Turbulent Flows and Pollution Dispersion around Tall Buildings Using Adaptive Large Eddy Simulation (LES)

The motivation for this work stems from the increased number of high-rise buildings/skyscrapers all over the world, and in London, UK, and hence the necessity to see their effect on the local environment. We concentrate on the mean velocities, Reynolds stresses, turbulent kinetic energies (TKEs) and tracer concentrations. We look at their variations with height at two main locations within the building area, and downstream the buildings. The pollution source is placed at the top of the central building, representing an emission from a Combined Heat and Power (CHP) plant. We see how a tall building may have a positive effect at the lower levels, but a negative one at the higher levels in terms of pollution levels. Mean velocities at the higher levels (over 60 m in real life) are reduced at both locations (within the building area and downstream it), whilst Reynolds stresses and TKEs increase. However, despite the observed enhanced turbulence at the higher levels, mean concentrations increase, indicating that the mean flow has a greater influence on the dispersion. At the lower levels (Z < 60 m), the presence of a tall building enhanced dispersion (hence lower concentrations) for many of the configurations

Elbow angle modulates corticospinal excitability to the resting biceps brachii at both spinal and supraspinal levels

NEW FINDINGS: What is the central question of this study? Corticospinal excitability to biceps brachii is known to modulate according to upper-limb posture. Here, cervicomedullary stimulation was used to investigate potential spinal contributions to elbow angle-dependent changes in corticospinal excitability at rest. What is the main finding and its importance? At more extended elbow angles, biceps responses to cervicomedullary stimulation were decreased, whereas cortically evoked responses (normalized to cervicomedullary-evoked responses) were increased. Results suggest decreased spinal excitability but increased cortical excitability as the elbow is placed in a more extended position, an effect that is unlikely to be attributable to cutaneous stretch receptor activation. ABSTRACT: Corticospinal excitability to biceps brachii is known to modulate according to upper-limb posture. In study 1, our aim was to investigate potential spinal contributions to this modulation and the independent effect of elbow angle. Biceps responses to transcranial magnetic stimulation (motor evoked potentials; MEPs) and electrical cervicomedullary stimulation (cervicomedullary motor evoked potentials; CMEPs) were measured at five elbow angles ranging from full extension to 130 deg of flexion. In study 2, possible contributions of cutaneous stretch receptors to elbow angle-dependent excitability changes were investigated by eliciting MEPs and CMEPs in three conditions of skin stretch about the elbow (stretch to mimic full extension, no stretch or stretch to mimic flexion). Each study had 12 participants. Evoked potentials were acquired at rest, with participants seated, the shoulder flexed 90 deg and forearm supinated. The MEPs and CMEPs were normalized to maximal compound muscle action potentials. In study 1, as the elbow was moved to more extended positions, there were no changes in MEPs (P = 0.963), progressive decreases in CMEPs (P \u3c 0.0001; CMEPs at 130 deg flexion ∼220% of full extension) and increases in the MEP/CMEP ratio (P = 0.019; MEP/CMEP at 130 deg flexion ∼20% of full extension). In study 2, there were no changes in MEPs (P = 0.830) or CMEPs (P = 0.209) between skin stretch conditions. Therefore, although results suggest a decrease in spinal and an increase in supraspinal excitability at more extended angles, the mechanism for these changes in corticospinal excitability to biceps is not cutaneous stretch receptor feedback

Suppression of electron relaxation and dephasing rates in quantum dots caused by external magnetic fields

An external magnetic field has been applied in laterally coupled dots (QDs) and we have studied the QD properties related to charge decoherence. The significance of the applied magnetic field to the suppression of electron-phonon relaxation and dephasing rates has been explored. The coupled QDs have been studied by varing the magnetic field and the interdot distance as other system parameters. Our numerical results show that the electron scattering rates are strongly dependent on the applied external magnetic field and the details of the double QD configuration.Comment: 13 pages, 6 figure

Random Walks in Local Dynamics of Network Losses

We suggest a model for data losses in a single node of a packet-switched network (like the Internet) which reduces to one-dimensional discrete random walks with unusual boundary conditions. The model shows critical behavior with an abrupt transition from exponentially small to finite losses as the data arrival rate increases. The critical point is characterized by strong fluctuations of the loss rate. Although we consider the packet arrival being a Markovian process, the loss rate exhibits non-Markovian power-law correlations in time at the critical point.Comment: 4 pages, 2 figure

