100 research outputs found
Validation of Continuous Glucose Monitoring in Children and Adolescents With Cystic Fibrosis: A prospective cohort study
OBJECTIVE: To validate continuous glucose monitoring (CGM) in children and adolescents with cystic fibrosis. RESEARCH DESIGN AND METHODS: Paired oral glucose tolerance tests (OGTTs) and CGM monitoring was undertaken in 102 children and adolescents with cystic fibrosis (age 9.5-19.0 years) at baseline (CGM1) and after 12 months (CGM2). CGM validity was assessed by reliability, reproducibility, and repeatability. RESULTS: CGM was reliable with a Bland-Altman agreement between CGM and OGTT of 0.81 mmol/l (95% CI for bias +/- 2.90 mmol/l) and good correlation between the two (r = 0.74-0.9; P < 0.01). CGM was reproducible with no significant differences in the coefficient of variation of the CGM assessment between visits and repeatable with a mean difference between CGM1 and CGM2 of 0.09 mmol/l (95% CI for difference +/- 0.46 mmol/l) and a discriminant ratio of 13.0 and 15.1, respectively. CONCLUSIONS: In this cohort of children and adolescents with cystic fibrosis, CGM performed on two occasions over a 12-month period was reliable, reproducible, and repeatable
Comparing Total Neoplasms, Breast & Prostate Cancer Mortality Rates of the UK and 20 Major Developed Countries 1989-91 v 2013- 15 - Identifying Progress
Introduction: Britain’s cancer survival results have
been criticised as being significantly higher than twenty
Major Developed Countries (MDC). Hence this
comparison of current UK Total Age-StandardisedDeath-Rates (ASDR), female Breast and Prostate cancer
mortality rates with twenty (MDC) between1989 to
2015 to determine any significant change.
Method: WHO data ASDR per million (pm) for Total,
Breast and Prostate cancer mortality rates examined for
the years 1989-91 to 2013-15. Confidence Intervals (+/-
95%) are used to determine any significant differences
between the UK and other country’s outcomes over the
period. Chi square tests for each nation’s Breast and
Prostate mortality.
Results: Every country’s Total ASDR, Breast and
Prostate cancer mortality fell except Greece and Japan.
Total ASDR Male cancer mortality rates ranged from
Portugal 1653pm to Sweden 1232pm. UK at 1475pm
were 10th but had been 6th highest. Total ASDR Female
rates went from Denmark’s 1176pm to Japan’s 740pm,
the UK 1092pm now 5th but previously had been second
highest. No country’s Total rates fell significantly more
than Britain’s who had significantly bigger reductions
than four other countries for both sexes. Breast
mortality ranged from Ireland’s 206pm to Japan’s
99pm, UK rates fell significantly more than five
countries. Whilst Breast mortality fell in every country
Norway and UK had significantly bigger reductions in
Breast than Prostate deaths, conversely France’s
Prostate rates fell more than Breast mortality. Prostate
mortality went from Norway 213pm Japan’s 60pm, the
UK 167pm and five countries had greater reductions
than Britain.
Conclusions: Results reflect well on UK services for
Total and Breast cancers, showing the NHS achieving
more with proportionately less as Britain spends less on
health than most MDC. The need how to improve UK
prostate results are briefly discussed, such as a public
information campaign to match the successful Breast
cancer aware programme of the 1990’s
Epidemiology, Pathophysiology, and Prognostic Implications of Cystic Fibrosis–Related Diabetes: A technical review
Clinical Care Guidelines for Cystic Fibrosis–Related Diabetes: A position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society
Elevation of 1-Hour Plasma Glucose During Oral Glucose Tolerance Testing Is Associated With Worse Pulmonary Function in Cystic Fibrosis
Genetic Determinants and Epidemiology of Cystic Fibrosis–Related Diabetes: Results from a British cohort of children and adults
OBJECTIVE—Longer survival of patients with cystic fibrosis has increased the occurrence of cystic fibrosis–related diabetes (CFRD). In this study we documented the incidence of CFRD and evaluated the association between mutations responsible for cystic fibrosis and incident CFRD, while identifying potential risk factors
Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study
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