1,499 research outputs found
Can colour vision re-evolve? Variation in the X-linked opsin locus of cathemeral Azara’s owl monkeys (Aotus azarae azarae)
Background: Do evolutionary specializations lead to evolutionary constraint? This appears plausible, particularly when specialization leads to loss of complex adaptations. In the owl monkey lineage, nocturnality clearly arose from a diurnal ancestor. This behavioural shift was accompanied by morphological changes in the eye and orbit and complete loss of colour vision via missense mutations in the gene encoding the short-wave sensitive visual pigment (SWS opsin). Interestingly, at least one subspecies of owl monkey, Azara’s owl monkey (Aotus azarae azarae), has regained activity in daylight. Given that all primate species that are active in daylight, including primarily diurnal species and species that are active during both day and night, have at least dichromatic colour vision, it seems reasonable to propose that dichromacy would be adaptive in A. a. azarae. With a disabled SWS opsin, the main avenue available for Azara’s owl monkeys to re-evolve colour vision is via a polymorphism in the intact X-linked opsin locus, which commonly occurs in other New World monkeys. To examine this possibility we assayed variation in the X-linked opsin of A. a. azarae, focusing on the three exons (3, 4 and 5) that control spectral sensitivity.
Results: We found low opsin genetic variation on a population level, and no differences at the three main sites that lead to variation in spectral sensitivity in the opsins of other New World monkeys. Two rare alleles with single amino acid variants are segregating in the population, but previous functional studies indicate that these are unlikely to affect spectral sensitivity.
Conclusions: Genetic constraint on the re-evolution of colour vision is likely operating in Azara’s owl monkey, which may affect the niche that this subspecies is able to occupy
Girls’ and women’s education within Unesco and the World Bank, 1945–2000
By 2000, girls’ and women’s education was a priority for international development organisations. While studies have examined the impact of recent campaigns and programmes, there has been less exploration of ideas about girls’ and women’s education within development thought in the immediate post?colonial period, and the political mechanisms through which this came to be a global concern. Through a study of policy documents, this paper investigates how the education of girls and women came to be prioritised within the two principle UN agencies involved with education since 1945, the World Bank and Unesco. A shift in priorities is evident, from ensuring formal rights and improving the status of women, to expanding the productive capacities of women, fertility control and poverty reduction. While the ascendance of human capital theory provided a space for a new perception of the role of women’s education in development, in other policy arenas women’s education was central to exploring more substantive, rights?based notions of gender equality. Ultimately, the goal of improving girls’ and women’s education fitted into diverse development agendas, paving the way for it to become a global development priority
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Chemistry of H2O and HF Under Extreme Conditions
The predicted high pressure superionic phases of water and HF are investigated via ab initio molecular dynamics. These phases could potentially be achieved through either static compression with heating or through shock compression. We study water at densities of 2.0-3.0 g/cc (34-115 GPa) along the 2000K isotherm.We find that extremely rapid (superionic) diffusion of protons occurs in a fluid phase at pressures between 34 and 58 GPa. A transition to a stable body-centered cubic (bcc) O lattice with superionic proton conductivity is observed between 70 and 75 GPa, a much higher pressure than suggested in prior work. We find that all molecular species at pressures greater than 75 GPa are too short lived to be classified as bound states. Up to 95 GPa, we find a solid superionic phase characterized by covalent O-H bonding. Above 95 GPa, a transient network phase is found characterized by symmetric O-H hydrogen bonding with nearly 50% covalent character. Ab initio molecular dynamics simulations of HF were conducted at densities of 1.8-4.0 g/cc along the 900 K isotherm. According to our simulations, a unique form of (symmetric) hydrogen bonding could play a significant role in superionic conduction. Our work shows that superionic phases could be more prevalent in hydrogen bonded systems than previously thought, such as HCl and HBr
Simian immunodeficiency virus infection in wild-caught chimpanzees from Cameroon
Simian immunodeficiency viruses (SIVcpz) infecting chimpanzees (Pan troglodytes) in west central Africa are the closest relatives to all major variants of human immunodeficiency virus type 1 ([HIV-1]; groups M, N and O), and have thus been implicated as the source of the human infections; however, information concerning the prevalence, geographic distribution, and subspecies association of SIVcpz still remains limited. In this study, we tested 71 wild-caught chimpanzees from Cameroon for evidence of SIVcpz infection. Thirty-nine of these were of the central subspecies (Pan troglodytes troglodytes), and 32 were of the Nigerian subspecies (Pan troglodytes vellerosus), as determined by mitochondrial DNA analysis. Serological analysis determined that one P. t. troglodytes ape (CAM13) harbored serum antibodies that cross-reacted strongly with HIV-1 antigens; all other apes were seronegative. To characterize the newly identified virus, 14 partially overlapping viral fragments were amplified from fecal virion RNA and concatenated to yield a complete SIVcpz genome (9,284 bp). Phylogenetic analyses revealed that SIVcpzCAM13 fell well within the radiation of the SIVcpzPtt group of viruses, as part of a clade including all other SIVcpzPtt strains as well as HIV-1 groups M and N. However, SIVcpzCAM13 clustered most closely with SIVcpzGAB1 from Gabon rather than with SIVcpzCAM3 and SIVcpzCAM5 from Cameroon, indicating the existence of divergent SIVcpzPtt lineages within the same geographic region. These data, together with evidence of recombination among ancestral SIVcpzPtt lineages, indicate long-standing endemic infection of central chimpanzees and reaffirm a west central African origin of HIV-1. Whether P. t. vellerosus apes are naturally infected with SIVcpz requires further study
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Non-molecular Phases of H2O and HF Under Detonation-like Conditions