Temporal Correlations of Local Network Losses

We introduce a continuum model describing data losses in a single node of a packet-switched network (like the Internet) which preserves the discrete nature of the data loss process. {\em By construction}, the model has critical behavior with a sharp transition from exponentially small to finite losses with increasing data arrival rate. We show that such a model exhibits strong fluctuations in the loss rate at the critical point and non-Markovian power-law correlations in time, in spite of the Markovian character of the data arrival process. The continuum model allows for rather general incoming data packet distributions and can be naturally generalized to consider the buffer server idleness statistics

Variants in the 3'UTR of the ovine Acetyl-Coenzyme A Acyltransferase 2 gene are associated with dairy traits and exhibit differential allelic expression

The acetyl-CoA acyltransferase 2 (ACAA2) gene encodes an enzyme of the thiolase family that is involved in mitochondrial fatty acid elongation and degradation by catalyzing the last step of the respective β-oxidation pathway. The increased energy needs for gluconeogenesis and triglyceride synthesis during lactation are met primarily by increased fatty acid oxidation. Therefore, the ACAA2 enzyme plays an important role in the supply of energy and carbon substrates for lactation and may thus affect milk production traits. This study investigated the association of the ACAA2 gene with important sheep traits and the putative functional involvement of this gene in dairy traits. A single nucleotide substitution, a T to C transition located in the 3′ untranslated region of the ACAA2 gene, was used in mixed model association analysis with milk yield, milk protein yield and percentage, milk fat yield and percentage, and litter size at birth. The single nucleotide polymorphism was significantly associated with total lactation production and milk protein percentage, with respective additive effects of 6.81 ± 2.95 kg and −0.05 ± 0.02%. Additionally, a significant dominance effect of 0.46 ± 0.21 kg was detected for milk fat yield. Homozygous TT and heterozygous CT animals exhibited higher milk yield compared with homozygous CC animals, whereas the latter exhibited increased milk protein percentage. Expression analysis from age-, lactation-, and parity-matched female sheep showed that mRNA expression of the ACAA2 gene from TT animals was 2.8- and 11.8-fold higher in liver and mammary gland, respectively. In addition, by developing an allelic expression imbalance assay, it was estimated that the T allele was expressed at an average of 18% more compared with the C allele in the udder of randomly selected ewes. We demonstrated for the first time that the variants in the 3′ untranslated region of the ovine ACAA2 gene are differentially expressed in homozygous ewes of each allele and exhibit allelic expression imbalance within heterozygotes in a tissue-specific manner, supporting the existence of cis-regulatory DNA variation in the ovine ACAA2 gene. This is the first study reporting differential allelic imbalance expression of a candidate gene associated with milk production traits in dairy sheep

On the use of polymer gels for assessing the total geometrical accuracy in clinical Gamma Knife radiosurgery applications

The nearly tissue equivalent MRI properties and the unique ability of registering 3D dose distributions of polymer gels were exploited to assess the total geometrical accuracy in clinical Gamma Knife applications, taking into account the combined effect of the unit’s mechanical accuracy, dose delivery precision and the geometrical distortions inherent in MR images used for irradiation planning. Comparison between planned and experimental data suggests that the MR-related distortions due to susceptibility effects dominate the total clinical geometrical accuracy which was found within 1 mm. The dosimetric effect of the observed sub-millimetre uncertainties on single shot GK irradiation plans was assessed using the target percentage coverage criterion, and a considerable target dose underestimation was found

Broadband characterisation of interior materials and surface scattering using terahertz time-domain spectroscopy

Indoor wireless communications need to move towards Terahertz (THz) frequencies in order to keep up with society's demand for data transmission, but this change is currently hindered by limited knowledge of material properties and propagation and scattering models at these frequencies. The dielectric properties of common household materials are investigated here with a twofold objective: (1) to extend the library of material properties at THz, and (2) to estimate and disentangle losses in scattering measurements in order to facilitate propagation, scattering and, ultimately, channel models