Congruent and Incongruent Corticospinal Activations at the Level of Multiple Effectors

Motor resonance is defined as the subliminal activation of the motor system while observing actions performed by others. However, resonating with another person's actions is not always an appropriate response: In real life, people do not just imitate but rather respond in a suitable fashion. A growing body of neurophysiologic studies has demonstrated that motor resonance can be overridden by complementary motor responses (such as preparing a precision grip on a small object when seeing an open hand in sign of request). In this study, we investigated the relationship between congruent and incongruent corticospinal activations at the level of multiple effectors. The modulation of MEPs evoked by single-pulse TMS over the motor cortex was assessed in upper and lower limb muscles of participants observing a soccer player performing a penalty kick straight in their direction. Study results revealed a double dissociation: Seeing the soccer player kicking the ball triggered a motor resonance in the observer's lower limb, whereas the upper limb response afforded by the object was overridden. On the other hand, seeing the ball approaching the observers elicited a complementary motor activation in upper limbs while motor resonance in lower limbs disappeared. Control conditions showing lateral kicks, mimicked kicks, and a ball in penalty area were also included to test the motor coding of object affordances. Results point to a modulation of motor responses in different limbs over the course of action and in function of their relevance in different contexts. We contend that ecologically valid paradigms are nowadays needed to shed light on the motor system functioning in complex forms of interaction

Applied research by design: an experimental collaborative and interdisciplinary design charrette

This article reports on one experimental case of interdisciplinary collaboration on a design and planning exercise across several scales – local through urban to regional – and sectors – private, public, scholarly, and interest groups. The case is a collaborative and interdisciplinary design charrette on sustainable urbanism for envisioning the future of the Greater Metropolitan Area of Florence in Italy. The experiment entailed the attempt to integrate complex urban conditions via the design charrette in order to create more healthy and sustainable cities. This collaborative work shows how conditions that are at times not addressed comprehensively nor holistically can be combined through doing applied research by design; where design is understood as a process of discovery and creation that results in synthesis. The article details the methodology applied, and provides an initial assessment on the process that the charrette employed. Moreover, it highlights some professional and policy implications of the effort. Finally, it provides a provisional assessment on learning outcomes and addresses opportunities to improve future exercises of this nature

Factors influencing the pricing of applications in the Apple App Store: A developers\u2019 perspective

Many know how Apple Inc. owes its success in Mobile Commerce to the introduction of the new \u201cApp Store\u201d business model. This new market is characterized by the opening to third party mobile apps, which are distributed to consumers through the App Store. This paper investigates factors that might influence the pricing of applications in the Apple Mobile Application Store. By reviewing the existing literature on the issue and analyzing the strategic features characterizing the App Store, we detect three main factors that could influence prices for apps, that is the number of developed apps, the presence of two-sided network externalities and developer\u2019s specialization. An empirical analysis on data from 68,220 apps downloaded from the Italian App Store is used to test the hypotheses. Regression results support our hypotheses. We argue, that even if the research here presented can be considered as a started analysis to the pricing problem in such markets, this work may have important managerial implication for the thousands of developers that are competing in this emerging market

Instantaneous cell migration velocity may be ill-defined

Cell crawling is critical to biological development, homeostasis and disease. In many cases, cell trajectories are quasi-random-walk. In vitro assays on flat surfaces often described such quasi-random-walk cell trajectories as approximations to a solution of a Langevin process. However, experiments show quasi-diffusive behavior at small timescales, indicating that instantaneous velocity and velocity autocorrelations are not well-defined. We propose to characterize mean-squared cell displacement using a modified F\"urth equation with three temporal and spatial regimes: short- and long-time/range diffusion and intermediate time/range ballistic motion. This analysis collapses mean-squared displacements of previously published experimental data onto a single-parameter family of curves, allowing direct comparison between movement in different cell types, and between experiments and numerical simulations. Our method also show that robust cell-motility quantification requires an experiment with a maximum interval between images of a few percent of the cell-motion persistence time or less, and a duration of a few orders-of-magnitude longer than the cell-motion persistence time or more.Comment: 5 pages, plus Supplemental materia

