Tropospheric delay performance for GNSS integrated water vapor estimation by using GPT2w model, ECMWF's IFS operational model and in situ meteorological data

Tropospheric delay comprises one of the most important error sources in satellite navigation and is caused when radio signals broadcasted by GPS satellites propagate into the atmosphere. It is usually projected onto zenith direction by using mapping functions named as Zenith Tropospheric Delay (ZTD). ZTD is described as the sum of the Zenith Hydrostatic Delay (ZHD) and the Zenith Wet Delay (ZWD) and with the aid of surface pressure and temperature the integrated water vapor can be estimated. The main objective of this study is to evaluate the tropospheric delay performance for GNSS integrated water vapor estimation by using GPT2w model, ECMWF's IFS (ECMWF stands for the European Centre for Medium-Range Weather Forecasts) reanalysis model and ground meteorological data from two stations of the permanent network of Cyprus and Greece. The period from 27 May to 3 June 2018 is characterized by two different synoptic conditions: high pressure with fair weather in central Mediterranean (Greece), on the one hand, and high instability over the upper levels of the atmosphere that resulted in thunderstorms inland and mountainous areas during midday over the Eastern Mediterranean (Cyprus), on the other hand. In general, the results show that both the empirical blind model GPT2w and the ECMWF (IFS) operational model perform well in particular over Nicosia when used for the retrieval of Integrated Water Vapor (IWV) from GNSS measurements, although appreciable deviations were observed between ECMWF (IFS)-retrieved IWV and the one retrieved from GNSS observations by using meteorological measurements. A sharp increase of IWV prior to the abrupt rainfall events during noon on 30 and 31 May over Nicosia was also found.</p

Clusterin overexpression in mice exacerbates diabetic phenotypes but suppresses tumor progression in a mouse melanoma model

Clusterin (CLU) is an ATP-independent small heat shock protein-like chaperone, which functions both intra- and extra-cellularly. Consequently, it has been functionally involved in several physiological (including aging), as well as in pathological conditions and most age-related diseases, e.g., cancer, neurodegeneration, and metabolic syndrome. To address CLU function at an in vivo model we established CLU transgenic (Tg) mice bearing ubiquitous or pancreas-targeted CLU overexpression (OE). Our downstream analyses in established Tg lines showed that ubiquitous or pancreas-targeted CLU OE in mice affected antioxidant, proteostatic and metabolic pathways. Targeted OE of CLU in the pancreas, which also resulted in CLU upregulation in the liver likely via systemic effects, increased basal glucose levels in the circulation and exacerbated diabetic phenotypes. Furthermore, by establishing a syngeneic melanoma mouse tumor model we found that ubiquitous CLU OE suppressed melanoma cells growth, indicating a likely tumor suppressor function in early phases of tumorigenesis. Our observations provide in vivo evidence corroborating the notion that CLU is a potential modulator of metabolic and/or proteostatic pathways playing an important role in diabetes and tumorigenesis

Atmospheric Temperature anomalies as manifestation of the dark Universe

We are investigating the possible origin of small-scale anomalies, like the annual stratospheric temperature anomalies. Unexpectedly within known physics, their observed planetary "dependency", does not match concurrent solar activity, whose impact on the atmosphere is unequivocal; this points at an additional energy source of exo-solar origin. A viable concept behind such observations is based on possible gravitational focusing by the Sun and its planets towards the Earth of low-speed invisible streaming matter; its influx towards the Earth gets temporally enhanced. Only a somehow "strongly" interacting invisible streaming matter with the small upper atmospheric screening can be behind the observed temperature excursions. Ordinary dark matter (DM) candidates like axions or WIMPs, cannot have any noticeable impact. The associated energy deposition is $\mathcal{O}(\sim 1000\, \mathrm{GeV}/{{\mathrm{cm}}^2}/\mathrm{sec})$. The atmosphere has been uninterruptedly monitored for decades. Therefore, the upper atmosphere can serve as a novel (low-threshold) detector for the dark Universe, with built-in spatiotemporal resolution while the solar system gravity acts temporally as a signal amplifier. Interestingly, the anomalous ionosphere shows a relationship with the inner earth activity like earthquakes. Similarly investigating the transient sudden stratospheric warmings within the same reasoning, the nature of the assumed "invisible streams" could be deciphered.Comment: 8 pages, 7 figures, Published in the proceedings of the "15th International Conference on Meteorology, Climatology and Atmospheric Physics (COMECAP 2021)" see https://www.conferre.gr/allevents/comecap2020/Proceedings_Final.pd

