On the dust and gas content of high-redshift galaxies hosting obscured AGN in the CDF–S

Submillimeter Galaxies (SMGs) at high redshift are among the best targets to investigate the early evolutionary phases in the lifetime of massive systems, during which large gas reservoirs sustain vigorous star formation and efficiently feed the central, buried Super Massive Black Hole (SMBH), until it enters into luminous Quasar (QSO) phase, quenching the star formation. I present the analysis of new ALMA band 4 (1.8-2.4 mm) data of six obscured QSOs (log NH > 23) hosted by SMGs at redshift > 2.5 in the 7 Ms Chandra Deep Field South (CDF-S), showing their properties in terms of continuum dust emission and high-J CO transitions. Sizes and masses of the galaxies are measured to estimate whether and to which extent the host ISM may contribute to the nuclear absorption, assuming different geometries. The derived column densities suggest that the galaxy ISM can substantially contribute to the AGN obscuration. I also discuss the kinematics and morphology in some of these object, finding that two of the sources present unambiguous features of a rotating system, while a third source is possibly undergoing a merger

On the dust and gas content of high-redshift galaxies hosting obscured AGN in the CDF–S

Submillimeter Galaxies (SMGs) at high redshift are among the best targets to investigate the early evolutionary phases in the lifetime of massive systems, during which large gas reservoirs sustain vigorous star formation and efficiently feed the central, buried Super Massive Black Hole (SMBH), until it enters into luminous Quasar (QSO) phase, quenching the star formation. I present the analysis of new ALMA band 4 (1.8-2.4 mm) data of six obscured QSOs (log NH > 23) hosted by SMGs at redshift > 2.5 in the 7 Ms Chandra Deep Field South (CDF-S), showing their properties in terms of continuum dust emission and high-J CO transitions. Sizes and masses of the galaxies are measured to estimate whether and to which extent the host ISM may contribute to the nuclear absorption, assuming different geometries. The derived column densities suggest that the galaxy ISM can substantially contribute to the AGN obscuration. I also discuss the kinematics and morphology in some of these object, finding that two of the sources present unambiguous features of a rotating system, while a third source is possibly undergoing a merger

Serum IgG2 levels are specifically associated with whole-body insulin-mediated glucose disposal in non-diabetic offspring of type 2 diabetic individuals. a cross-sectional study

.Preclinical studies suggested that IgG2c isotype may specifically impair skeletal muscle insulin sensitivity in mice. In this study we investigated the association between serum levels of the four IgG subclasses and insulin sensitivity in non-diabetic individuals. Total IgG, IgG1, IgG2, IgG3 and IgG4 levels were measured in 262 subjects. Whole-body insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. IgG2 levels were positively correlated with BMI, waist circumference, 2-h postload glucose levels and complement C3. Serum IgG2, but not IgG1, IgG3 and IgG4 levels were negatively correlated with whole-body insulin sensitivity (r = −0.17; P = 0.003) and muscle insulin sensitivity index (r = −0.16; P = 0.03) after adjustment for age and gender. No significant correlation was found between IgG2 levels and hepatic insulin resistance assessed by HOMA-IR and liver IR index. In a multivariable regression analysis including variables known to affect insulin sensitivity such as age, gender, BMI, smoking, lipids, inflammatory markers, fasting and 2-h post-load glucose levels, IgG2 levels were independently associated with insulin-stimulated glucose disposal (β = −0.115, 95% CI: −0.541 to −0.024; P = 0.03). These data demonstrate the independent association between higher levels of IgG2 and decreased whole-body insulin sensitivity, thus confirming in humans the animal-based evidence indicating the pathogenic role of IgG2 in insulin resistance

Modelagem bioeconômica da transferência de embriões em bovinos.

O objetivo deste trabalho foi desenvolver um modelo matemático orientado a eventos de simulação, para auxiliar tomadas de decisão relativas à transferência de embriões em bovinos, considerando-se as dinâmicas de dois componentes da transferência de embriões: receptoras e embriões. Na simulação, não se avaliaram respostas individuais de doadoras a coletas consecutivas e eventos correspondentes na transferência de embriões. Simulou-se o mesmo protocolo para superovulação a todas as doadoras. Receptoras foram sincronizadas simulando-se o uso de prostaglandina. O número de embriões viáveis produzido por doadora e sua variabilidade tiveram como base um processo aleatório de simulação de Monte Carlo, que pressupôs uma distribuição exponencial negativa de densidade de probabilidade. Custos e receitas foram inseridos no modelo por meio de um cenário-base para calcular indicadores econômicos de rentabilidade. A análise sugeriu a impraticabilidade da atividade, se realizada diante do cenário proposto (VPL ? R$: 57.596,69). A partir do cenário proposto, o custo médio estimado foi de R$ 1.178,19, e de R$ 980,03, para se obter uma prenhez a partir de uma situação otimizada, sugerida pelo modelo (5/100; 5/190)

