Design of a Novel Antenna Array Beamformer Using Neural Networks Trained by Modified Adaptive Dispersion Invasive Weed Optimization Based Data

A new antenna array beamformer based on neural networks (NNs) is presented. The NN training is performed by using optimized data sets extracted by a novel Invasive Weed Optimization (IWO) variant called Modified Adaptive Dispersion IWO (MADIWO). The trained NN is utilized as an adaptive beamformer that makes a uniform linear antenna array steer the main lobe towards a desired signal, place respective nulls towards several interference signals and suppress the side lobe level (SLL). Initially, the NN structure is selected by training several NNs of various structures using MADIWO based data and by making a comparison among the NNs in terms of training performance. The selected NN structure is then used to construct an adaptive beamformer, which is compared to MADIWO based and ADIWO based beamformers, regarding the SLL as well as the ability to properly steer the main lobe and the nulls. The comparison is made considering several sets of random cases with different numbers of interference signals and different power levels of additive zero-mean Gaussian noise. The comparative results exhibit the advantages of the proposed beamformer

High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men-San Francisco, California.

We estimate the relative transmission rate in early versus later infection among men who have sex with men (MSM) in San Francisco, California, by studying the characteristics of a sample of transmitters, recruited through newly diagnosed, recently infected MSM between 1996 and 2009. Of 36 transmitters identified, 9 were determined on the basis of testing history and serologic testing to have been recently infected. The unadjusted odds ratio of transmitting during early infection was 15.2 (95% confidence interval [CI], 6.3–33.4; P < .001); the odds ratio was 8.9 (95% CI, 4.1–19.4) after adjustment for self-reported antiretroviral treatment. This high transmissibility could be due to both high infectiousness and high rates of sex partner change or concurrent partnerships

Inverting multispectral thermal time-series images of volcanic eruptions for lava emplacement models

We present a novel method for interpreting time series of multispectral observations of volcanic eruptions. We show how existing models relating radiance and area emplacement can be generalised to an integration-convolution of a Net Area Emplacement (NAE) function and a cooling function, assuming all surfaces follow the same cooling curve. The NAE describes the variation in the rate of emplacement of hot material with time and temperature, while the cooling function describes the cooling of a hot surface with time. Discretizing the integration-convolution equation yields an underdetermined matrix equation that we solve using 2nd order Tikhonov regularization to stabilize the solution. We test the inversion by modelling plausible NAE surfaces, calculating the radiances, adding noise, and inverting for the original surface. Three or more spectral bands are required to capture the overall shape of the NAE, and recovering specific quantities is difficult. Single wavebands that yield flat kernels recover the total area emplacement curve (rate of increase of hot area – the integral of the NAE with respect to temperature) surprisingly well due to their property of conserving NAE, suggesting novel methods for calculating area emplacement rates (and effusion rates) from time series of satellite images and radiometer measurements.This research was undertaken as part of the NERC consortium project “How does the Earth's crust grow at divergent plate boundaries? A unique opportunity in Afar, Ethiopia” (grant number NE/E005535/1). CO is additionally supported by the National Centre for Earth Observation (COMET+).This is the final version of the article. It first appeared from the Geological Society via http://dx.doi.org/10.1144/SP426.1

Computation of thermochemical nonequilibrium flows around a simple and a double ellipse

The nonequilibrium viscous reactive flows over a simple and a double ellipse at a 30 degree angle of attack were computed. The geometry and the free stream conditions are given by INRIA/GAMNI/SMAI workshop test cases 6.2-2 and 6.2-4. The governing Navier-Stokes equations coupled with thermochemical nonequilibrium processes are solved numerically using a fully coupled, implicit, finite volume technique with a dynamically adaptive grid. The nonequilibrium gas model and the numerical method used in the calculations are briefly described

Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity.

Cognitive-behavioral therapy (CBT) is effective for obsessive compulsive disorder (OCD); however, little is understood about its mechanisms related to brain network connectivity. We examined connectivity changes from resting-state functional magnetic resonance imaging data pre-to-post-CBT in 43 OCD participants, randomized to receive either 4 weeks of intensive CBT or 4 weeks waitlist followed by 4 weeks of CBT, and 24 healthy controls before and after 4 weeks of no treatment. Network-based-statistic analysis revealed large-magnitude increases in OCD connectivity in eight networks. Strongest increases involved connectivity between the cerebellum and caudate/putamen, and between the cerebellum and dorsolateral/ventrolateral prefrontal cortices. Connectivity increases were associated with increased resistance to compulsions. Mechanisms of CBT may involve enhanced cross-network integration, both within and outside of classical cortico-striatal-thalamo-cortical regions; those involving cerebellar to striatal and prefrontal regions may reflect acquisition of new non-compulsive goal-directed behaviors and thought patterns. Our findings have implications for identifying targets for enhancing treatment efficacy and monitoring treatment progress

