by other means. Additional ground-based observations constrain the companion to being a high-mass brown dwarf or smaller. Each planet is of unique interest; the inner planet has an ultra-short period, and the outer planet is in the Venus zone. Both are promising targets for atmospheric characterization with the James Webb Space Telescope and mass measurements via extreme-precision radial velocity. A third planet candidate of radius 0.9 ± 0.1 R ⊕ in a 4.97 day orbit is also identified in multicycle TESS data for validation in future work. The host star is associated with an observed gap in the lower main sequence of the Hertzsprung-Russell diagram. This gap is tied to the transition from partially to fully convective interiors in M dwarfs, and the effect of the associated stellar astrophysics on exoplanet evolution is currently unknown. The culmination of these system properties makes LHS 1678 a unique, compelling playground for comparative exoplanet science and understanding the formation and evolution of small, short-period exoplanets orbiting low-mass stars
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
Background Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD.
Methods This large retrospective multicentre study compared cross-sectional CSF NfL levels of 162 patients with SD with 65 controls. CSF NfL levels of patients were correlated with clinical parameters (including survival), neuropsychological test scores and regional grey matter atrophy (including longitudinal data in a subset).
Results CSF NfL levels were significantly higher in patients with SD (median: 2326\u2009pg/mL, IQR: 1628\u20133593) than in controls (577 (446\u2013766), p<0.001). Higher CSF NfL levels were moderately associated with naming impairment as measured by the Boston Naming Test (rs = 120.32, p=0.002) and with smaller grey matter volume of the parahippocampal gyri (rs = 120.31, p=0.004). However, cross-sectional CSF NfL levels were not associated with progression of grey matter atrophy and did not predict survival.
Conclusion CSF NfL is a promising biomarker in the diagnostic process of SD, although it has limited cross-sectional monitoring or prognostic abilities
TESS discovery of a super-earth and three sub-neptunes hosted by the bright, sunlike star HD 108236
We report the discovery and validation of four extrasolar planets hosted by the nearby, bright, Sun-like (G3V) star HD 108236 using data from the Transiting Exoplanet Survey Satellite (TESS). We present transit photometry, reconnaissance, and precise Doppler spectroscopy, as well as high-resolution imaging, to validate the planetary nature of the objects transiting HD 108236, also known as the TESS Object of Interest (TOI) 1233. The innermost planet is a possibly rocky super-Earth with a period of 3.79523+0.00047-0.00044 days and has a radius of 1.586 ± 0.098 R⊗.The outer planets are sub-Neptunes, with potential gaseous envelopes, having radii of 2.068+0.10-0.091 R⊗, 2.72 ± 0.11 R⊗, and 3.12+0.13-0.12 R⊗ and periods of 6.20370+0.00064-0.00052 days, 14.17555+0.00099-0.0011 days, and 19.5917+0.0022-0.0020 days, respectively. With V and Ks magnitudes of 9.2 and 7.6, respectively, the bright host star makes the transiting planets favorable targets for mass measurements and, potentially, for atmospheric characterization via transmission spectroscopy. HD 108236 is the brightest Sun-like star in the visual (V ) band known to host four or more transiting exoplanets. The discovered planets span a broad range of planetary radii and equilibrium temperatures and share a common history of insolation from a Sun-like star (R∗ = 0.888 ± 0.017 R⊙, Teff = 5730 ± 50 K), making HD 108236 an exciting, opportune cosmic laboratory for testing models of planet formation and evolution
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