9,291 research outputs found
Coexisting conical bipolar and equatorial outflows from a high-mass protostar
The BN/KL region in the Orion molecular cloud is an archetype in the study of
the formation of stars much more massive than the Sun. This region contains
luminous young stars and protostars, but it is difficult to study because of
overlying dust and gas. Our basic expectations are shaped to some extent by the
present theoretical picture of star formation, the cornerstone of which is that
protostars acrete gas from rotating equatorial disks, and shed angular momentum
by ejecting gas in bipolar outflows. The main source of the outflow in the
BN/KL region may be an object known as radio source I, which is commonly
believed to be surrounded by a rotating disk of molecular material. Here we
report high-resolution observations of silicon monoxide (SiO) and water maser
emission from the gas surrounding source I; we show that within 60 AU (about
the size of the Solar System), the region is dominated by a conical bipolar
outflow, rather than the expected disk. A slower outflow, close to the
equatorial plane of the protostellar system, extends to radii of 1,000 AU.Comment: 10 pages, 2 figures. Accepted by Nature. To appear December 199
Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.
The cellular effects of numerous hormones and neurotransmitters, including the vasoactive agents angiotensin II (AngII) and [Arg8]vasopressin, are mediated in part by protein-serine threonine kinases activated by increase of cytosolic Ca2+ concentration. In this study, we have tested the ability of Ca(2+)-mobilizing agents to activate cellular tyrosine kinases. Treatment of intact GN4 liver epithelial cells with AngII rapidly (less than or equal to 15 sec) increased tyrosine kinase activity measured either in unfractionated cell lysates or in anti-phosphotyrosine immune complexes from detergent-solubilized cells. Increased phosphorylation of the exogenous substrate poly(Glu80Tyr20) (3- to 4-fold over control) by immunoprecipitated kinases closely paralleled the time- and dose-dependence of the appearance of tyrosine phosphoproteins in intact cells. This effect of AngII was mimicked by thapsigargin, a Ca(2+)-elevating tumor promoter. The ability of AngII, but not epidermal growth factor, to increase tyrosine kinase activity was blocked in cells loaded with the Ca2+ chelator bis-(O-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid. Dephosphorylation of immunoprecipitated proteins by tyrosine phosphatase treatment was accompanied by a 60-70% loss in in vitro kinase activity, suggesting that the AngII-sensitive kinase(s) are activated by phosphorylation in intact cells. These findings demonstrate a link between two widely occurring signaling pathways, the tyrosine kinases and the Ca2+ second-messenger system, and suggest the possible involvement of Ca(2+)-activated tyrosine kinases in the endocrine actions of AngII and [Arg8]vasopressin
Update about OralairÂź as a treatment for grass pollen allergic rhinitis
Sublingual immunotherapy (SLIT) is a well-tolerated, safe, and effective approach to treating allergic rhinitis (AR). Oralair (R) is a five-grass pollen SLIT tablet containing natural pollen allergens from five of the major grass species responsible for seasonal AR due to grass pollen allergy. Recommended use is in a pre-coseasonal regimen, starting daily treatment approximately 4 months before the start of the pollen season, with treatment then continued daily throughout the season; treatment should continue for 3-5 y. Clinical efficacy and safety of Oralair (R) in patients with grass pollen-induced AR has been demonstrated in a comprehensive clinical development program of randomized controlled trials. Effectiveness has been substantiated in subsequent observational studies with sustained efficacy following treatment cessation and a favorable level of adherence, quality of life, benefit, and satisfaction for the patients. Supportive evidence for a benefit in reducing the risk or delaying the development of allergic asthma is emerging
The next-to-leading order forward jet vertex in the small-cone approximation
We consider within QCD collinear factorization the process p+p to jet + jet
+X, where two forward high- jets are produced with a large separation in
rapidity (Mueller-Navelet jets). In this case the (calculable) hard
part of the reaction receives large higher-order corrections , which can be accounted for in the BFKL approach. In particular,
we calculate in the next-to-leading order the impact factor (vertex) for the
production of a forward high- jet, in the approximation of small aperture
of the jet cone in the pseudorapidity-azimuthal angle plane. The final
expression for the vertex turns out to be simple and easy to implement in
numerical calculations.Comment: 32 pages, 4 figures; a few comments and one reference added; a few
inessential misprints removed; version to appear on JHE
Decadal changes of the Western Arabian sea ecosystem
Historical data from oceanographic expeditions and remotely sensed data on outgoing longwave radiation, temperature, wind speed and ocean color in the western Arabian Sea (1950â2010) were used to investigate decadal trends in the physical and biochemical properties of the upper 300 m. 72 % of the 29,043 vertical profiles retrieved originated from USA and UK expeditions. Increasing outgoing longwave radiation, surface air temperatures and sea surface temperature were identified on decadal timescales. These were well correlated with decreasing wind speeds associated with a reduced Siberian High atmospheric anomaly. Shoaling of the oxycline and nitracline was observed as well as acidification of the upper 300 m. These physical and chemical changes were accompanied by declining chlorophyll-a concentrations, vertical macrofaunal habitat compression, declining sardine landings and an increase of fish kill incidents along the Omani coast
On the stability of the exact solutions of the dual-phase lagging model of heat conduction
