543 research outputs found
The Student-Athlete Life/Career Portfolio: A Multifaceted Approach to Life and Career Development
The student-athlete life/career portfolio is a process that developed reflective practice and allowed for an in-depth portrayal of the experiences of each person as an individual and an athlete. The contents of the life/career portfolio provided a unique document that is far more illustrative of an individual's abilities and achievement sthan the traditional resume
How U.S. Ocean Policy and Market Power Can Reform the Coral Reef Wildlife Trade
As the world’s largest importer of marine ornamental species for the aquaria, curio, home décor, and jewelry industries, the United States has an opportunity to leverage its considerable market power to promote more sustainable trade and reduce the effects of ornamental trade stress on coral reefs worldwide. Evidence indicates that collection of some coral reef animals for these trades has caused virtual elimination of local populations, major changes in age structure, and promotion of collection practices that destroy reef habitats. Management and enforcement of collection activities in major source countries such as Indonesia and the Philippines remain weak. Strengthening US trade laws and enforcement capabilities combined with increasing consumer and industry demand for responsible conservation can create strong incentives for improving management in source countries. This is particularly important in light of the March 2010 failure of the parties to the Convention on International Trade in Endangered Species (CITES) to take action on key groups of corals
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Using a Robust and Sensitive GFP-Based cGMP Sensor for Real-Time Imaging in Intact Caenorhabditis elegans.
cGMP plays a role in sensory signaling and plasticity by regulating ion channels, phosphodiesterases, and kinases. Studies that primarily used genetic and biochemical tools suggest that cGMP is spatiotemporally regulated in multiple sensory modalities. FRET- and GFP-based cGMP sensors were developed to visualize cGMP in primary cell culture and Caenorhabditis elegans to corroborate these findings. While a FRET-based sensor has been used in an intact animal to visualize cGMP, the requirement of a multiple emission system limits its ability to be used on its own as well as with other fluorophores. Here, we demonstrate that a C. elegans codon-optimized version of the cpEGFP-based cGMP sensor FlincG3 can be used to visualize rapidly changing cGMP levels in living, behaving C. elegans We coexpressed FlincG3 with the blue-light-activated guanylyl cyclases BeCyclOp and bPGC in body wall muscles, and found that the rate of change in FlincG3 fluorescence correlated with the rate of cGMP production by each cyclase. Furthermore, we show that FlincG3 responds to cultivation temperature, NaCl concentration changes, and sodium dodecyl sulfate in the sensory neurons AFD, ASEL/R, and PHB, respectively. Intriguingly, FlincG3 fluorescence in ASEL and ASER decreased in response to a NaCl concentration upstep and downstep, respectively, which is opposite in sign to the coexpressed calcium sensor jRGECO1a and previously published calcium recordings. These results illustrate that FlincG3 can be used to report rapidly changing cGMP levels in an intact animal, and that the reporter can potentially reveal unexpected spatiotemporal landscapes of cGMP in response to stimuli
The design-by-adaptation approach to universal access: learning from videogame technology
This paper proposes an alternative approach to the design of universally accessible interfaces to that provided by formal design frameworks applied ab initio to the development of new software. This approach, design-byadaptation, involves the transfer of interface technology and/or design principles from one application domain to another, in situations where the recipient domain is similar to the host domain in terms of modelled systems, tasks and users. Using the example of interaction in 3D virtual environments, the paper explores how principles underlying the design of videogame interfaces may be applied to a broad family of visualization and analysis software which handles geographical data (virtual geographic environments, or VGEs). One of the motivations behind the current study is that VGE technology lags some way behind videogame technology in the modelling of 3D environments, and has a less-developed track record in providing the variety of interaction methods needed to undertake varied tasks in 3D virtual worlds by users with varied levels of experience. The current analysis extracted a set of interaction principles from videogames which were used to devise a set of 3D task interfaces that have been implemented in a prototype VGE for formal evaluation
Theory of interlayer exchange interactions in magnetic multilayers
This paper presents a review of the phenomenon of interlayer exchange
coupling in magnetic multilayers. The emphasis is put on a pedagogical
presentation of the mechanism of the phenomenon, which has been successfully
explained in terms of a spin-dependent quantum confinement effect. The
theoretical predictions are discussed in connection with corresponding
experimental investigations.Comment: 18 pages, 4 PS figures, LaTeX with IOP package; v2: ref. added.
