Prediction of explosive yield and other characteristics of liquid propellant rocket explosions Final report

Explosive hazards and yield predictions for liquid rocket propellant

Future large hydropower dams impact global freshwater megafauna

Dam construction comes with severe social, economic and ecological impacts. From an ecological point of view, habitat types are altered and biodiversity is lost. Thus, to identify areas that deserve major attention for conservation, existing and planned locations for (hydropower) dams were overlapped, at global extent, with the contemporary distribution of freshwater megafauna species with consideration of their respective threat status. Hydropower development will disproportionately impact areas of high freshwater megafauna richness in South America, South and East Asia, and the Balkan region. Sub-catchments with a high share of threatened species are considered to be most vulnerable; these are located in Central America, Southeast Asia and in the regions of the Black and Caspian Sea. Based on this approach, planned dam locations are classified according to their potential impact on freshwater megafauna species at different spatial scales, attention to potential conflicts between climate mitigation and biodiversity conservation are highlighted, and priorities for freshwater management are recommended

Channel Density Regulation of Firing Patterns in a Cortical Neuron Model

AbstractModifying the density and distribution of ion channels in a neuron (by natural up- and downregulation or by pharmacological intervention or by spontaneous mutations) changes its activity pattern. In this investigation we analyzed how the impulse patterns are regulated by the density of voltage-gated channels in a neuron model based on voltage-clamp measurements of hippocampal interneurons. At least three distinct oscillatory patterns, associated with three distinct regions in the Na-K channel density plane, were found. A stability analysis showed that the different regions are characterized by saddle-node, double-orbit, and Hopf-bifurcation threshold dynamics, respectively. Single, strongly graded action potentials occur in an area outside the oscillatory regions, but less graded action potentials occur together with repetitive firing over a considerable range of channel densities. The relationship found here between channel densities and oscillatory behavior may partly explain the difference between the principal spiking patterns previously described for crab axons (class 1 and 2) and cortical neurons (regular firing and fast spiking)

_Grundgesetze_ and the Sense/Reference Distinction

Frege developed the theory of sense and reference while composing his Grundgesetze and considering its philosophical implications. The Grundgesetze is thus the most important test case for the application of this theory of meaning. I argue that evidence internal and external to the Grundgesetze suggests that he thought of senses as having a structure isomorphic to the Grundgesetze expressions that would be used to express them, which entails a theory about the identity conditions of senses that is relatively fine-grained, though still coarser than some other commentators have suggested. While this interpretation does not make Frege’s ontological commitment to the denizens of a “third realm” as profligate as some have alleged, it is sufficiently bloated to lead to Cantorian paradoxes and diagonal contradictions independent of his Basic Law V

Logical Form and the Development of Russell’s Logicism

Logicism is the view that mathematical truths are logical truths. But a logical truth is commonly thought to be one with a universally valid form. The form of “7 \u3e 5” would appear to be the same as “4 \u3e 6”. Yet one is a mathematical truth, and the other not a truth at all. To preserve logicism, we must maintain that the two either are different subforms of the same generic form, or that their forms are not at all what they appear. The historical record shows that Russell pursued both these options, but that the struggle with the logical paradoxes pushed him away from the first kind of response and toward the second. An object cannot itself have a kind of inner logical complexity that makes a proposition have a different logical form merely in virtue of being about it, nor can their representatives in logical forms be single things different for different forms, at least not without postulating too many such objects and thereby creating Cantorian diagonal paradoxes. There are only apparent objects which are actually fragments of logical forms, different in different cases