An Alternative Approach to Aldol Reactions: Gold-Catalyzed Formation of Boron Enolates from Alkynes

A new method for enolate generation via the gold-catalyzed addition of boronic acids to alkynes is reported. The formation of boron enolates from readily accessible ortho-alkynylbenzeneboronic acids proceeds rapidly with 2 mol % PPh3AuNTf2 at ambient temperature. The enolates undergo aldol reaction with an aldehyde present in the reaction mixture to give cyclic boronate esters, which can be subsequently transformed into phenols, biaryls, or dihydrobenzofurans via oxidation, Suzuki-Miyaura, or intramolecular Chan-Lam coupling, respectively. A combined gold/boronic acid catalyzed aldol condensation reaction of an alkynyl aldehyde was also successfully achieved

Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care.

BACKGROUND: Lower respiratory tract infections (LRTI) are a common reason for consulting general practitioners (GPs). In most cases the aetiology is unknown, yet most result in an antibiotic prescription. The aetiology of LRTI was investigated in a prospective controlled study. METHODS: Eighty adults presenting to GPs with acute LRTI were recruited together with 49 controls over 12 months. Throat swabs, nasal aspirates (patients and controls), and sputum (patients) were obtained and polymerase chain reaction (PCR) and reverse transcriptase polymerase chain reaction (RT-PCR) assays were used to detect Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella pneumophila, influenza viruses (AH1, AH3 and B), parainfluenza viruses 1-3, coronaviruses, respiratory syncytial virus, adenoviruses, rhinoviruses, and enteroviruses. Standard sputum bacteriology was also performed. Outcome was recorded at a follow up visit. RESULTS: Potential pathogens were identified in 55 patients with LRTI (69%) and seven controls (14%; p<0.0001). The identification rate was 63% (viruses) and 26% (bacteria) for patients and 12% (p<0.0001) and 6% (p = 0.013), respectively, for controls. The most common organisms identified in the patients were rhinoviruses (33%), influenza viruses (24%), and Streptococcus pneumoniae (19%) compared with 2% (p<0.001), 6% (p = 0.013), and 4% (p = 0.034), respectively, in controls. Multiple pathogens were identified in 18 of the 80 LRTI patients (22.5%) and in two of the 49 controls (4%; p = 0.011). Atypical organisms were rarely identified. Cases with bacterial aetiology were clinically indistinguishable from those with viral aetiology. CONCLUSION: Patients presenting to GPs with acute adult LRTI predominantly have a viral illness which is most commonly caused by rhinoviruses and influenza viruses

Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

‘It’s not about disability, I want to win as many medals as possible’: The social construction of disability in high-performance coaching.

This article draws on the theoretical concepts of Pierre Bourdieu to provide a critical analysis of the social construction of disability in high-performance sport coaching. Data were generated using a qualitative cross-case comparative methodology, comprising 18 months of ethnographic fieldwork in high-performance disability sport, and interviews with coaches and athletes from a cross-section of Paralympic sports. We discuss how in both cases ‘disability’ was assimilated into the ‘performance logic’ of the sporting field as a means of maximising symbolic capital. Furthermore, coaches were socialised into a prevailing legitimate culture in elite disability sport that was reflective of ableist, performance-focused and normative ideologies about disability. In this article we unpack the assumptions that underpin coaching in disability sport, and by extension use sport as a lens to problematise the construction of disability in specific social formations across coaching cultures. In so doing, we raise critical questions about the interrelation of disability and sport

Single-step fabrication of thin-film linear variable bandpass filters based on metal-insulator-metal geometry

A single-step fabrication method is presented for ultra-thin, linearly variable optical bandpass filters (LVBFs) based on a metal–insulator–metal arrangement using modified evaporation deposition techniques. This alternate process methodology offers reduced complexity and cost in comparison to conventional techniques for fabricating LVBFs. We are able to achieve linear variation of insulator thickness across a sample, by adjusting the geometrical parameters of a typical physical vapor deposition process. We demonstrate LVBFs with spectral selectivity from 400 to 850 nm based on Ag (25 nm) and MgF$_{2}$ (75–250 nm). Maximum spectral transmittance is measured at ∼70% with a $\textit{Q}$-factor of ∼20.Engineering and Physical Sciences Research Council (EPSRC) (EP/L015455/1); Cambridge Commonwealth, European and International Trust