2,932 research outputs found
Flow Conductance of a Single Nanohole
The mass flow conductance of single nanoholes with diameter ranging from 75
to 100 nm was measured using mass spectrometry. For all nanoholes, a smooth
crossover is observed between single-particle statistical flow (effusion) and
the collective viscous flow emanating from the formation of a continuum. This
crossover is shown to occur when the gas mean free path matches the size of the
nanohole diameter. As a consequence of the pinhole geometry, the breakdown of
the Poiseuille approximation is observed in the power-law temperature exponent
of the measured conductance
Multiscale Modeling of Binary Polymer Mixtures: Scale Bridging in the Athermal and Thermal Regime
Obtaining a rigorous and reliable method for linking computer simulations of
polymer blends and composites at different length scales of interest is a
highly desirable goal in soft matter physics. In this paper a multiscale
modeling procedure is presented for the efficient calculation of the static
structural properties of binary homopolymer blends. The procedure combines
computer simulations of polymer chains on two different length scales, using a
united atom representation for the finer structure and a highly coarse-grained
approach on the meso-scale, where chains are represented as soft colloidal
particles interacting through an effective potential. A method for combining
the structural information by inverse mapping is discussed, allowing for the
efficient calculation of partial correlation functions, which are compared with
results from full united atom simulations. The structure of several polymer
mixtures is obtained in an efficient manner for several mixtures in the
homogeneous region of the phase diagram. The method is then extended to
incorporate thermal fluctuations through an effective chi parameter. Since the
approach is analytical, it is fully transferable to numerous systems.Comment: in press, 13 pages, 7 figures, 6 table
Viable thermionic emission from graphene-covered metals
Thermionic emission from monolayer graphene grown on representative
transition metals, Ir and Ru, is characterized by low-energy electron
microscopy (LEEM). Work functions were determined from the temperature
dependence of the emission current and from the electron energy spectrum of
emitted electrons. The high-temperature work function of the strongly
interacting system graphene/Ru(0001) is sufficiently low, 3.3 \pm 0.1 eV, to
have technological potential for large-area emitters that are spatially
uniform, efficient, and chemically inert. The thermionic work functions of the
less strongly interacting system graphene/Ir(111) are over 1 eV larger and vary
substantially (0.4 eV) between graphene orientations rotated by 30{\deg}.Comment: Published in Applied Physics Letter
Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer
Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered during cancer and has been associated with the invasion of cancer cells and metastasis. In this study, we report a previously unknown role for the cytoplasmic promyelocytic leukaemia (cPML) tumour suppressor in TGF-β signalling-induced regulation of prostate cancer-associated EMT and invasion. We demonstrate that cPML promotes a mesenchymal phenotype and increases the invasiveness of prostate cancer cells. This event is associated with activation of TGF-β canonical signalling pathway through the induction of Sma and Mad related family 2 and 3 (SMAD2 and SMAD3) phosphorylation. Furthermore, the cytoplasmic localization of promyelocytic leukaemia (PML) is mediated by its nuclear export in a chromosomal maintenance 1 (CRM1)-dependent manner. This was clinically tested in prostate cancer tissue and shown that cytoplasmic PML and CRM1 co-expression correlates with reduced disease-specific survival. In summary, we provide evidence of dysfunctional TGF-β signalling occurring at an early stage in prostate cancer. We show that this disease pathway is mediated by cPML and CRM1 and results in a more aggressive cancer cell phenotype. We propose that the targeting of this pathway could be therapeutically exploited for clinical benefit
How metal films de-wet substrates - identifying the kinetic pathways and energetic driving forces
We study how single-crystal chromium films of uniform thickness on W(110)
substrates are converted to arrays of three-dimensional (3D) Cr islands during
annealing. We use low-energy electron microscopy (LEEM) to directly observe a
kinetic pathway that produces trenches that expose the wetting layer. Adjacent
film steps move simultaneously uphill and downhill relative to the staircase of
atomic steps on the substrate. This step motion thickens the film regions where
steps advance. Where film steps retract, the film thins, eventually exposing
the stable wetting layer. Since our analysis shows that thick Cr films have a
lattice constant close to bulk Cr, we propose that surface and interface stress
provide a possible driving force for the observed morphological instability.
