Few cycle pulse propagation

We present a comprehensive framework for treating the nonlinear interaction of few-cycle pulses using an envelope description that goes beyond the traditional SVEA method. This is applied to a range of simulations that demonstrate how the effect of a $\chi^{(2)}$ nonlinearity differs between the many-cycle and few-cycle cases. Our approach, which includes diffraction, dispersion, multiple fields, and a wide range of nonlinearities, builds upon the work of Brabec and Krausz[1] and Porras[2]. No approximations are made until the final stage when a particular problem is considered. The original version (v1) of this arXiv paper is close to the published Phys.Rev.A. version, and much smaller in size.Comment: 9 pages, 14 figure

Long-term results of a multicenter SAKK trial on high-dose ifosfamide and doxorubicin in advanced or metastatic gynecologic sarcomas

Background: Dose intensive chemotherapy has not been tested prospectively for the treatment of gynecologic sarcomas. We investigated the antitumor activity and toxicity of high-dose ifosfamide and doxorubicin, in the context of a multidisciplinary strategy for the treatment of advanced and metastatic, not pretreated, gynecologic sarcomas. Patients and methods: Thirty-nine patients were enrolled onto a phase I-II multicenter trial of ifosfamide, 10 g/m2 as a continuous infusion over 5 days, plus doxorubicin intravenously, 25 mg/m2/day for 3 days with Mesna and granulocyte-colony-stimulating factor every 21 days. Salvage therapy was allowed after chemotherapy. Results: Among the 37 evaluable patients, the tumor was locally advanced (n = 11), with concomitant distant metastases (n = 5) or with distant metastases only (n = 21). After a median of three (range 1-7) chemotherapy cycles, six patients experienced a complete response and 12 a partial response for an overall response rate of 49% (95% CI 32% to 66%). The response rate was higher in poorly differentiated tumors (62%) compared with moderately well differentiated ones (18%), but was not different according to histology subtypes. Eleven patients had salvage therapy, either immediately following chemotherapy (n = 7) or at time of progression (n = 4). With a median follow-up time of 5 years, the median overall survival was 30.5 months. Hematological toxicity was as expected neutropenia, thrombopenia and anemia ≥grade 3 at 50%, 34% and 33% of cycles respectively. No toxic death occurred. Conclusions: High-dose ifosfamide plus doxorubicin is an active regimen for all subtypes of gynecological sarcomas. Its toxicity was manageable in a multicentric setting. The prolonged survival might be due to the multidisciplinary strategy that was possible in one-third of the patient

The North American Reporting Center for Amphibian Malformations

The North American Reporting Center for Amphibian Malformations was established to provide a conduit of information about, and a systematic data base on, malformed amphibians. This article describes the Reporting Center and the variety of features available at its Web site, presents an example of a summary analysis that can be conducted with its data, discusses caveats about the data, and makes recommendations about systematic surveys to better understand patterns and trends in the incidence of malformed amphibians

Variation in survival after diagnosis of breast cancer in Switzerland

Background: Survival after diagnosis of cancer is a key criterion for cancer control. Major survival differences between time periods and countries have been reported by the EUROCARE studies. We investigated whether similar differences by period and region existed in Switzerland. Methods: Survival of 11 376 cases of primary invasive female breast cancer diagnosed between 1988 and 1997 and registered in seven Swiss cancer registries covering a population of 3.5 million was analysed. Results: Comparing the two periods 1988-1992 and 1993-1997, age-standardized 5 year relative survival improved globally from 77% to 81%. Furthermore, multivariate analysis adjusting for age, tumour size and nodal involvement identified regional survival differences. Survival was lowest in the rural parts of German-speaking eastern Switzerland and highest in urbanised regions of the Latin- and German-speaking northwestern parts of the country. Conclusions: This study confirms that survival differences are present even in a small and affluent, but culturally diverse, country like Switzerland, raising the issue of heterogeneity in access to care and quality of treatmen

Evolution of the nuclear modification factors with rapidity and centrality in d+Au collisions at $\sqrt{s_{NN}} = 200 GeV

We report on a study of the transverse momentum dependence of nuclear modification factors $R_{dAu}$ for charged hadrons produced in deuteron + gold collisions at $\sqrt{s_{NN}}= 200$GeV, as a function of collision centrality and of the pseudorapidity ($\eta = 0,1,2.2,3.2$) of the produced hadrons. We find significant and systematic decrease of $R_{dAu}$ with increasing rapidity. The midrapidity enhancement and the forward rapidity suppression are more pronounced in central collisions relative to peripheral collisions. These results are relevant to the study of the possible onset of gluon saturation at RHIC energies.Comment: Four pages, four figures. Published in PRL. Figures 1 and 2 have been updated, and several changes made to the tex

