A complete characterization of phase space measurements

We characterize all the phase space measurements for a non-relativistic particle.Comment: 11 pages, latex, no figures, iopart styl

On the spectrum of Farey and Gauss maps

In this paper we introduce Hilbert spaces of holomorphic functions given by generalized Borel and Laplace transforms which are left invariant by the transfer operators of the Farey map and its induced version, the Gauss map, respectively. By means of a suitable operator-valued power series we are able to study simultaneously the spectrum of both these operators along with the analytic properties of the associated dynamical zeta functions.Comment: 23 page

The Link Between Insecure Attachment and Depression: Two Potential Pathways

A wealth of research demonstrates a strong link between insecure attachment and depressive symptoms. However, thus far no work has discerned different pathways to depression for each of the insecure subtypes: anxious and avoidant attachment. This work looks at the behaviors that couples engage in during a conflict interaction as a potential mediator for the attachment-depression relationship, with different behaviors mediating the link between anxious and avoidant attachment and depression. For anxiously attached individuals, it was predicted that lack of support and response from the partner (actual or perceived) would account for the relationship between their attachment and depressive symptoms. While for avoidant individuals, it was predicted that partners’ hostile behaviors would account for a positive association between attachment and depression, but humor and relationship-enhancing behaviors would account for a negative association between attachment and depression. Results from this work indicated that for anxiously attached women, their perceptions of their partners’ responsiveness and their partners’ actual hostility mediated the link between their attachment and depressive symptoms

Downregulation of DAX-1 Expression via miRNA Overexpression as a Mechanism to Potentiate Breast Cancer

The orphan nuclear receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, critical region on the X chromosome, gene 1) plays a key role in mammalian sex determination and steroidogenesis. In addition to these canonical examples, DAX-1 has been shown to play a contradictory role in cancer development. While DAX-1 is overexpressed in lung and prostate cancer, it is downregulated in breast cancer. One of the explanations for the paradoxical role of DAX-1 in cancer development could be microRNA (miRNA) dysregulation. After broadly surveying over 96 miRNAs historically upregulated in MCF7 breast cancer cells, we compared the expression of DAX-1 in MCF7 and MCF10A (normal breast epithelial) cells with the presence of specific miRNA inhibitors. Our primary hypothesis remains that multiple miRNAs negatively regulate the expression of DAX-1 in human breast cancer cells and are not overexpressed in normal breast cells, providing another mechanism of lifting the repression of DAX-1 expression. Quantitative PCR and western blot analysis was performed indicating that miRNA-29b, 100, 199a, and 424 all downregulate DAX-1 expression. Similar techniques were explored to determine that miR-20b and miR-22 inhibition downregulates Estrogen Receptor α expression whereas miR-29b, 29c, and 424 inhibition indicates Cyclin D1 underexpression. Finally, we examined the migratory properties of MCF7 cells following miRNA inhibition via scratch-and-heal assays. This research will allow clinicians to screen for miRNAs that are elevated in BC patients substantially increasing the number of people diagnosed with breast cancer early on, and it will provide another method for diagnosing breast cancer or those who do not have access to preventative care

Parents\u27 Value of Play in Early Childhood: A Comparative Study of Spousal Play Beliefs

Play is a vital tool for developmental growth and learning in early childhood. However, with the current focus on academics, there is less emphasis placed on encouraging children to play. The current study investigated parental beliefs on play. The sample consisted of 34 middle-class couples (34 mothers, 34 fathers) co-parenting a preschool-aged child (3-5 years) attending the laboratory school of a large mid-Atlantic university. Participants were surveyed about their beliefs on play. Results revealed mothers\u27 value of play to be higher than fathers\u27. Although significantly different, both mothers and fathers perceived play positively. The findings suggest that early childhood professionals need to further advocate the importance of quality play and its ties with academic achievement to all parents, especially those from lower socioeconomic backgrounds.;Keywords: play, belief, parent, academics, early childhood

Correspondence Between Change in Adult Attachment Patterns and Change in Depression Symptoms in Early Marriage

Countless studies have demonstrated the association between attachment styles and depressive symptoms; however, thus far, none have examined concurrent change. That is, does change in attachment style predict change in depressive symptoms over time? This question was examined in a sample of 229 heterosexual newlywed couples from Western Massachusetts. It was found that changes in attachment avoidance in particular predicted changes in depressive and anxious symptoms over time. Being a parent also played a role in participants\u27 overall attachment styles, depressive symptoms and anxious symptoms on average, with differences observed by gender. Implications and suggestions for future research are discussed

Dysfunctional Attitudes and Low Self-Esteem Mediate the Effect of Attachment Anxiety Priming on Depression