Atomistic simulations and analytic elastic models show that surface and
interface stress can cause a dependence of film energy on thickness that leads
to an instability to simultaneous thinning and thickening. We observe that
de-wetting is also initiated at bunches of substrate steps in two other
systems, Ag/W(110) and Ag/Ru(0001). We additionally describe how Cr films are
converted into patterns of unidirectional stripes as the trenches that expose
the wetting layer lengthen along the W[001] direction. Finally, we observe how
3D Cr islands form directly during film growth at elevated temperature. The Cr
mesas (wedges) form as Cr film steps advance down the staircase of substrate
steps, another example of the critical role that substrate steps play in 3D
island formation
Antecedents and outcomes of consumer environmentally friendly attitudes and behaviour
With the intensification of problems relating to the environment, a growing number of consumers are becoming more ecologically conscious in their preferences and purchases of goods. This paper presents the results of a study conducted among 500 Cypriot consumers, focusing on the factors that shape consumer environmental attitudes and behaviour, as well as on the resulting outcomes. The findings confirmed that both the inward and outward environmental attitudes of a consumer are positively influenced by his/her degree of collectivism, long-term orientation, political involvement, deontology, and law obedience, but have no connection with liberalism. The adoption of an inward environmental attitude was also found to be conducive to green purchasing behaviour that ultimately leads to high product satisfaction. On the other hand, an outward environmental attitude facilitates the adoption of a general environmental behaviour, which is responsible for greater satisfaction with life. The findings of the study have important implications for shaping effective company offerings to consumers in target markets, as well as formulating appropriate policies at the governmental level to enhance environmental sensitivity among citizens
Phosphorylation of the androgen receptor is associated with reduced survival in hormonerefractory prostate cancer patients
Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR). The current study therefore aims to establish if this has relevance to the development of clinical HRPC. Immunohistochemistry was employed to investigate the expression and phosphorylation status of Akt and AR in matched hormone-sensitive and -refractory prostate cancer tumours from 68 patients. In the hormone-refractory tissue, only phosphorylated AR (pAR) was associated with shorter time to death from relapse (<i>P</i>=0.003). However, when an increase in expression in the transition from hormone-sensitive to -refractory prostate cancer was investigated, an increase in expression of PI3K was associated with decreased time to biochemical relapse (<i>P</i>=0.014), and an increase in expression of pAkt<sup>473</sup> and pAR<sup>210</sup> were associated with decreased disease-specific survival (<i>P</i>=0.0019 and 0.0015, respectively). Protein expression of pAkt<sup>473</sup> and pAR<sup>210</sup> also strongly correlated (<i>P</i><0.001, c.c.=0.711) in the hormone-refractory prostate tumours. These results provide evidence using clinical specimens, that upregulation of the PI3K/Akt pathway is associated with phosphorylation of the AR during development of HRPC, suggesting that this pathway could be a potential therapeutic target
A selected ion flow tube study of the ion-molecule reactions of monochloroethene, trichloroethene and tetrachloroethene
Data for the rate coefficients and product cations of the reactions of a large number of atomic and small molecular cations with monochloroethene, trichloroethene and tetrachloroethene in a selected ion flow tube at 298 K are reported. The recombination energy of the ions range from 6.27 eV (HO) through to 21.56 eV (Ne). Collisional rate coefficients are calculated by modified average dipole orientation theory and compared with experimental values. Thermochemistry and mass balance predict the most feasible neutral products. Together with previously reported results for the three isomers of dichloroethene (J. Phys. Chem. A., 2006, 110, 5760), the fragment ion branching ratios have been compared with those from threshold photoelectron photoion coincidence spectroscopy over the photon energy range 9-22 eV to determine the importance or otherwise of long-range charge transfer. For ions with recombination energy in excess of the ionisation energy of the chloroethene, charge transfer is energetically allowed. The similarity of the branching ratios from the two experiments suggest that long-range charge transfer is dominant. For ions with recombination energy less than the ionisation energy, charge transfer is not allowed; chemical reaction can only occur following formation of an ion-molecule complex, where steric effects are more significant. The products that are now formed and their percentage yield is a complex interplay between the number and position of the chlorine atoms with respect to the C=C bond, where inductive and conjugation effects can be important
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The Prevalence and Clinical Implications of Comorbid Back Pain in Shoulder Instability: A Multicenter Orthopaedic Outcomes Network (MOON) Shoulder Instability Cohort Study.