Multilocus Microsatellite Typing (MLMT) of Strains from Turkey and Cyprus Reveals a Novel Monophyletic L. donovani Sensu Lato Group

In eastern Mediterranean, leishmaniasis represents a major public health problem with considerable impact on morbidity and potential to spread. Cutaneous leishmaniasis (CL) caused by L. major or L. tropica accounts for most cases in this region although visceral leishmaniasis (VL) caused by L. infantum is also common. New foci of human CL caused by L. donovani complex strains were recently described in Cyprus and Turkey. Herein we analyzed Turkish strains from human CL foci in Çukurova region (north of Cyprus) and a human VL case in Kuşadasi. These were compared to Cypriot strains that were previously typed by Multilocus Enzyme Electrophoresis (MLEE) as L. donovani MON-37. Nevertheless, they were found genetically distinct from MON-37 strains of other regions and therefore their origin remained enigmatic. A population study was performed by Multilocus Microsatellite Typing (MLMT) and the profile of the Turkish strains was compared to previously analyzed L. donovani complex strains. Our results revealed close genetic relationship between Turkish and Cypriot strains, which form a genetically distinct L. infantum monophyletic group, suggesting that Cypriot strains may originate from Turkey. Our analysis indicates that the epidemiology of leishmaniasis in this region is more complicated than originally thought

Observations of quiet-time moderate midlatitude L-band scintillation in association with plasma bubbles

Observations of moderate night time amplitude scintillation on the GPS L1C/A signal were recorded at the midlatitude station of Nicosia, corresponding geographic latitude and longitude of 35.18˚N and 33.38˚E respectively, on a geomagnetically quiet day. The variations of slant total electron content (STEC) and amplitude scintillation index (S4) on the night of June 12, 2014, indicate the presence of electron density depletions accompanying scintillation occurrence. The estimated apparent horizontal drift velocity and propagation direction of the plasma depletions are consistent with those observed for the equatorial plasma bubbles, thus suggesting that the moderate amplitude L-band scintillation observed over Nicosia may be associated with the extension of such plasma bubbles. The L-band scintillation occurrence was concurrent with the observations of range spread F on the ionograms recorded by the digisonde at Nicosia. The height–time–intensity plot generated using the ionogram data also showed features which can be attributed to off-angle reflections from electron density depletions, thus corroborating the STEC observations. This observation suggests that the midlatitude ionosphere is more active even during geomagnetically quiet days than previously thought and that further studies are necessary. This is particularly relevant for the GNSS user community and related applications

The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review

Background: The World Health Organization has identified studies of the role of host genetics on susceptibility to severe influenza as a priority. A systematic review was conducted to summarize the current state of evidence on the role of host genetics in susceptibility to influenza (PROSPERO registration number: CRD42011001380). Methods and Findings: PubMed, Web of Science, the Cochrane Library, and OpenSIGLE were searched using a pre-defined strategy for all entries up to the date of the search. Two reviewers independently screened the title and abstract of 1,371 unique articles, and 72 full text publications were selected for inclusion. Mouse models clearly demonstrate that host genetics plays a critical role in susceptibility to a range of human and avian influenza viruses. The Mx genes encoding interferon inducible proteins are the best studied but their relevance to susceptibility in humans is unknown. Although the MxA gene should be considered a candidate gene for further study in humans, over 100 other candidate genes have been proposed. There are however no data associating any of these candidate genes to susceptibility in humans, with the only published study in humans being under-powered. One genealogy study presents moderate evidence of a heritable component to the risk of influenza-associated death, and while the marked familial aggregation of H5N1 cases is suggestive of host genetic factors, this remains unproven. Conclusion: The fundamental question ‘‘Is susceptibility to severe influenza in humans heritable?’ ’ remains unanswered. No

Twelve empty seats : reflections on judge only trials after jury tampering

Original article can be found at : http://www.criminalbar.com/ Copyright Criminal Bar Association [Full text of this article is not available in the UHRA]For the first time in legal history the Central Criminal Court is sitting at the Royal Courts of Justice in a judge alone trial. R. v T; R. v B; R. v C; R. v H (“R. v T”)1 has proved to be highly controversial. The trial, taking place in Court 35, has attracted the attention of practitioners, academics, the media and subsequently, the general public. It is no exaggeration to say that this landmark decision will have a lasting impact on the nature of the adversarial criminal trial.Peer reviewe