3,116 research outputs found

    Carbonic anhydrase iii s-glutathionylation is necessary for anti-oxidant activity

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    Cartographic research in EREP program for small scale mapping

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    The author has identified the following significant results. Skylab photography is suitable for producing planimetric maps with graphical representation of landform at scales up to 1:100,000. It cannot supply all the detail necessary for maps at this scale, but it may be used to produce a sound framework which can be completed by detail from other sources. Its principal cartographic use is for original mapping of undeveloped areas of the world, but it would also be useful for the revision of existing maps and for monitoring extensive urban changes

    Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head andeck, despite loss of heterozygosity at this locus

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    The human tumour suppressor gene PTEN located at 10q23 is mutated in a variety of tumour types particularly metastatic cases and in the germline of some individuals with Cowdens cancer predisposition syndrome. We have assessed the status of PTEN and associated pathways in cell lines derived from 19 squamous cell carcinomas of the head and neck. Loss of heterozygosity is evident at, or close to the PTEN gene in 5 cases, however there were no mutations in the remaining alleles. Furthermore by Western analysis PTEN protein levels are normal in all of these SCC-HN tumours and cell lines. To assess the possibility that PTEN may be inactivated by another mechanism, we characterized lipid phosphatase levels and from a specific PIP3 biochemical assay it is clear that PTEN is functionally active in all 19 human SCCs. Our data strongly suggest the possibility that a tumour suppressor gene associated with development of SCC-HN, other than PTEN, is located in this chromosomal region. This gene does not appear to be MXI-1, which has been implicated in some other human tumour types. PTEN is an important negative regulator of PI3Kinase, of which subunit alpha is frequently amplified in SCC-HN. To examine the possibility that PI3K is upregulated by amplification in this tumour set we assessed the phosphorylation status of Akt, a downstream target of PI3K. In all cases there is no detectable increase in Akt phosphorylation. Therefore there is no detectable defect in the PI3K pathway in SCC-HN suggesting that the reason for 3q26.3 over-representation may be due to genes other than PI3K110α. © 2001 Cancer Research Campaign http://www.bjcancer.co

    Benefits of undergraduate participation in faculty research in natural resources

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    Graduate student assistance with faculty research is common in university natural resource programs. Traditionally, undergraduate students are involved less with research programs of faculty. The Uintah Basin Branch Campus of Utah State University provides a unique setting for developing research projects in natural resources that involve undergraduates. We use a research project on the control of greasewood (Sarcobatus vermiculatus) iin the Book Cliffs, Utah to illustrate the benefits and challenges for undergraduate students and faculty of collaboration on research. Students benefit by interacting with faculty outside the classroom; by applying classroom learning to field problems; and by working with natural resource management personnel. Faculty benefit by observing the ability of students to apply classroom learning to field situations; by maintaining a scholarly research program; and by interacting with students outside the classroom

    Predatory journals recruit fake editor

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    An investigation finds that dozens of academic titles offered ‘Dr Fraud’ — a sham, unqualified scientist — a place on their editorial board. Katarzyna Pisanski and colleagues report

    Fragmentation and systematics of the Pygmy Dipole Resonance in the stable N=82 isotones

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    The low-lying electric dipole (E1) strength in the semi-magic nucleus 136Xe has been measured which finalizes the systematic survey to investigate the so-called pygmy dipole resonance (PDR) in all stable even N=82 isotones with the method of nuclear resonance fluorescence using real photons in the entrance channel. In all cases, a fragmented resonance-like structure of E1 strength is observed in the energy region 5 MeV to 8 MeV. An analysis of the fragmentation of the strength reveals that the degree of fragmentation decreases towards the proton-deficient isotones while the total integrated strength increases indicating a dependence of the total strength on the neutron-to-proton ratio. The experimental results are compared to microscopic calculations within the quasi-particle phonon model (QPM). The calculation includes complex configurations of up to three phonons and is able to reproduce also the fragmentation of the E1 strength which allows to draw conclusions on the damping of the PDR. Calculations and experimental data are in good agreement in the degree of fragmentation and also in the integrated strength if the sensitivity limit of the experiments is taken into account

    Photoactivation experiment on 197Au and its implications for the dipole strength in heavy nuclei

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    The 197Au(gamma,n) reaction is used as an activation standard for photodisintegration studies on astrophysically relevant nuclei. At the bremsstrahlung facility of the superconducting electron accelerator ELBE (Electron Linear accelerator of high Brilliance and low Emittance) of Forschungszentrum Dresden-Rossendorf, photoactivation measurements on 197Au have been performed with bremsstrahlung endpoint energies from 8.0 to 15.5 MeV. The measured activation yield is compared with previous experiments as well as with calculations using Hauser-Feshbach statistical models. It is shown that the experimental data are best described by a two-Lorentzian parametrization with taking the axial deformation of 197Au into account. The experimental 197Au(gamma,n) reaction yield measured at ELBE via the photoactivation method is found to be consistent with previous experimental data using photon scattering or neutron detection methods.Comment: 9 page
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