2,657 research outputs found
Study of f_0(980) and f_0(1500) from B_s \to f_0(980)\pi, f_0(1500)\pi Decays
In this paper, we analyze the scalar mesons and from
the decays within Perturbative
QCD approach. From the leading order calculations, we find that (a) in the
allowed mixing angle ranges, the branching ratio of is about , which is smaller than
that of (the difference is a few times even one
order); (b) the decay is better to distinguish
between the lowest lying state or the first excited state for ,
because the branching ratios for two scenarios have about one-order difference
in most of the mixing angle ranges; and (c) the direct CP asymmetries of for two scenarios also exists great difference. In
scenario II, the variation range of the value according to the mixing angle is very small, except for
the values corresponding to the mixing angles being near or
, while the variation range of in scenario I is very large. Compared with the future data for
the decay , it is ease to determine the nature
of the scalar meson .Comment: 16 pages, 3 figures, Revte
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility
Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genes’ influence on the attack mechanism of RA, early diagnosis and treatment of RA.Толл-подобные рецепторы (TLRs) играют важную роль в индукции и регуляции врожденной иммунной системы или адаптивных иммунных ответах. Показано, что что генетическая изменчивость TLRs человека связана с ревматоидным артритом (РА). Целью настоящей работы было изучение корреляций между однонуклеотидным полиморфизмом в сигнальной трансдукции TLRs и генами предрасположенности к РА. G-тип IL-1RAP rs766442 могут быть генами, предохраняющими от РА, в то время как аллели T-типа IL-6R rs11265618 и IL-1RAP rs766442 могут быть генами чувствительности к РА. Изучение полиморфизма нуклеиновых кислот в сигнальном пути TLRs может внести вклад в выявление участия генов в механизмах приступов РА, раннюю диагностику и лечение РА.The study was supported by Shandong Province young scientist in incentive fund (Grant № 2006BS03018) and National Natural Science Foundation of China (Grant № 30801025)
Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
Scope
In vitro and in vivo studies suggest that dietary anthocyanins modulate cardiovascular disease risk; however, given anthocyanins extensive metabolism, it is likely that their degradation products and conjugated metabolites are responsible for this reported bioactivity.
Methods and results
Human vascular endothelial cells were stimulated with either oxidized LDL (oxLDL) or cluster of differentiation 40 ligand (CD40L) and cotreated with cyanidin-3-glucoside and 11 of its recently identified metabolites, at 0.1, 1, and 10 μM concentrations. Protein and gene expression of IL-6 and VCAM-1 was quantified by ELISA and RT-qPCR. In oxLDL-stimulated cells the parent anthocyanin had no effect on IL-6 production, whereas numerous anthocyanin metabolites significantly reduced IL-6 protein levels; phase II conjugates of protocatechuic acid produced the greatest effects (>75% reduction, p ≤ 0.05). In CD40L-stimulated cells the anthocyanin and its phase II metabolites reduced IL-6 protein production, where protocatechuic acid-4-sulfate induced the greatest reduction (>96% reduction, p ≤ 0.03). Similarly, the anthocyanin and its metabolites reduced VCAM-1 protein production, with ferulic acid producing the greatest effect (>65% reduction, p ≤ 0.04).
Conclusion
These novel data provide evidence to suggest that anthocyanin metabolites are bioactive at physiologically relevant concentrations and have the potential to modulate cardiovascular disease progression by altering the expression of inflammatory mediators
Algebraic varieties with automorphism groups of maximal rank
We confirm, to some extent, the belief that a projective variety X has the
largest number (relative to the dimension of X) of independent commuting
automorphisms of positive entropy only when X is birational to a complex torus
or a quotient of a torus. We also include an addendum to an early paper though
it is not used in the present paper.Comment: Mathematische Annalen (to appear
Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells
Scope
The physiological relevance of contemporary cell culture studies is often perplexing, given the use of unmetabolized phytochemicals at supraphysiological concentrations. We investigated the activity of physiologically relevant anthocyanin metabolite signatures, derived from a previous pharmacokinetics study of 500 mg 13C5-cyanidin-3-glucoside in 8 healthy participants, on soluble vascular adhesion molecule-1 (VCAM-1) and interleukin-6 (IL-6) in human endothelial cells.
