Interacting epidemics and coinfection on contact networks

The spread of certain diseases can be promoted, in some cases substantially, by prior infection with another disease. One example is that of HIV, whose immunosuppressant effects significantly increase the chances of infection with other pathogens. Such coinfection processes, when combined with nontrivial structure in the contact networks over which diseases spread, can lead to complex patterns of epidemiological behavior. Here we consider a mathematical model of two diseases spreading through a single population, where infection with one disease is dependent on prior infection with the other. We solve exactly for the sizes of the outbreaks of both diseases in the limit of large population size, along with the complete phase diagram of the system. Among other things, we use our model to demonstrate how diseases can be controlled not only by reducing the rate of their spread, but also by reducing the spread of other infections upon which they depend.Comment: 9 pages, 3 figure

Lp-solutions of the Navier-Stokes equation with fractional Brownian noise

We study the Navier-Stokes equations on a smooth bounded domain D ⊂ Rd (d = 2 or 3), under the effect of an additive fractional Brownian noise. We show local existence and uniqueness of a mild Lp-solution for p > d.34539553FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP2017/17670-0; 2015/07278-

Maxillary nerve block: A comparison between the greater palatine canal and high tuberosity approaches.

Aim: Analgesia and anxiolysis during dental procedures are important for dental care and patient compliance. This study aims to compare two classical maxillary nerve block (MNB) techniques: the greater palatine canal (GPC) and the high tuberosity (HT) approaches, seldom used in routine dental practice. Methods: The study was conducted on 30 patients, scheduled for sinus lift surgery, who were randomly divided into 2 groups: the GPC approach to the MNB was used in 15 and the HT one in the other 15 patients. Anxiolysis was also used, depending on the results of the pre- preoperative assessment. Patients\u2019 sensations/pain during the procedure, details about anesthesia, and the dentist\u2019s considerations were all recorded. Data are expressed as mean \ub1SD. Statistical tests including ANOVA, \u3c72 following Yates correction and linear regression analysis were carried out. A < 0.05 p value was considered significant. Results: Study results showed that the anesthesia was effective and constant in the molar and premolar area. Additional infiltrations of local anesthetics were necessary for vestibular and palatal areas in the anterior oral cavity, respectively, in the GPC and HT groups. The two techniques were equally difficult to carry out in the dentist\u2019s opinion. There were no differences in pain or unpleasant sensations between the two groups, nor were any anesthesia-related complications reported. Conclusion: The GPC approach ensures effective anesthesia in the posterior maxillary region as far as both the dental pulp and the palatal/vestibular mucous membranes are concerned; the HT approach did not guarantee adequate anesthesia of the pterygopalatine branch of the maxillary nerve. These regional anesthesia techniques were characterized by a low incidence of intra and postoperative pain, no noteworthy complications, and high patient satisfaction

Religious tourism and seduction: the case of Sacred Mount of Varallo

Since 2003 the Sacred Mount of Varallo is included in the World Heritage List of UNESCO because it represents a successful integration of architecture and fine art into a landscape of great beauty for spiritual reasons. As the other Sacred Mounts of Piemonte and Lombardia (Italy), it represents a place in witch all visitors (tourist or pilgrims) couldn\u2019t resist the attraction of and environment full of spiritual and natural seduction. According to these characteristics, the paper aims to define who visits the Sacred Mount of Varallo and which experiences he/she is looking for. In this way we try to understand how a classical religious tourism destination could seduce the third millennium tourist. The research methodology is based both on official statistical data, and on a questionnaire delivered to visitors

Bariatric surgery in an obese patient with Albright hereditary osteodystrophy: a case report