Previous studies regarding the relationship between attachment anxiety and depression and the mediating roles of dysfunctional attitudes and self-esteem have been correlational in nature. The current study used an experimental design to look at these relationships. Attachment style was determined using a shortened version of the Experiences in Close Relationships Scale, and then either secure attachment, anxious attachment, or a control of grocery shopping was primed by instructing participants to write about one of the three scenarios. Dysfunctional attitudes were assessed, followed by state self-esteem and then state depression. Multiple regression analyses revealed that trait attachment anxiety and the anxiety prime predict dysfunctional attitudes, which in turn predict state-self esteem. Finally, state-self esteem predicted state depression and rendered previously significant associations between attachment anxiety, avoidance, anxiety priming, dysfunctional attitudes and depression insignificant when included in the analysis

Decreased olfactory discrimination is associated with impulsivity in healthy volunteers

In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex. In healthy individuals, the relationship between olfaction and personality traits or certain cognitive and behavioural characteristics remains unexplored. We therefore tested if olfactory function is associated with trait and behavioural impulsivity in nonclinical individuals. Eighty-three healthy volunteers (50 females) underwent quantitative assessment of olfactory function (odour detection threshold, discrimination, and identifcation). Each participant was rated for trait impulsivity index using the Barratt Impulsiveness Scale and performed a battery of tasks to assess behavioural impulsivity (Stop Signal Task, SST; Information Sampling Task, IST; Delay Discounting). Lower odour discrimination predicted high ratings in non-planning impulsivity (Barratt Non-Planning impulsivity subscale); both, lower odour discrimination and detection threshold predicted low inhibitory control (SST; increased motor impulsivity). These fndings extend clinical observations to support the hypothesis that defcits in olfactory ability are linked to impulsive tendencies within the healthy population. In particular, the relationship between olfactory abilities and behavioural inhibitory control (in the SST) reinforces evidence for functional overlap between neural networks involved in both processes. These fndings may usefully inform the stratifcation of people at risk of impulse-control-related problems and support planning early clinical interventions

Multi-year climate memory in shallow lake water levels

Landscape hydrologic memory of meteorological cycles can have an important impact on catchment hydrological responses by propagating clustering of wet or dry conditions into extreme events. The non-linear and hysteretic hydrologic response functions driven by memory are often only studied at shorter temporal scales (event, season) despite larger interannual hydrologic responses evident in some systems. Within the Canadian Boreal, lakes and lake water levels provide an important indicator that can be used to assess the role of landscape memory on catchment hydrological function. Landscape memory has also been hypothesised to control the hydrological dynamics of shallow lake ecosystems that are also important biogeochemically and ecologically. Here we combine measurements of lake water levels in 26 lakes of varying type at varying temporal frequencies within the glaciated sub-humid Boreal Plain, to examine the impact and variability of interdecadal, decadal, multi-year, and intra-annual memory on lake water levels. We show multi-annual hysteresis of precipitation-lake water levels with varied characteristics in space and time. These spatial variations in landscape memory are driven by differences in storage capacities controlled by heterogeneity in glacial landforms, wetland-forest landcover and lake properties. Thus, the propensity for drought years or wet years to persist or accumulate into extreme landscape drying or wetting varies significantly between different lake-landscape characteristics. We show how landscape memory is crucial to project lake water levels by defining spatial variability of the impact of periods of meteorological drought and deluge vital for understanding system sensitivity, duration of recovery and in turn infer resilience on Boreal Plain hydrology.<br/

Translating Glutamate: From Pathophysiology to Treatment

The neurotransmitter glutamate is the primary excitatory neurotransmitter in mammalian brain and is responsible for most corticocortical and corticofugal neurotransmission. Disturbances in glutamatergic function have been implicated in the pathophysiology of several neuropsychiatric disorders—including schizophrenia, drug abuse and addiction, autism, and depression—that were until recently poorly understood. Nevertheless, improvements in basic information regarding these disorders have yet to translate into Food and Drug Administration–approved treatments. Barriers to translation include the need not only for improved compounds but also for improved biomarkers sensitive to both structural and functional target engagement and for improved translational models. Overcoming these barriers will require unique collaborative arrangements between pharma, government, and academia. Here, we review a recent Institute of Medicine–sponsored meeting, highlighting advances in glutamatergic theories of neuropsychiatric illness as well as remaining barriers to treatment development.National Institute of Mental Health (U.S.) (grant R37MH49334)National Institute of Mental Health (U.S.) (Intramural Research Program)National Institute of Mental Health (U.S.) (R01DA03383)National Institute of Mental Health (U.S.) (P50MH086385)National Institutes of Health (U.S.)FRAXA Research FoundationHoward Hughes Medical InstituteSimons Foundatio