Energetic materials are known to produce simple molecular species, such as HF and H{sub 2}O, during detonation. The behavior of such species under conditions of simultaneous high pressure and temperature are unknown. The predicted high pressure superionic phases of water and HF are investigated via ab initio molecular dynamics. We study water at densities of 2.0-3.0 g/cc (34 -115 GPa) along the 2000 K isotherm. We find that extremely rapid (superionic) diffusion of protons occurs in a fluid phase at pressures between 34 and 58 GPa. A transition to a stable body-centered cubic (bcc) O lattice with superionic proton conductivity is observed between 70 and 75 GPa. We find that all molecular species at pressures greater than 75 GPa are too short lived to be classified as bound states. Up to 95 GPa, we find a solid superionic phase characterized by covalent O-H bonding. Above 95 GPa, a transient network phase is found characterized by symmetric O-OH hydrogen bonding with nearly 50% covalent character. Ab initio molecular dynamics H simulations of HF were conducted at densities of 1.8-4.0 g/cc along the 900 K isotherm. According to our simulations, a unique form of (symmetric) hydrogen bonding could play a significant role in superionic conduction. Our work shows that the Chapman-Jouget and Zeldovich-von Neumann Doring (ZND) states of some energetic materials are close to the molecular to non-molecular transition
A multi-wavelength analysis for interferometric (sub-)mm observations of protoplanetary disks: radial constraints on the dust properties and the disk structure
Theoretical models of grain growth predict dust properties to change as a
function of protoplanetary disk radius, mass, age and other physical
conditions. We lay down the methodology for a multi-wavelength analysis of
(sub-)mm and cm continuum interferometric observations to constrain
self-consistently the disk structure and the radial variation of the dust
properties. The computational architecture is massively parallel and highly
modular. The analysis is based on the simultaneous fit in the uv-plane of
observations at several wavelengths with a model for the disk thermal emission
and for the dust opacity. The observed flux density at the different
wavelengths is fitted by posing constraints on the disk structure and on the
radial variation of the grain size distribution. We apply the analysis to
observations of three protoplanetary disks (AS 209, FT Tau, DR Tau) for which a
combination of spatially resolved observations in the range ~0.88mm to ~10mm is
available (from SMA, CARMA, and VLA), finding evidence of a decreasing maximum
dust grain size (a_max) with radius. We derive large a_max values up to 1 cm in
the inner disk between 15 and 30 AU and smaller grains with a_max~1 mm in the
outer disk (R > 80AU). In this paper we develop a multi-wavelength analysis
that will allow this missing quantity to be constrained for statistically
relevant samples of disks and to investigate possible correlations with disk or
stellar parameters.Comment: 19 pages, 15 figures, accepted for publication in A&
The solar type protostar IRAS16293-2422: new constraints on the physical structure
Context: The low mass protostar IRAS16293-2422 is a prototype Class 0 source
with respect to the studies of the chemical structure during the initial phases
of life of Solar type stars. Aims: In order to derive an accurate chemical
structure, a precise determination of the source physical structure is
required. The scope of the present work is the derivation of the structure of
IRAS16293-2422. Methods: We have re-analyzed all available continuum data
(single dish and interferometric, from millimeter to MIR) to derive accurate
density and dust temperature profiles. Using ISO observations of water, we have
also reconstructed the gas temperature profile. Results: Our analysis shows
that the envelope surrounding IRAS16293-2422 is well described by the Shu
"inside-out" collapsing envelope model or a single power-law density profile
with index equal to 1.8. In contrast to some previous studies, our analysis
does not show evidence of a large (>/- 800 AU in diameter) cavity. Conclusions:
Although IRAS16293-2422 is a multiple system composed by two or three objects,
our reconstruction will be useful to derive the chemical structure of the large
cold envelope surrounding these objects and the warm component, treated here as
a single source, from single-dish observations of molecular emission
Precursors to social and communication difficulties in infants at-risk for autism: gaze following and attentional engagement
Whilst joint attention (JA) impairments in autism have been widely studied, little is known about the early development of gaze following, a precursor to establishing JA. We employed eye-tracking to record gaze following longitudinally in infants with and without a family history of autism spectrum disorder (ASD) at 7 and 13 months. No group difference was found between at-risk and low-risk infants in gaze following behaviour at either age. However, despite following gaze successfully at 13 months, at-risk infants with later emerging socio-communication difficulties (both those with ASD and atypical development at 36 months of age) allocated less attention to the congruent object compared to typically developing at-risk siblings and low-risk controls. The findings suggest that the subtle emergence of difficulties in JA in infancy may be related to ASD and other atypical outcomes
The Spitzer c2d Survey of Large, Nearby, Interstellar Clouds. I. Chamaeleon II Observed with MIPS
We present maps of over 1.5 square degrees in Chamaeleon (Cha) II at 24, 70,
and 160 micron observed with the Spitzer Space Telescope Multiband Imaging
Photometer for Spitzer (MIPS) and a 1.2 square degree millimeter map from SIMBA
on the Swedish-ESO Submillimetre Telescope (SEST). The c2d Spitzer Legacy
Team's data reduction pipeline is described in detail. Over 1500 24 micron
sources and 41 70 micron sources were detected by MIPS with fluxes greater than
10-sigma. More than 40 potential YSOs are identified with a MIPS and 2MASS
color-color diagram and by their spectral indices, including two previously
unknown sources with 24 micron excesses. Our new SIMBA millimeter map of Cha II
shows that only a small fraction of the gas is in compact structures with high
column densities. The extended emission seen by MIPS is compared with previous
CO observations. Some selected interesting sources, including two detected at 1
mm, associated with Cha II are discussed in detail and their SEDs presented.
The classification of these sources using MIPS data is found to be consistent
with previous studies.Comment: 44 pages, 12 figures (1 color), to be published in Ap
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