Methods and results
Signatures of peak metabolites (previously identified at 1, 6 and 24 h post-bolus) were reproduced using pure standards and effects were investigated across concentrations ten-fold lower and higher than observed mean (<5 μM) serum levels. Tumor necrosis factor-α (TNF-α)-stimulated VCAM-1 was reduced in response to all treatments, with maximal effects observed for the 6 h and 24 h profiles. Profiles tested at ten-fold below mean serum concentrations (0.19-0.44 μM) remained active. IL-6 was reduced in response to 1, 6 and 24 h profiles, with maximal effects observed for 6 h and 24 h profiles at concentrations above 2 μM. Protein responses were reflected by reductions in VCAM-1 and IL-6 mRNA, however there was no effect on phosphorylated NFκB-p65 expression.
Conclusion
Signatures of anthocyanin metabolites following dietary consumption reduce VCAM-1 and IL-6 production, providing evidence of physiologically relevant biological activity
On the Quantization of the Abelian Chern-Simons Coefficient at Finite Temperature
We show that when the Abelian \CS\ theory coupled to matter fields is
quantized in a vacuum with non vanishing magnetic flux (or electric charge),
the requirement of gauge invariance at finite temperature leads to the
quantization of the \CS\ coefficient and its quantum corrections, in a manner
similar to the non-Abelian case.Comment: 11 pages, LaTeX, no figures, no special macros. Some discussion and
references added. A minor error corrected. Final version to appear in Phys.
Lett.
Revisiting the B {\to} {\pi} {\rho}, {\pi} {\omega} Decays in the Perturbative QCD Approach Beyond the Leading Order
We calculate the branching ratios and CP asymmetries of the ,
decays in the perturbative QCD factorization approach up to the
next-to-leading-order contributions. We find that the next-to-leading-order
contributions can interfere with the leading-order part constructively or
destructively for different decay modes. Our numerical results have a much
better agreement with current available data than previous leading-order
calculations, e.g., the next-to-leading-order corrections enhance the
branching ratios by a factor 2.5, which is helpful
to narrow the gaps between theoretic predictions and experimental data. We also
update the direct CP-violation parameters, the mixing-induced CP-violation
parameters of these modes, which show a better agreement with experimental data
than many of the other approaches.Comment: 23 pages, 4 figures, 4 table
Many-body-QED perturbation theory: Connection to the Bethe-Salpeter equation
The connection between many-body theory (MBPT)--in perturbative and
non-perturbative form--and quantum-electrodynamics (QED) is reviewed for
systems of two fermions in an external field. The treatment is mainly based
upon the recently developed covariant-evolution-operator method for QED
calculations [Lindgren et al. Phys. Rep. 389, 161 (2004)], which has a
structure quite akin to that of many-body perturbation theory. At the same time
this procedure is closely connected to the S-matrix and the Green's-function
formalisms and can therefore serve as a bridge between various approaches. It
is demonstrated that the MBPT-QED scheme, when carried to all orders, leads to
a Schroedinger-like equation, equivalent to the Bethe-Salpeter (BS) equation. A
Bloch equation in commutator form that can be used for an "extended" or
quasi-degenerate model space is derived. It has the same relation to the BS
equation as has the standard Bloch equation to the ordinary Schroedinger
equation and can be used to generate a perturbation expansion compatible with
the BS equation also for a quasi-degenerate model space.Comment: Submitted to Canadian J of Physic
Pairing Correlations in a Generalized Hubbard Model for the Cuprates
Using numerical diagonalization of a 4x4 cluster, we calculate on-site s,
extended s and d pairing correlation functions (PCF) in an effective
generalized Hubbard model for the cuprates, with nearest-neighbor correlated
hopping and next nearest-neighbor hopping t'. The vertex contributions (VC) to
the PCF are significantly enhanced, relative to the t-t'-U model. The behavior
of the PCF and their VC, and signatures of anomalous flux quantization,
indicate superconductivity in the d-wave channel for moderate doping and in the
s-wave channel for high doping and small U.Comment: 5 pages, 5 figure
Exact solutions of noncommutative vacuum Einstein field equations and plane-fronted gravitational waves
We construct a class of exact solutions of the noncommutative vacuum Einstein
field equations, which are noncommutative analogues of the plane-fronted
gravitational waves in classical gravity.Comment: 10 pages, comments adde
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