Yield and incidence of hollow stem disorder of cauliflower 'Sharon' influenced by the application of nitrogen and boron

A podridão parda é um problema comum em couve-flor que ocasiona sintoma semelhante ao da deficiência de B. Sua ocorrência está associada, especialmente, às adubações com nitrogênio e boro, mas há escassez de informações sobre o problema no Brasil. Neste trabalho avaliou-se o efeito de doses de nitrogênio e épocas de aplicação de boro na produção e na incidência de podridão parda da couve-flor 'Sharon'. O experimento foi realizado em Argissolo Vermelho Amarelo de novembro/2005 a fevereiro/2006, com quatro doses de N (100; 150; 200 e 250 kg ha-1) e duas épocas de aplicação de 3 kg ha-1 B (1 e 2 aplicações), além do controle (sem aplicação). O diâmetro das cabeças e a produtividade comercial variaram de 16,45 a 22,03 cm e 15,71 a 29 t ha-1, respectivamente, e não foram influenciados pelos tratamentos. As doses de N proporcionaram aumento linear no teor nas folhas e nas cabeças. O caule oco e bronzeamento das cabeças foram reduzidos, enquanto a produtividade comercial aumentou com aplicação de B. Houve correlação negativa entre o teor de B nas folhas (r=0,66; p<0,05) e nas cabeças (r=0,76; p<0,05) e a incidência de caule oco. A adubação com B para a couve-flor cultivada em solo com teor médio (0,54 mg de B dm-3) é necessária para reduzir os sintomas da podridão parda. Contudo, mais estudos são necessários em outros solos e cultivares para redução desse distúrbio fisiológico em condições tropicais e melhoria da eficiência da adubação com boro.The hollow stem disorder is a common problem in cauliflower, resulting in similar symptoms as those caused by B deficiency. Its occurrence in cauliflower is related to nitrogen and boron levels. There exist little information about this subject in Brazil. The effect of nitrogen rates and boron application periods were evaluated on the cauliflower production and incidence of hollow stem. The experiment was carried out from November 2005 through February 2006 in a Kandiustalf soil (0.54 mg B kg-1, BaCl2 1.25 mg L-1) at Tietê region, São Paulo State, Brazil, in a randomized complete block design with four replicates, four N levels (100; 150; 200 and 250 kg ha-1) and two periods of B application (one and two applications) and a control (without application). Cauliflower curd diameter ranged from 16.45 to 22.03 cm and the commercial yield from 15.71 to 29 t ha-1; these two traits were not influenced by treatments. Nitrogen rates increased linearly in leaves and curds. The hollow stem and curd browning were reduced and commercial yield was increased with B fertilization. The correlation between B concentration on leaves (r= 0.66; p<0.05) and curds (r= 0.76; p<0.05) with hollow stem disorder was negative. Boron fertilization is necessary to reduce the symptoms of hollow stem when cauliflower is grow in soil with medium B level (0.54 mg B dm-3). More studies are needed using other types of soil and other cauliflower cultivars in order to reduce this physiological disorder in tropical conditions and increase the efficiency of boron fertilization

Impacto de uma experiência de quase-morte e conversão religiosa sobre a saúde mental de um criminoso: relato de caso e revisão da literatura

OBJECTIVE: Near-death experiences have been defined as profound psychological events that may occur to a person while close to death or in a situation of extreme physical or emotional distress. These experiences seem to have an important effect on the patients’ mental health and may occur in several situations despite their cultural and religious beliefs. CASE DESCRIPTION: The present case report describes the positive impact of a near-death experience (Greyson scale > 7) followed by religious conversion on the mental health of a former prisoner. COMMENTS: Investigation of the role of near-death experiences by the scientific community could shed light on the coping mechanisms and moral/ethical transformations that take place in these individuals.OBJETIVO: As experiências de quase-morte são definidas como eventos psicológicos profundos, que podem ocorrer quando uma pessoa está em morte iminente ou em situação de intensa crise física ou emocional. Essas experiências parecem ter efeito importante sobre a saúde mental desses pacientes e ocorrem em diversas situações, a despeito de culturas e crenças religiosas. RELATO DE CASO: O presente relato de caso descreve a influência positiva de uma experiência de quase-morte (escala de Greyson > 7) seguida de conversão religiosa sobre a saúde mental de um ex-detento. COMENTÁRIO: A investigação do papel de experiências de quase-morte em âmbito científico poderia ajudar a elucidar os mecanismos de coping e transformações éticas e morais que ocorrem nesses indivíduos.Universidade Federal de São Paulo (UNIFESP) Hospital São PauloAssociação Médico-Espírita de São PauloClínica OtossonoFaculdade de Ciências Médicas Santa Casa de São PauloInstituto de Psiquiatria Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloInstituto de Psiquiatria HCFMUSP Conselho Penitenciário do Estado de São PauloUniversidade Federal de Juiz de ForaHospital João EvangelistaUNIFESP, Hospital São PauloSciEL