INTRODUCTION: We report for the first time the case of a patient with Albright hereditary osteodystrophy and pseudopseudohypoparathyroidism who underwent a Roux-en-Y gastric bypass. CASE PRESENTATION: A 26-year-old obese Caucasian woman with Albright hereditary osteodystrophy with pseudopseudohypoparathyroidism (heterozygous mutation (L272F) in GNAS1 exon 10 on molecular analysis) was treated with gastric bypass. She had the classical features of Albright hereditary osteodystrophy: short stature (138cm), obesity (body mass index 49.5kg/m2), bilateral shortening of the fourth and fifth metacarpals, short neck, round and wide face with bombed front and small eyes. Before the gastric bypass was performed, biochemical determination revealed a slightly low serum calcium level (2.09mmol/L; normal range 2.1 to 2.5mmol/l), and an elevated parathyroid hormone level (87ng/L; normal range 10 to 70ng/L) associated with low vitamin D level (19μg/L; normal range 30 to 50μg/L). Vitamin D supplementation was prescribed before surgery. After the Roux-en-Y gastric bypass, she achieved a progressive substantial weight loss, from 94kg (body mass index 49.5kg/m2) to 49kg (body mass index 25.9kg/m2) in one year. Her weight then stabilized at 50kg (body mass index 26kg/m2) during our three years of follow-up. Before the operation and every three months after it, she was screened for nutritional deficiencies, and serum markers of bone turnover and renal function were monitored. Considering the deficiencies in zinc, magnesium, calcium, vitamin D and vitamin B12, appropriate supplementation was prescribed. Before and two years after the Roux-en-Y gastric bypass, a dual-energy X-ray absorptiometry assessment of bone density was performed that showed no changes on her lumbar column (0.882g/cm2 and both T-score and Z-score of -1.5 standard deviation). In addition, bone microarchitecture with a measurement of her trabecular bone score was found to be normal. CONCLUSION: This is the first case of Roux-en-Y gastric bypass described in a patient with pseudopseudohypoparathyroidism showing that such a procedure seems to be safe in obese patients with Albright hereditary osteodystrophy and pseudopseudohypoparathyroidism if appropriately followed up. As obesity is a prominent feature of Albright hereditary osteodystrophy, such patients might seek bariatric surgery. After a Roux-en-Y gastric bypass, patients with Albright hereditary osteodystrophy associated with pseudopseudohypoparathyroidism need long-term follow-up on nutritional and metabolic issues

Control strategies for integration of electric motor assist and functional electrical stimulation in paraplegic cycling: Utility for exercise testing and mobile cycling

AIM: The aim of this study was to investigate feedback control strategies for integration of electric motor assist and functional electrical stimulation (FES) for paraplegic cycling, with particular focus on development of a testbed for exercise testing in FES cycling, in which both cycling cadence and workrate are simultaneously well controlled and contemporary physiological measures of exercise performance derived. A second aim was to investigate the possible benefits of the approach for mobile, recreational cycling. METHODS: A recumbent tricycle with an auxiliary electric motor is used, which is adapted for paraplegic users, and instrumented for stimulation control. We propose a novel integrated control strategy which simultaneously provides feedback control of leg power output (via automatic adjustment of stimulation intensity) and cycling cadence (via electric motor control). Both loops are designed using system identification and analytical (model-based) feedback design methods. Ventilatory and pulmonary gas exchange response profiles are derived using a portable system for real-time breath-by-breath acquisition. RESULTS:We provide indicative results from one paraplegic subject in which a series of feedback-control tests illustrate accurate control of cycling cadence, leg power control, and external disturbance rejection. We also provide physiological response profiles from a submaximal exercise step test and a maximal incremental exercise test, as facilitated by the control strategy. CONCLUSION: The integrated control strategy is effective in facilitating exercise testing under conditions of well-controlled cadence and power output. Our control approach significantly extends the achievable workrate range and enhances exercise-test sensitivity for FES cycling, thus allowing a more stringent characterization of physiological response profiles and estimation of key parameters of aerobic function.We further conclude that the control approach can significantly improve the overall performance of mobile recreational cycling

GCRT J1745-3009 as a Transient White Dwarf Pulsar

A transient radio source in the direction of the Galactic Center, GCRT J1745-3009, exhibited 5 peculiar consecutive outbursts at 0.33 GHz with a period of 77.13 minutes and a duration of ~10 minutes for each outburst. It has been claimed to be the prototype of a hitherto unknown class of transient radio sources. We interpret it as a transient white dwarf pulsar with a period of 77.13 minutes. The ~10-minute flaring duration corresponds to the epoch when the radio beam sweeps our line of sight. The bursting epoch corresponds to the episodes when stronger sunspot-like magnetic fields emerge into the white dwarf polar cap region during which the pair production condition is satisfied and the white dwarf behaves like a radio pulsar. It switches off as the pair production condition breaks down.Comment: minor changes, ApJL, in pres