Synthetic perspective optical flow: Influence on pilot control tasks

One approach used to better understand the impact of visual flow on control tasks has been to use synthetic perspective flow patterns. Such patterns are the result of apparent motion across a grid or random dot display. Unfortunately, the optical flow so generated is based on a subset of the flow information that exists in the real world. The danger is that the resulting optical motions may not generate the visual flow patterns useful for actual flight control. Researchers conducted a series of studies directed at understanding the characteristics of synthetic perspective flow that support various pilot tasks. In the first of these, they examined the control of altitude over various perspective grid textures (Johnson et al., 1987). Another set of studies was directed at studying the head tracking of targets moving in a 3-D coordinate system. These studies, parametric in nature, utilized both impoverished and complex virtual worlds represented by simple perspective grids at one extreme, and computer-generated terrain at the other. These studies are part of an applied visual research program directed at understanding the design principles required for the development of instruments displaying spatial orientation information. The experiments also highlight the need for modeling the impact of spatial displays on pilot control tasks

The effects of reduced physical activity on the lipid profile in patients with high cardiovascular risk during covid-19 lockdown

Background: The COVID-19 pandemic is a serious global health problem. In Italy, to limit the infections, the government ordered lockdown from March 2020. This measure, designed to contain the virus, led to serious limitations on the daily life of the individuals it affected, and in particular in the limitation of physical exercise. The aim of this study was to evaluate the effects of reduced physical activity on the lipid profile in patients with high cardiovascular risk. Methods: We enrolled 38 dyslipidemic patients, 56% male, with an age range of 44–62 years, considered to be at high cardiovascular risk. All patients were prescribed statin drug therapy (atorvastatin 40 mg) and a vigorous physical activity program four times a week, 1 h per session. In addition, a personalized Mediterranean diet was prescribed to all the patients. Total cholesterol, LDL, HDL and triglycerides were measured in patients at T0 before lockdown and at T1 during lockdown. Results: Data showed a significant increase (p < 0.01) in total cholesterol (+6,8%) and LDL (+15,8%). Furthermore, the analysis of the data revealed a reduction in HDL (−3%) and an increase in triglycerides (+3,2%), although both were not significant (p > 0.05). Conclusions: Our study showed that the reduction in physical activity during lockdown led to an increase in LDL levels, and therefore, in the risk of ischemic heart disease in dyslipidemic patients with high cardiovascular risk

SAFE: Simulation Automation Framework for Experiments

The workflow of a network simulation study requires adherence to best practices in methodology so that results are credible and reproducible by third parties. The opportunities for one to introduce errors start at model description and permeate the process through to the reporting of results. The literature indicates that even publications in respected venues include inadvertent mistakes and poor application of methodology. When experts are liable to fail, it is unreasonable to expect that students would fare any better. This paper presents a system designed to provide guidance for inexperienced users of the popular ns-3 network simulator. SAFE automates the workflow from the initialization of model parameters, to the parallelized execution of experiments, to the processing and persistent storage of output data, and to graphical visualization of results. We discuss the architecture and the implementation of the system in the context of similar contributions in the literature

Alpha particle thermodynamics in the inner heliosphere fast solar wind

Context. Plasma processes occurring in the corona and solar wind can be probed by studying the thermodynamic properties of different ion species. However, most in-situ observations of positive ions in the solar wind are taken at 1 AU, where information on their solar source properties may have been irreversibly erased. Aims. In this study we aimed to use the properties of alpha particles at heliocentric distances between 0.3 and 1 AU to study plasma processes occurring at the points of observation, and to infer processes occurring inside 0.3 AU by comparing our results to previous remote sensing observations of the plasma closer to the Sun. Methods. We reprocessed the original Helios positive ion distribution functions, isolated the alpha particle population, and computed the alpha particle number density, velocity, and magnetic field perpendicular and parallel temperatures. We then investigated the radial variation of alpha particle temperatures in fast solar wind observed between 0.3 and 1 AU. Results. Between 0.3 and 1 AU alpha particles are heated in the magnetic field perpendicular direction, and cooled in the magnetic field parallel direction. Alpha particle evolution is bounded by the alpha firehose instability threshold, which provides one possible mechanism to explain the observed parallel cooling and perpendicular heating. Closer to the Sun our observations suggest that the alpha particles undergo heating in the perpendicular direction, whilst the large magnetic field parallel temperatures observed at 0.3 AU may be due to the combined effect of double adiabatic expansion and alpha particle deceleration inside 0.3 AU