Protocol for a longitudinal qualitative interview study: maintaining psychological well-being in advanced cancer - what can we learn from patients' and carers' own coping strategies?

IntroductionPeople with advanced cancer and their carers experience stress and uncertainty which affects the quality of life and physical and mental health. This study aims to understand how patients and carers recover or maintain psychological well-being by exploring the strategies employed to self-manage stress and uncertainty.Methods and analysisA longitudinal qualitative interview approach with 30 patients with advanced cancer and 30 associated family or informal carers allows the exploration of contexts, mechanisms and outcomes at an individual level. Two interviews, 4–12?weeks apart, will not only enable the exploration of individuals’ evolving coping strategies in response to changing contexts but also how patients’ and carers’ strategies inter-relate. Patient and Carer focus groups will then consider how the findings may be used in developing an intervention. Recruiting through two major tertiary cancer centres in the North West and using deliberately broad and inclusive criteria will enable the sample to capture demographic and experiential breadth.Ethics and disseminationThe research team will draw on their considerable experience to ensure that the study is sensitive to a patient and carer group, which may be considered vulnerable but still values being able to contribute its views. Public and patient involvement (PPI) is integral to the design and is evidenced by: a research advisory group incorporating patient and carers, prestudy consultations with the PPI group at one of the study sites and a user as the named applicant. The study team will use multiple methods to disseminate the findings to clinical, policy and academic audiences. A key element will be engaging health professionals in patient and carer ideas for promoting self-management of psychological well-being. The study has ethical approval from the North West Research Ethics Committee and the appropriate NHS governance clearance.RegistrationNational Institute for Health Research (NIHR) Clinical Studies Portfolio, UK Clinical Research Network (UKCRN) Study number 11725

Perturbations in the relaxation mechanism for a large cosmological constant

Recently, a mechanism for relaxing a large cosmological constant (CC) has been proposed [arxiv:0902.2215], which permits solutions with low Hubble rates at late times without fine-tuning. The setup is implemented in the LXCDM framework, and we found a reasonable cosmological background evolution similar to the LCDM model with a fine-tuned CC. In this work we analyse analytically the perturbations in this relaxation model, and we show that their evolution is also similar to the LCDM model, especially in the matter era. Some tracking properties of the vacuum energy are discussed, too.Comment: 18 pages, LaTeX; discussion improved, accepted by CQ

Design definition study of a NASA/Navy lift/cruise fan technology V/STOL airplane: Risk assessment addendum to the final report

An assessment of risk, in terms of delivery delays, cost overrun, and performance achievement, associated with the V/STOL technology airplane is presented. The risk is discussed in terms of weight, structure, aerodynamics, propulsion, mechanical drive, and flight controls. The analysis ensures that risks associated with the design and development of the airplane will be eliminated in the course of the program and a useful technology airplane that meets the predicted cost, schedule, and performance can be produced

Could Black Be the New Gold? Design-Driven Challenges in New Sustainable Luxury Materials for Jewelry

Is there a new material for use in jewelry, matching gold and precious stones, capable of maintaining the same perception of “preciousness” but that is also more sustainable, ethical, and inexpensive? This article deals with a case study within the European EcoDesign Network research project, aimed at investigating how sustainable design can help prestigious companies pinpoint new materials for the creation of jewelry, focusing on new and environmentally friendly opportunities while preserving their market position and target audience. Qualitative and quantitative analyses were performed. Adopting the exploring design path, a jewelry background analysis pointed out both stereotypes and possible innovations in the jewelry field: an analysis was carried out on the perception of jewels by a panel guided by a cognitive ergonomics specialist, also using the eye-tracking machine to examine participants’ reactions to the jewelry involved in the study, and to establish paradigms of sustainability, preciousness, and innovation. Several meta-project proposals regarding innovations in materials and finishing were hypothesized and tested, following the main guidelines and principles of ecodesign. Lastly, a prototyping phase and some mechanical tests were implemented to verify the hypotheses of innovation. The results allowed the creation of a first set of sustainable jewelry, currently on the market

Kronos: a workflow assembler for genome analytics and informatics.

BackgroundThe field of next-generation sequencing informatics has matured to a point where algorithmic advances in sequence alignment and individual feature detection methods have stabilized. Practical and robust implementation of complex analytical workflows (where such tools are structured into "best practices" for automated analysis of next-generation sequencing datasets) still requires significant programming investment and expertise.ResultsWe present Kronos, a software platform for facilitating the development and execution of modular, auditable, and distributable bioinformatics workflows. Kronos obviates the need for explicit coding of workflows by compiling a text configuration file into executable Python applications. Making analysis modules would still require programming. The framework of each workflow includes a run manager to execute the encoded workflows locally (or on a cluster or cloud), parallelize tasks, and log all runtime events. The resulting workflows are highly modular and configurable by construction, facilitating flexible and extensible meta-applications that can be modified easily through configuration file editing. The workflows are fully encoded for ease of distribution and can be instantiated on external systems, a step toward reproducible research and comparative analyses. We introduce a framework for building Kronos components that function as shareable, modular nodes in Kronos workflows.ConclusionsThe Kronos platform provides a standard framework for developers to implement custom tools, reuse existing tools, and contribute to the community at large. Kronos is shipped with both Docker and Amazon Web Services Machine Images. It is free, open source, and available through the Python Package Index and at https://github.com/jtaghiyar/kronos

Ileal neuroendocrine tumor in a patient with sclerosing mesenteritis: Which came first?

