Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy.

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation that mimics and occurs with other systemic diseases. A 35-year-old female presented with signs of viral illness at 13 weeks of pregnancy and progressed to acute liver failure (ALF). We discuss the diagnosis of HLH and Kikuchi-Fujimoto (KF) lymphadenitis in the context of pregnancy and ALF. HLH may respond to comorbid disease-specific therapy, and more toxic treatment can be avoided

The XMM-Newton Ω\Omega Project

The abundance of high-redshift galaxy clusters depends sensitively on the matter density \OmM and, to a lesser extent, on the cosmological constant $\Lambda$. Measurements of this abundance therefore constrain these fundamental cosmological parameters, and in a manner independent and complementary to other methods, such as observations of the cosmic microwave background and distance measurements. Cluster abundance is best measured by the X-ray temperature function, as opposed to luminosity, because temperature and mass are tightly correlated, as demonstrated by numerical simulations. Taking advantage of the sensitivity of XMM-Newton, our Guaranteed Time program aims at measuring the temperature of the highest redshift (z>0.4) SHARC clusters, with the ultimate goal of constraining both \OmM and $\Lambda$.Comment: To appear in the Proceedings of the XXI Moriond Conference: Galaxy Clusters and the High Redshift Universe Observed in X-rays, edited by D. Neumann, F. Durret, & J. Tran Thanh Va

Sequential and Spontaneous Star Formation Around the Mid-Infrared Halo HII Region KR 140

We use 2MASS and MSX infrared observations, along with new molecular line (CO) observations, to examine the distribution of young stellar objects (YSOs) in the molecular cloud surrounding the halo HII region KR 140 in order to determine if the ongoing star-formation activity in this region is dominated by sequential star formation within the photodissociation region (PDR) surrounding the HII region. We find that KR 140 has an extensive population of YSOs that have spontaneously formed due to processes not related to the expansion of the HII region. Much of the YSO population in the molecular cloud is concentrated along a dense filamentary molecular structure, traced by C18O, that has not been erased by the formation of the exciting O star. Some of the previously observed submillimetre clumps surrounding the HII region are shown to be sites of recent intermediate and low-mass star formation while other massive starless clumps clearly associated with the PDR may be the next sites of sequential star formation.Comment: Accepted for publication in MNRAS, 8 pages, 10 figure

A Sample of Intermediate-Mass Star-Forming Regions: Making Stars at Mass Column Densities <1 g/cm^2

In an effort to understand the factors that govern the transition from low- to high-mass star formation, we identify for the first time a sample of intermediate-mass star-forming regions (IM SFRs) where stars up to - but not exceeding - 8 solar masses are being produced. We use IRAS colors and Spitzer Space Telescope mid-IR images, in conjunction with millimeter continuum and CO maps, to compile a sample of 50 IM SFRs in the inner Galaxy. These are likely to be precursors to Herbig AeBe stars and their associated clusters of low-mass stars. IM SFRs constitute embedded clusters at an early evolutionary stage akin to compact HII regions, but they lack the massive ionizing central star(s). The photodissociation regions that demarcate IM SFRs have typical diameters of ~1 pc and luminosities of ~10^4 solar luminosities, making them an order of magnitude less luminous than (ultra)compact HII regions. IM SFRs coincide with molecular clumps of mass ~10^3 solar masses which, in turn, lie within larger molecular clouds spanning the lower end of the giant molecular cloud mass range, 10^4-10^5 solar masses. The IR luminosity and associated molecular mass of IM SFRs are correlated, consistent with the known luminosity-mass relationship of compact HII regions. Peak mass column densities within IM SFRs are ~0.1-0.5 g/cm^2, a factor of several lower than ultra-compact HII regions, supporting the proposition that there is a threshold for massive star formation at ~1 g/cm^2.Comment: 61 pages, 6 tables, 20 figures. Accepted for publication in the Astronomical Journa

Role of the (Mn)superoxide dismutase of Enterococcus faecalis in the in vitro interaction with microglia

Enterococcus faecalis is a significant human pathogen worldwide and is responsible for severenosocomial and community-acquired infections. Although enterococcal meningitis is rare,mortality is considerable, reaching 21 %. Nevertheless, the pathogenetic mechanisms of thisinfection remain poorly understood, even though the ability of E. faecalis to avoid or survivephagocytic attack in vivo may be very important during the infection process. We previouslyshowed that the manganese-cofactored superoxide dismutase (MnSOD) SodA of E. faecalis wasimplicated in oxidative stress responses and, interestingly, in the survival within mouse peritonealmacrophages using an in vivo\u2013in vitro infection model. In the present study, we investigated therole of MnSOD in the interaction of E. faecalis with microglia, the brain-resident macrophages. Byusing an in vitro infection model, murine microglial cells were challenged in parallel with the wildtypestrain JH2-2 and its isogenic sodA deletion mutant. While both strains were phagocytosedby microglia efficiently and to a similar extent, the DsodA mutant was found to be significantlymore susceptible to microglial killing than JH2-2, as assessed by the antimicrobial protectionassay. In addition, a significantly higher percentage of acidic DsodA-containing phagosomes wasfound and these also underwent enhanced maturation as determined by the expression ofendolysosomal markers. In conclusion, these results show that the MnSOD of E. faecaliscontributes to survival of the bacterium in microglial cells by influencing their antimicrobial activity,and this could even be important for intracellular killing in neutrophils and thus for E. faecalispathogenesis

Submillimeter mapping and analysis of cold dust condensations in the Orion M42 star forming complex

We present here the continuum submillimeter maps of the molecular cloud around the M42 Nebula in the Orion region. These have been obtained in four wavelength bands (200, 260, 360 and 580 microns) with the ProNaOS two meter balloon-borne telescope. The area covered is 7 parsecs wide (50 arcmin at a distance of 470 pc) with a spatial resolution of about 0.4 parsec. Thanks to the high sensitivity to faint surface brightness gradients, we have found several cold condensations with temperatures ranging from 12 to 17 K, within 3 parsecs of the dense ridge. The statistical analysis of the temperature and spectral index spatial distribution shows an evidence of an inverse correlation between these two parameters. Being invisible in the IRAS 100 micron survey, some cold clouds are likely to be the seeds for future star formation activity going on in the complex. We estimate their masses and we show that two of them have masses higher than their Jeans masses, and may be gravitationally unstable.Comment: 4 figures, The Astrophysical Journal, Main Journal, in pres