Mapping of periodically poled crystals via spontaneous parametric down-conversion

A new method for characterization of periodically poled crystals is developed based on spontaneous parametric down-conversion. The method is demonstrated on crystals of Y:LiNbO3, Mg:Y:LiNbO3 with non-uniform periodically poled structures, obtained directly under Czochralski growth procedure and designed for application of OPO in the mid infrared range. Infrared dispersion of refractive index, effective working periods and wavelengths of OPO were determined by special treatment of frequency-angular spectra of spontaneous parametric down-conversion in the visible range. Two-dimensional mapping via spontaneous parametric down-conversion is proposed for characterizing spatial distribution of bulk quasi-phase matching efficiency across the input window of a periodically poled sample.Comment: 19 pages, 6 figure

TAB Bonded SSD Module for the STAR and ALICE Trackers

Presentation made at LEB99, 20-24 September 1999A novel compact detector module has been produced by the "IReS"-"Subatech"-"Thomson-CSF-Detexis" collaboration. It includes a Double-Sided (DS) Silicon Strip Detector (SSD) and the related Front End Electronics (FEE) located on two hybrids, one for the N side and one for the P side. Bumpless Tape Automated Bonding (TAB) is used to connect the detector to the hybrids by means of microcables with neither wirebonding nor pitch adapter. Each of the six dedicated ALICE128C FE chip [1], located on the hybrid, is TABed on identical single layer microcables, which connect its inputs to the DS SSD and its outputs to the hybrid [2]. These microcables are bent in order to fold over the two hybrids on the DS SSD. This module meets the specifications of two experiments, ALICE (A Large Ion Collider Experiment) on the LHC accelerator at CERN [3] and STAR (Solenoid Tracker At Rhic) on the RHIC accelerator at BNL (Brookhaven National Laboratory)[4]. It can be used with air cooling (STAR) as well as with water cooling (ALICE)[5]. This mechanically self-consistent FE module has been tested on the SPS beam at CERN. Preliminary results are presented

Recent Results from the BRAHMS Experiment

We present recent results obtained by the BRAHMS experiment at the Relativistic Heavy Ion Collider (RHIC) for the systems of Au + Au and Cu + Cu at \rootsnn{200} and at 62.4 GeV, and p + p at \rootsnn{200}. Nuclear modification factors for Au + Au and Cu + Cu collisions are presented. Analysis of anti-particle to particle ratios as a function of rapidity and collision energy reveal that particle populations at the chemical freeze-out stage for heavy-ion reactions at and above SPS energies are controlled by the baryon chemical potential. From the particle spectra we deduce significant radial expansion ($\beta \approx$ 0.75), as expected for systems created with a large initial energy density. We also measure the elliptic flow parameter $v_2$ versus rapidity and \ptn. We present rapidity dependent $p/\pi$ ratios within $0 < y < 3$ for Au + Au and Cu + Cu at \rootsnn{200}. \Raa is found to increase with decreasing collision energy, decreasing system size, and when going towards more peripheral collisions. However, \Raa shows only a very weak dependence on rapidity (for $0 < y < 3.2$), both for pions and protons.Comment: 16 pages and 14 figures, proceedings for plenary talk at Quark Matter 2005, Budapest, Hungar

Electric-field-induced coherent coupling of the exciton states in a single quantum dot

The signature of coherent coupling between two quantum states is an anticrossing in their energies as one is swept through the other. In single semiconductor quantum dots containing an electron-hole pair the eigenstates form a two-level system that can be used to demonstrate quantum effects in the solid state, but in all previous work these states were independent. Here we describe a technique to control the energetic splitting of these states using a vertical electric field, facilitating the observation of coherent coupling between them. Near the minimum splitting the eigenstates rotate in the plane of the sample, being orientated at 45{\deg} when the splitting is smallest. Using this system we show direct control over the exciton states in one quantum dot, leading to the generation of entangled photon pairs

Nuclear Stopping in Au+Au Collisions at sqrt(sNN) = 200 GeV

Transverse momentum spectra and rapidity densities, dN/dy, of protons, anti-protons, and net--protons (p-pbar) from central (0-5%) Au+Au collisions at sqrt(sNN) = 200 GeV were measured with the BRAHMS experiment within the rapidity range 0 < y < 3. The proton and anti-proton dN/dy decrease from mid-rapidity to y=3. The net-proton yield is roughly constant for y<1 at dN/dy~7, and increases to dN/dy~12 at y~3. The data show that collisions at this energy exhibit a high degree of transparency and that the linear scaling of rapidity loss with rapidity observed at lower energies is broken. The energy loss per participant nucleon is estimated to be 73 +- 6 GeV.Comment: 5 pages, 4 figure