Objective: Unusual clinical courseBackground: Jejunoileal neuroendocrine tumors (JI-NETs) are rare tumors that can be associated with mesenteric fibrosis. This case report is of an incidental finding of a JI-NET in a patient who was previously misdiagnosed with sclerosing mesenteritis.Case Report: A 42-year-old man was admitted to our institution with diffuse abdominal pain and clinical and radiographic signs of bowel obstruction. He had a previous diagnosis of sclerosing mesenteritis, which had been histologically diagnosed after an exploratory laparoscopy performed in 2009 for recurrent acute abdominal pain. He was also annually monitored through computed tomography scans for an incidentally discovered, gradually enlarging mesenteric mass for which a "wait and watch" management approach was adopted. After a period of fasting and observation, the patient underwent an urgent exploratory laparotomy because of his worsening condition. Intraoperatively, an ileocecal resection was performed, along with excision of the known mesenteric mass. The pathology report revealed an ileal NET with nodal metastases within the mesentery and mesenteric tumor deposits (pT3N1).Conclusions: JI-NETs are rare entities, which are usually encountered as incidental findings or in patients with unspecific abdominal pain. Our case represents a probable delayed diagnosis of JI-NET in the context of sclerosing mesenteritis; therefore, a possible association between these 2 conditions should be investigated

Open-source Simulation of Underwater Gliders

Autonomous underwater gliders (AUGs) are currently deployed in oceans throughout the globe and are recording real-time, in-situ data. Simulating AUGs is rendered particularly difficult by the identification of the underlying dynamic model, as these vehicles embed several internal movable components. Acausal simulators can significantly improve the possibility to study and understand the dynamics of this class of vehicles and can in turn support the design of more robust control systems. In this paper, an open-source simulator architecture designed in OpenModelica is proposed to simulate underwater gliders. The validation is carried out using two different AUGs models, a ROGUE and a Seawing. The vehicle dynamics is firstly compared with analytical results and, following, with values obtained by means of another simulator. Further steps will entail comparing the dynamics of a simulated Seaglider with real deployment data publicly available. In this work, some of the main hydrodynamic and geometrical properties of a Seaglider are identified, computed through Computational Fluid Dynamics (CFD) analyses and retrieved from the mission ballast sheet. Overall, the developed model is expected to enhance gliders’ control strategies, thus improving their performance and mitigating incidents such as being carried away by undesired ocean currents

Lunar elemental composition and ivestigations with D-CIXS x-ray mapping spectrometer on SMART-1

The D-CIXS Compact X-ray Spectrometer on ESA SMART-1 successfully launched in Sept 2003 can derive 45 km resolution images of the Moon with a spectral resolution of 185 eV, providing the first high-resolution global map of rock forming element abundances

Shedding New Light on Kaon-Nucleon/Nuclei Interaction and Its Astrophysical Implications with the AMADEUS Experiment at DAFNE

The AMADEUS experiment deals with the investigation of the low-energy kaon-nuclei hadronic interaction at the DA{\Phi}NE collider at LNF-INFN, which is fundamental to respond longstanding questions in the non-perturbative QCD strangeness sector. The antikaon-nucleon potential is investigated searching for signals from possible bound kaonic clusters, which would open the possibility for the formation of cold dense baryonic matter. The confirmation of this scenario may imply a fundamental role of strangeness in astrophysics. AMADEUS step 0 consisted in the reanalysis of 2004/2005 KLOE dataset, exploiting K- absorptions in H, 4He, 9Be and 12C in the setup materials. In this paper, together with a review on the multi-nucleon K- absorption and the particle identification procedure, the first results on the {\Sigma}0-p channel will be presented including a statistical analysis on the possible accomodation of a deeply bound stateComment: 6 pages, 2 figure, 1 table, HADRON 2015 conferenc

Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro.

Monocytes/macrophages are key players in all phases of physiological and pathological inflammation. To understanding the regulation of macrophage functional differentiation during inflammation, we designed an in vitro model that recapitulates the different phases of the reaction (recruitment, initiation, development, and resolution), based on human primary blood monocytes exposed to sequential changes in microenvironmental conditions. All reaction phases were profiled by transcriptomic microarray analysis. Distinct clusters of genes were identified that are differentially regulated through the different phases of inflammation. The gene sets defined by GSEA analysis revealed that the inflammatory phase was enriched in inflammatory pathways, while the resolution phase comprised pathways related to metabolism and gene rearrangement. By comparing gene clusters differentially expressed in monocytes vs. M1 and vs. M2 macrophages extracted from an in-house created meta-database, it was shown that cells in the model resemble M1 during the inflammatory phase and M2 during resolution. The validation of inflammatory and transcriptional factors by qPCR and ELISA confirmed the transcriptomic profiles in the different phases of inflammation. The accurate description of the development of the human inflammatory reaction provided by this in vitro kinetic model can help in identifying regulatory mechanisms in physiological conditions and during pathological derangement