Horseshoe patterns: visualizing partisan media trust in Germany

A trusted media is crucial for a politically informed citizenry, yet media trust has become fragile in many Western countries. An underexplored aspect is the link between media (dis)trust and populism. The authors visualize media trust across news outlets and partisanship in Germany, for both mainstream and “alternative” news sources. For each source, average trust is grouped by partisanship and sorted from left to right, allowing within-source comparisons. The authors find an intriguing horseshoe pattern for mainstream media sources, for which voters of both populist left-wing and right-wing parties express lower levels of trust. The underlying distribution of individual responses reveals that voters of the right-wing populist party are especially likely to “not at all” trust the mainstream outlets that otherwise enjoy high levels of trust. The media trust gap between populist and centrist voters disappears for alternative sources, for which trust is generally low

IEEE Software Defined Network Initiative

This paper outlines a proposal for setting up an IEEE initiative on software defined networks (SDNs) to facilitate professional and academic exchange of SDN-related ideas, research, and development. The proposal is a result of an intensive effort of a team consisting of the authors. After a comprehensive gap analysis, gaps and key opportunities were identified. Finally, a specific set of components along with schedule and financial consideration were proposed in the areas of publications, conferences, standards, education, certification, and publicity

White Matter Changes in Patients with Friedreich Ataxia after Treatment with Erythropoietin

Background and Purpose—Erythropoietin (EPO) has received growing attention because of its neuro-regenerative properties. Preclinical and clinical evidence supports its therapeutic potential in brain conditions like stroke, multiple sclerosis and schizophrenia. Also in Friedreich ataxia, clinical improvement after EPO therapy was shown. The aim of the present study was to assess possible therapy-associated brain white-matter changes in these patients.Methods—Nine patients with Friedreich ataxia underwent Diffusion Tensor Imaging (DTI) before and after EPO treatment. Tract-based spatial statistics (TBSS) was used for longitudinal comparison. Results—We detected widespread longitudinal increase in fractional anisotropy (FA) and axial diffusivity (D||) in cerebral hemispheres bilaterally (p<0.05, corrected), while no changes were observed within the cerebellum, medulla oblongata and pons. Conclusions—To the best of our knowledge, this is the first DTI study to investigate the effects of erythropoietin in a neurodegenerative disease. Anatomically, the diffusivity changes appear disease-unspecific, and their biological underpinnings deserve further study

Enveloping Sophisticated Tools into Process-Centered Environments

We present a tool integration strategy based on enveloping pre-existing tools without source code modifications or recompilation, and without assuming an extension language, application programming interface, or any other special capabilities on the part of the tool. This Black Box enveloping (or wrapping) idea has existed for a long time, but was previously restricted to relatively simple tools. We describe the design and implementation of, and experimentation with, a new Black Box enveloping facility intended for sophisticated tools --- with particular concern for the emerging class of groupware applications

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can take advantage of relatedness between sequenced and non-sequenced samples to improve accuracy. We use this method to create a new 1000GP haplotype reference set for use by the human genetic community. Using a set of validation genotypes at SNP and bi-allelic indels we show that these haplotypes have lower genotype discordance and improved imputation performance into downstream GWAS samples, especially at low-frequency variants. © 2014 Macmillan Publishers Limited. All rights reserved