BotSwindler: Tamper Resistant Injection of Believable Decoys in VM-Based Hosts for Crimeware Detection

We introduce BotSwindler, a bait injection system designed to delude and detect crimeware by forcing it to reveal during the exploitation of monitored information. The implementation of BotSwindler relies upon an out-of-host software agent that drives user-like interactions in a virtual machine, seeking to convince malware residing within the guest OS that it has captured legitimate credentials. To aid in the accuracy and realism of the simulations, we propose a low overhead approach, called virtual machine verification, for verifying whether the guest OS is in one of a predefined set of states. We present results from experiments with real credential-collecting malware that demonstrate the injection of monitored financial bait for detecting compromises. Additionally, using a computational analysis and a user study, we illustrate the believability of the simulations and we demonstrate that they are sufficiently human-like. Finally, we provide results from performance measurements to show our approach does not impose a performance burden

Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.

OBJECTIVE: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. RESULTS: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age

Continuous and transparent multimodal authentication: reviewing the state of the art

Individuals, businesses and governments undertake an ever-growing range of activities online and via various Internet-enabled digital devices. Unfortunately, these activities, services, information and devices are the targets of cybercrimes. Verifying the user legitimacy to use/access a digital device or service has become of the utmost importance. Authentication is the frontline countermeasure of ensuring only the authorized user is granted access; however, it has historically suffered from a range of issues related to the security and usability of the approaches. They are also still mostly functioning at the point of entry and those performing sort of re-authentication executing it in an intrusive manner. Thus, it is apparent that a more innovative, convenient and secure user authentication solution is vital. This paper reviews the authentication methods along with the current use of authentication technologies, aiming at developing a current state-of-the-art and identifying the open problems to be tackled and available solutions to be adopted. It also investigates whether these authentication technologies have the capability to fill the gap between high security and user satisfaction. This is followed by a literature review of the existing research on continuous and transparent multimodal authentication. It concludes that providing users with adequate protection and convenience requires innovative robust authentication mechanisms to be utilized in a universal level. Ultimately, a potential federated biometric authentication solution is presented; however it needs to be developed and extensively evaluated, thus operating in a transparent, continuous and user-friendly manner

Neurocognition and quality of life after reinitiating antiretroviral therapy in children randomized to planned treatment interruption

Objective: Understanding the effects of antiretroviral treatment (ART) interruption on neurocognition and quality of life (QoL) are important for managing unplanned interruptions and planned interruptions in HIV cure research. Design: Children previously randomized to continuous (continuous ART, n=41) vs. planned treatment interruption (PTI, n=47) in the Pediatric European Network for Treatment of AIDS (PENTA) 11 study were enrolled. At study end, PTI children resumed ART. At 1 and 2 years following study end, children were assessed by the coding, symbol search and digit span subtests of Wechsler Intelligence Scale for Children (6-16 years old) or Wechsler Adult Intelligence Scale ( 6517 years old) and by Pediatrics QoL questionnaires for physical and psychological QoL. Transformed scaled scores for neurocognition and mean standardized scores for QoL were compared between arms by t-test and Mann-Whitney U test, respectively. Scores indicating clinical concern were compared (<7 for neurocognition and <70 for QoL tests). Results: Characteristics were similar between arms with a median age of 12.6 years, CD4 + of 830 cells/\u3bcl and HIV RNA of 1.7 log 10 copies/ml. The median cumulative ART exposure was 9.6 in continuous ART vs. 7.7 years in PTI (P=0.02). PTI children had a median of 12 months off ART and had resumed ART for 25.2 months at time of first assessment. Neurocognitive scores were similar between arms for all tests. Physical and psychological QoL scores were no different. About 40% had low neurocognitive and QoL scores indicating clinical concern. Conclusion: No differences in information processing speed, sustained attention, short-term memory and QoL functioning were observed between children previously randomized to continuous ART vs. PTI in the PENTA 11 trial

Assessment of the physical characteristics and stormwater effluent quality of permeable pavement systems containing recycled materials

This paper evaluates the physical characteristics of two recycled materials and the pollutant removal efficiencies of four 0.2 m2 tanked permeable pavement rigs in the laboratory, that contained either natural aggregates or these recycled materials in the sub-base. The selected recycled materials were Crushed Concrete Aggregates (CCA) and Cement-bounded Expanded Polystyrene beads (C-EPS) whilst the natural aggregates were basalt and quartzite. Natural stormwater runoff was used as influent. Effluent was collected for analysis after 7–10 mins of discharge. Influent and effluent were analysed for pH, Chemical Oxygen Demand (COD), Dissolved Oxygen (DO), Electroconductivity (EC), turbidity, Total Suspended Solids (TSS), Total Dissolved Solids (TDS), Nitrate-Nitrogen (NO3-N), reactive phosphorous (PO43-) and sulphates (SO42-). Both CCA and C-EPS had suitable physical properties for use as sub-base materials in PPS. However, C-EPS is recommended for use in pavements with light to no traffic because of its relatively low compressive strength. In terms of pollutant removal efficiencies, significant differences (p 0.05) were found with respect to TSS, turbidity, COD and NO3-N. Effluent from rigs containing CCA and C-EPS saw significant increases in pH, EC and TDS measurements whilst improvements in DO, TSS, turbidity, COD, PO43- and SO42- were observed. All mean values except pH were, however, within the Maximum Permissible Levels (MPLs) of water pollutants discharged into the environment according to the Trinidad and Tobago Environmental Management Authority (EMA) or the United States Environmental Protection Agency (US EPA). In this regard, the CCA and C-EPS performed satisfactorily as sub-base materials in the permeable pavement rigs. It is noted, however, that further analysis is recommended through leaching tests on the recycled materials

Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Background: Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand. Methods: Children aged <18 years initiating combination ART (≥2 nucleoside reverse transcriptase inhibitors [NRTIs] plus nonnucleoside reverse transcriptase inhibitor [NNRTI] or boosted protease inhibitor [PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of ≥1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks. Results: Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch. Conclusions: One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch

Effect of carbon-negative aggregates on the strength properties of concrete for permeable pavements

Permeable pavements are engineered to temporarily store water to reduce flooding during rainfall events. Permeable pavements are distinguished primarily based on their surface materials which can vary from concrete, asphalt, clay brick, concrete pavers or plastic grids. This paper examined the effect of lightweight carbon-negative aggregates (CNA) on the behaviour of concrete intended for use as solid concrete block pavers in permeable pavements. Performance indicators targeted compressive strength, splitting tensile strength, density and water absorption. CNA were produced and sourced from manufacturing firm Carbon8 Systems in Kent U.K which applies patented accelerated carbonation technology to solidify incinerated ash into useful eco-friendly aggregates. The methodology involved substituting natural aggregates (NA) by mass, with CNA at percentages varying from 0 to 100. A scanning electron microscope was used to examine the aggregate–mortar interface. Both the compressive and tensile strengths decreased exponentially with the addition of CNA. Average 28-day compressive and splitting tensile strengths ranged from 69 MPa (10,000 PSI) to 18 MPa (2600 PSI) and 3.84 MPa (560 PSI) to 1.23 MPa (178 PSI) respectively. Density values decreased linearly with the addtion of CNA with average values ranging from 2200–2600 kg/m3. ⁠Conversely, water absorption increased with increases in CNA with average values ranging from 1.66% to 9.17%. Depending on the loading requirements, CNA can replace NA in solid permeable pavement blocks by up to 100%