Background:Understanding predictors of pain is critical, as recent literature shows that comorbid back pain is an independent risk factor for worse functional and patient-reported outcomes (PROs) as well as increased opioid dependence after total joint arthroplasty. Purpose/Hypothesis:The purpose of this study was to evaluate whether comorbid back pain would be predictive of pain or self-reported instability symptoms at the time of stabilization surgery. We hypothesized that comorbid back pain will correlate with increased pain at the time of surgery as well as with worse scores on shoulder-related PRO measures. Study Design:Cross-sectional study; Level of evidence, 3. Methods:As part of the Multicenter Orthopaedic Outcomes Network (MOON) Shoulder Instability cohort, patients consented to participate in pre- and intraoperative data collection. Demographic characteristics, injury history, preoperative PRO scores, and radiologic and intraoperative findings were recorded for patients undergoing surgical shoulder stabilization. Patients were also asked, whether they had any back pain. Results:The study cohort consisted of 1001 patients (81% male; mean age, 24.1 years). Patients with comorbid back pain (158 patients; 15.8%) were significantly older (28.1 vs 23.4 years; P < .001) and were more likely to be female (25.3% vs 17.4%; P = .02) but did not differ in terms of either preoperative imaging or intraoperative findings. Patients with self-reported back pain had significantly worse preoperative pain and shoulder-related PRO scores (American Shoulder and Elbow Surgeons score, Western Ontario Shoulder Instability Index) (P < .001), more frequent depression (22.2% vs 8.3%; P < .001), poorer mental health status (worse scores for the RAND 36-Item Health Survey Mental Component Score, Iowa Quick Screen, and Personality Assessment Screener) (P < .01), and worse preoperative expectations (P < .01). Conclusion:Despite having similar physical findings, patients with comorbid back pain had more severe preoperative pain and self-reported symptoms of instability as well as more frequent depression and lower mental health scores. The combination of disproportionate shoulder pain, comorbid back pain and mental health conditions, and inferior preoperative expectations may affect not only the patient's preoperative state but also postoperative pain control and/or postoperative outcomes
Effective Soft-Core Potentials and Mesoscopic Simulations of Binary Polymer Mixtures
Mesoscopic molecular dynamics simulations are used to determine the large
scale structure of several binary polymer mixtures of various chemical
architecture, concentration, and thermodynamic conditions. By implementing an
analytical formalism, which is based on the solution to the Ornstein-Zernike
equation, each polymer chain is mapped onto the level of a single soft colloid.
From the appropriate closure relation, the effective, soft-core potential
between coarse-grained units is obtained and used as input to our mesoscale
simulations. The potential derived in this manner is analytical and explicitly
parameter dependent, making it general and transferable to numerous systems of
interest. From computer simulations performed under various thermodynamic
conditions the structure of the polymer mixture, through pair correlation
functions, is determined over the entire miscible region of the phase diagram.
In the athermal regime mesoscale simulations exhibit quantitative agreement
with united atom simulations. Furthermore, they also provide information at
larger scales than can be attained by united atom simulations and in the
thermal regime approaching the phase transition.Comment: 19 pages, 11 figures, 3 table
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