The dual-phase lagging (DPL) model has been considered as one of the most promising theoretical approaches to generalize the classical Fourier law for heat conduction involving short time and space scales. Its applicability, potential, equivalences, and possible drawbacks have been discussed in the current literature. In this study, the implications of solving the exact DPL model of heat conduction in a three-dimensional bounded domain solution are explored. Based on the principle of causality, it is shown that the temperature gradient must be always the cause and the heat flux must be the effect in the process of heat transfer under the dual-phase model. This fact establishes explicitly that the single- and DPL models with different physical origins are mathematically equivalent. In addition, taking into account the properties of the Lambert W function and by requiring that the temperature remains stable, in such a way that it does not go to infinity when the time increases, it is shown that the DPL model in its exact form cannot provide a general description of the heat conduction phenomena
Mice lacking NF-ÎșB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration
Tamoxifen (TAM) has recently been shown to cause acute gastric atrophy and metaplasia in mice. We have previously demonstrated that the outcome of Helicobacter felis infection, which induces similar gastric lesions in mice, is altered by deletion of specific NF-ÎșB subunits. Nfkb1-/- mice developed more severe gastric atrophy than wild-type (WT) mice 6 weeks after H. felis infection. In contrast, Nfkb2-/- mice were protected from this pathology. We therefore hypothesized that gastric lesions induced by TAM may be similarly regulated by signaling via NF-ÎșB subunits. Groups of five female C57BL/6 (WT), Nfkb1-/-, Nfkb2-/- and c-Rel-/- mice were administered 150âmg/kg TAM by IP injection. Seventy-two hours later, gastric corpus tissues were taken for quantitative histological assessment. In addition, groups of six female WT and Nfkb1-/- mice were exposed to 12âGy Îł-irradiation. Gastric epithelial apoptosis was quantified 6 and 48âh after irradiation. TAM induced gastric epithelial lesions in all strains of mice, but this was more severe in Nfkb1-/- mice than in WT mice. Nfkb1-/- mice exhibited more severe parietal cell loss than WT mice, had increased gastric epithelial expression of Ki67 and had an exaggerated gastric epithelial DNA damage response as quantified by ÎłH2AX. To investigate whether the difference in gastric epithelial DNA damage response of Nfkb1-/- mice was unique to TAM-induced DNA damage or a generic consequence of DNA damage, we also assessed gastric epithelial apoptosis following Îł-irradiation. Six hours after Îł-irradiation, gastric epithelial apoptosis was increased in the gastric corpus and antrum of Nfkb1-/- mice. NF-ÎșB1-mediated signaling regulates the development of gastric mucosal pathology following TAM administration. This is associated with an exaggerated gastric epithelial DNA damage response. This aberrant response appears to reflect a more generic sensitization of the gastric mucosa of Nfkb1-/- mice to DNA damage
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMPTP) is a proposed IR phosphatase, yet its role in insulin signaling in vivo has not been defined. Here we show that global and liver-specific LMPTP deletion protects mice from high-fat diet-induced diabetes without affecting body weight. To examine the role of the catalytic activity of LMPTP, we developed a small-molecule inhibitor with a novel uncompetitive mechanism, a unique binding site at the opening of the catalytic pocket, and an exquisite selectivity over other phosphatases. This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes. Our findings suggest that LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes
Physics of Ultra-Peripheral Nuclear Collisions
Moving highly-charged ions carry strong electromagnetic fields that act as a
field of photons. In collisions at large impact parameters, hadronic
interactions are not possible, and the ions interact through photon-ion and
photon-photon collisions known as {\it ultra-peripheral collisions} (UPC).
Hadron colliders like the Relativistic Heavy Ion Collider (RHIC), the Tevatron
and the Large Hadron Collider (LHC) produce photonuclear and two-photon
interactions at luminosities and energies beyond that accessible elsewhere; the
LHC will reach a energy ten times that of the Hadron-Electron Ring
Accelerator (HERA). Reactions as diverse as the production of anti-hydrogen,
photoproduction of the , transmutation of lead into bismuth and
excitation of collective nuclear resonances have already been studied. At the
LHC, UPCs can study many types of `new physics.'Comment: 47 pages, to appear in Annual Review of Nuclear and Particle Scienc
The magic nature of 132Sn explored through the single-particle states of 133Sn
Atomic nuclei have a shell structure where nuclei with 'magic numbers' of
neutrons and protons are analogous to the noble gases in atomic physics. Only
ten nuclei with the standard magic numbers of both neutrons and protons have so
far been observed. The nuclear shell model is founded on the precept that
neutrons and protons can move as independent particles in orbitals with
discrete quantum numbers, subject to a mean field generated by all the other
nucleons. Knowledge of the properties of single-particle states outside nuclear
shell closures in exotic nuclei is important for a fundamental understanding of
nuclear structure and nucleosynthesis (for example the r-process, which is
responsible for the production of about half of the heavy elements). However,
as a result of their short lifetimes, there is a paucity of knowledge about the
nature of single-particle states outside exotic doubly magic nuclei. Here we
measure the single-particle character of the levels in 133Sn that lie outside
the double shell closure present at the short-lived nucleus 132Sn. We use an
inverse kinematics technique that involves the transfer of a single nucleon to
the nucleus. The purity of the measured single-particle states clearly
illustrates the magic nature of 132Sn.Comment: 19 pages, 5 figures and 4 table
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