Further (p)reprints available from http://www.mpi-halle.de/~theory
Observation of two time scales in the ferromagnetic manganite La(1-x)Ca(x)MnO(3), x = 0.3
We report new zero-field muon spin relaxation and neutron spin echo
measurements in ferromagnetic (FM) (La,Ca)MnO3 which taken together suggest two
spatially separated regions in close proximity possessing very different Mn-ion
spin dynamics. One region corresponds to an extended cluster which displays
'critical slowing down' near Tc and an increasing volume fraction below Tc. The
second region possesses more slowly fluctuating spins and a decreasing volume
fraction below Tc. These data are discussed in terms of the growth of small
polarons into overlapping regions of correlated spins below Tc, resulting in a
microscopically inhomogeneous FM transition.Comment: 10 pages, 3 figure
Annealing-Dependent Magnetic Depth Profile in Ga[1-x]Mn[x]As
We have studied the depth-dependent magnetic and structural properties of
as-grown and optimally annealed Ga[1-x]Mn[x]As films using polarized neutron
reflectometry. In addition to increasing total magnetization, the annealing
process was observed to produce a significantly more homogeneous distribution
of the magnetization. This difference in the films is attributed to the
redistribution of Mn at interstitial sites during the annealing process. Also,
we have seen evidence of significant magnetization depletion at the surface of
both as-grown and annealed films.Comment: 5 pages, 3 figure
Regulatory Improvement Legislation: Risk Assessment, Cost-Benefit Analysis, and Judicial Review
As the number, cost, and complexity of federal regulations have grown over the past twenty years, there has been growing interest in the use of analytic tools such as risk assessment and cost-benefit analysis to improve the regulatory process. The application of these tools to public health, safety, and environmental problems has become commonplace in the peer-reviewed scientific and medical literatures. Recent studies prepared by Resources for the Future, the American Enterprise Institute, the Brookings Institution, and the Harvard Center for Risk Analysis have demonstrated how formal analyses can and often do help government agencies achieve more protection against hazards at less cost than would otherwise occur. Although analytic tools hold great promise, their use by federal agencies is neither consistent nor rigorous.
The 103rd, 104th, 105th and 106th Congresses demonstrated sustained interest in the passage of comprehensive legislation governing the employment of these tools in the federal regulatory process. While legislative proposals on this issue have attracted significant bipartisan interest, and recent amendments to particular enabling statutes have incorporated some of these analytical requirements, no comprehensive legislation has been enacted into law since passage of the Administrative Procedure Act in 1946.
The inability to pass such legislation has been attributed to a variety of factors, but a common substantive concern has been uncertainty and controversy about how such legislation should address judicial review issues. For example, the judicial review portion of The Regulatory Improvement Act (S. 981), the 105th Congress\u27s major legislative initiative, was criticized simultaneously as meaningless (for allegedly offering too few opportunities for petitioners to challenge poorly reasoned agency rules) and dangerous (as supposedly enabling petitioners to paralyze even well-reasoned agency rules). Thus, a significant obstacle to regulatory improvement legislation appears to be the conflicting opinions among legal scholars and practitioners about how judicial review issues should be addressed in such legislation. The Clinton Administration and the authors of S. 981 believe they have crafted a workable compromise, one that accommodates the need to bring more rigor and transparency to an agency\u27s decisional processes without imposing excessive judicial review. Nevertheless, it is clear that their agreement on this subject, if included in future legislative deliberations, will be scrutinized and contested.
Recognizing the importance of the judicial review issue to this and, indeed, any effort to improve the regulatory process, the Center for Risk Analysis at the Harvard School of Public Health convened an invitational Workshop of accomplished legal practitioners and scholars to discuss how judicial review should be handled in legislation of this kind. The full-day Workshop was conducted in Washington, D.C. on December 17, 1998. Its purpose was to discuss principles, experiences, and insights that might inform future public debate about how judicial review should be addressed in legislative proposals that entail use of risk assessment and/or cost-benefit analysis in agency decision-making (whether the proposals are comprehensive or agency-specific).
In order to provide the Workshop a practical focus, participants analyzed the provisions of S. 981 (as modified at the request of the Clinton Administration). An exchange of letters between S. 981\u27s chief sponsors and the Clinton Administration defining the terms of the agreement was examined as well. This Report highlights the themes of the Workshop discussion and offers some specific commentary on how proposed legislation (including but not limited to S. 981) could be improved in future legislative deliberations
Magnetic fluctuations in frustrated Laves hydrides R(Mn_{1-x}Al_{x})_{2}H_{y}
By neutron scattering, we have studied the spin correlations and spin
fluctuations in frustrated Laves hydrides, where magnetic disorder sets in the
topologically frustrated Mn lattice. Below the transition towards short range
magnetic order, static spin clusters coexist with fluctuating and alsmost
uncorrelated spins. The magnetic response shows a complexe lineshape, connected
with the presence of the magnetic inhomogeneities. Its analysis shows the
existence of two different processes, relaxation and local excitations, for the
spin fluctuations below the transition. The paramagnetic fluctuations are
discussed in comparison with classical spin glasses, cluster glasses, and non
Fermi liquid itinerant magnets
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